8SQK

SARS-CoV-2 replication-transcription complex bound to RNA-nsp9 and GDP-betaS, as a pre-catalytic deRNAylation/mRNA capping intermediate

Summary for 8SQK

• Entry DOI: 10.2210/pdb8sqk/pdb
• Related: 8SQ9 8SQJ
• EMDB information: 40699 40707 40708
• Descriptor: RNA-directed RNA polymerase nsp12, MAGNESIUM ION, Non-structural protein 8, ... (11 entities in total)
• Functional Keywords: rtc, nsp12, nsp9, niran, sars-cov-2, dernaylation, mrna capping, umpcpp, viral protein
• Biological source: Severe acute respiratory syndrome coronavirus 2; More
• Total number of polymer chains: 8
• Total formula weight: 200705.81

Authors

Small, G.I.,Darst, S.A.,Campbell, E.A. (deposition date: 2023-05-04, release date: 2023-11-22)

• Primary citation: Small, G.I.,Fedorova, O.,Olinares, P.D.B.,Chandanani, J.,Banerjee, A.,Choi, Y.J.,Molina, H.,Chait, B.T.,Darst, S.A.,Campbell, E.A.; Structural and functional insights into the enzymatic plasticity of the SARS-CoV-2 NiRAN domain.; Mol.Cell, 83:3921-3930.e7, 2023; PubMed: 37890482; DOI: 10.1016/j.molcel.2023.10.001

Experimental method

ELECTRON MICROSCOPY (3.01 Å)