7UO4

SARS-CoV-2 replication-transcription complex bound to Remdesivir triphosphate, in a pre-catalytic state

Summary for 7UO4

Entry DOI	10.2210/pdb7uo4/pdb
EMDB information	26639
Descriptor	RNA-directed RNA polymerase, Non-structural protein 8, Non-structural protein 7, ... (9 entities in total)
Functional Keywords	rna-directed 5'-3' rna polymerase activity, positive stranded viral rna replication, replication
Biological source	Severe acute respiratory syndrome coronavirus 2 More
Total number of polymer chains	6
Total formula weight	190322.54
Authors	Malone, B.F.,Perry, J.K.,Appleby, T.C.,Feng, J.Y.,Campbell, E.A.,Darst, S.A. (deposition date: 2022-04-12, release date: 2022-11-30, Last modification date: 2023-03-08)
Primary citation	Malone, B.F.,Perry, J.K.,Olinares, P.D.B.,Lee, H.W.,Chen, J.,Appleby, T.C.,Feng, J.Y.,Bilello, J.P.,Ng, H.,Sotiris, J.,Ebrahim, M.,Chua, E.Y.D.,Mendez, J.H.,Eng, E.T.,Landick, R.,Gotte, M.,Chait, B.T.,Campbell, E.A.,Darst, S.A. Structural basis for substrate selection by the SARS-CoV-2 replicase. Nature, 614:781-787, 2023 Cited by PubMed: 36725929 DOI: 10.1038/s41586-022-05664-3 PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (3.38 Å)

Structure validation