4O4R

Murine Norovirus RdRp in complex with PPNDS

Summary for 4O4R

Entry DOI	10.2210/pdb4o4r/pdb
Descriptor	RNA-dependent-RNA-polymerase, 3-[(E)-{4-formyl-5-hydroxy-6-methyl-3-[(phosphonooxy)methyl]pyridin-2-yl}diazenyl]-7-nitronaphthalene-1,5-disulfonic acid, SULFATE ION, ... (4 entities in total)
Functional Keywords	rna-dependent-rna-polymerase, rna binding, viral protein-replication inhibitor complex, viral protein/replication inhibitor
Biological source	Murine norovirus 1
Total number of polymer chains	3
Total formula weight	179905.50
Authors	Croci, R.,Tarantino, D.,Milani, M.,Pezzullo, M.,Bolognesi, M.,Mastrangelo, E. (deposition date: 2013-12-19, release date: 2014-11-05, Last modification date: 2023-11-08)
Primary citation	Croci, R.,Tarantino, D.,Milani, M.,Pezzullo, M.,Rohayem, J.,Bolognesi, M.,Mastrangelo, E. PPNDS inhibits murine Norovirus RNA-dependent RNA-polymerase mimicking two RNA stacking bases. Febs Lett., 588:1720-1725, 2014 Cited by PubMed: 24657439 DOI: 10.1016/j.febslet.2014.03.021 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.4 Å)

Structure validation