4O4R
Murine Norovirus RdRp in complex with PPNDS
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003723 | molecular_function | RNA binding |
| A | 0003968 | molecular_function | RNA-directed RNA polymerase activity |
| A | 0004386 | molecular_function | helicase activity |
| A | 0005524 | molecular_function | ATP binding |
| A | 0006351 | biological_process | DNA-templated transcription |
| A | 0039694 | biological_process | viral RNA genome replication |
| B | 0003723 | molecular_function | RNA binding |
| B | 0003968 | molecular_function | RNA-directed RNA polymerase activity |
| B | 0004386 | molecular_function | helicase activity |
| B | 0005524 | molecular_function | ATP binding |
| B | 0006351 | biological_process | DNA-templated transcription |
| B | 0039694 | biological_process | viral RNA genome replication |
| C | 0003723 | molecular_function | RNA binding |
| C | 0003968 | molecular_function | RNA-directed RNA polymerase activity |
| C | 0004386 | molecular_function | helicase activity |
| C | 0005524 | molecular_function | ATP binding |
| C | 0006351 | biological_process | DNA-templated transcription |
| C | 0039694 | biological_process | viral RNA genome replication |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE 20V A 601 |
| Chain | Residue |
| A | MET219 |
| A | HOH718 |
| A | MET221 |
| A | TYR341 |
| A | LEU391 |
| A | ARG392 |
| A | ARG393 |
| A | GLN414 |
| A | LYS419 |
| A | 20V602 |
| site_id | AC2 |
| Number of Residues | 13 |
| Details | BINDING SITE FOR RESIDUE 20V A 602 |
| Chain | Residue |
| A | PHE29 |
| A | LYS166 |
| A | LEU169 |
| A | TYR341 |
| A | ARG392 |
| A | SER410 |
| A | ARG413 |
| A | GLN414 |
| A | LYS419 |
| A | 20V601 |
| A | HOH718 |
| A | HOH724 |
| A | HOH896 |
| site_id | AC3 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE SO4 A 603 |
| Chain | Residue |
| A | GLY48 |
| A | SER49 |
| A | SER58 |
| A | LEU59 |
| A | HOH733 |
| A | HOH745 |
| A | HOH779 |
| site_id | AC4 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE SO4 A 604 |
| Chain | Residue |
| A | MET360 |
| A | ARG363 |
| A | HOH713 |
| site_id | AC5 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE SO4 A 605 |
| Chain | Residue |
| A | THR117 |
| A | LYS127 |
| A | MET192 |
| A | HOH771 |
| A | HOH773 |
| site_id | AC6 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE SO4 A 606 |
| Chain | Residue |
| A | GLN61 |
| A | ARG64 |
| site_id | AC7 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE SO4 A 607 |
| Chain | Residue |
| A | LYS68 |
| A | SO4608 |
| A | HOH937 |
| A | HOH958 |
| A | HOH968 |
| site_id | AC8 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE SO4 A 608 |
| Chain | Residue |
| A | THR8 |
| A | ALA10 |
| A | GLY11 |
| A | LYS68 |
| A | SO4607 |
| A | HOH720 |
| A | HOH958 |
| site_id | AC9 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE 20V B 601 |
| Chain | Residue |
| B | MET219 |
| B | MET221 |
| B | TYR341 |
| B | LEU391 |
| B | ARG392 |
| B | ARG393 |
| B | LEU406 |
| B | GLN414 |
| B | LYS419 |
| B | 20V602 |
| site_id | BC1 |
| Number of Residues | 11 |
| Details | BINDING SITE FOR RESIDUE 20V B 602 |
| Chain | Residue |
| B | MET28 |
| B | PHE29 |
| B | LEU169 |
| B | TYR341 |
| B | ARG392 |
| B | SER410 |
| B | ARG413 |
| B | GLN414 |
| B | LYS419 |
| B | 20V601 |
| B | HOH724 |
| site_id | BC2 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE SO4 B 603 |
| Chain | Residue |
| B | GLY48 |
| B | SER49 |
| B | SER58 |
| B | LEU59 |
| B | HOH762 |
| B | HOH774 |
| B | HOH782 |
| site_id | BC3 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 B 604 |
| Chain | Residue |
| B | THR8 |
| B | ALA10 |
| B | GLY11 |
| B | SO4605 |
| site_id | BC4 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE SO4 B 605 |
| Chain | Residue |
| B | SO4604 |
| B | HOH701 |
| B | HOH936 |
| site_id | BC5 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE SO4 B 606 |
| Chain | Residue |
| B | ASP407 |
| B | ARG408 |
| B | HIS450 |
| site_id | BC6 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE 20V C 601 |
| Chain | Residue |
| C | HOH863 |
| C | MET219 |
| C | MET221 |
| C | TYR341 |
| C | LEU391 |
| C | ARG392 |
| C | ARG393 |
| C | GLN414 |
| C | LYS419 |
| C | 20V602 |
| site_id | BC7 |
| Number of Residues | 13 |
| Details | BINDING SITE FOR RESIDUE 20V C 602 |
| Chain | Residue |
| C | PHE29 |
| C | LYS166 |
| C | LEU169 |
| C | TYR341 |
| C | ARG392 |
| C | SER410 |
| C | ARG413 |
| C | GLN414 |
| C | LYS419 |
| C | 20V601 |
| C | HOH720 |
| C | HOH795 |
| C | HOH893 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 363 |
| Details | Domain: {"description":"RdRp catalytic","evidences":[{"source":"PROSITE-ProRule","id":"PRU00539","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 6 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"21471315","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"22341781","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"24622391","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 3 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"21471315","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 3 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"21471315","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"24622391","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 3 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"22341781","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"24622391","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
