1J7N
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![BU of 1j7n by Molmil](/molmil-images/mine/1j7n) | Anthrax Toxin Lethal factor | Descriptor: | Lethal Factor precursor, SULFATE ION, ZINC ION | Authors: | Pannifer, A.D, Wong, T.Y, Schwarzenbacher, R, Renatus, M, Petosa, C, Collier, R.J, Bienkowska, J, Lacy, D.B, Park, S, Leppla, S.H, Hanna, P, Liddington, R.C. | Deposit date: | 2001-05-17 | Release date: | 2001-11-07 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Crystal structure of the anthrax lethal factor. Nature, 414, 2001
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1JKY
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![BU of 1jky by Molmil](/molmil-images/mine/1jky) | Crystal Structure of the Anthrax Lethal Factor (LF): Wild-type LF Complexed with the N-terminal Sequence of MAPKK2 | Descriptor: | Lethal Factor, mitogen-activated protein kinase kinase 2 | Authors: | Pannifer, A.D, Wong, T.Y, Schwarzenbacher, R, Renatus, M, Petosa, C, Collier, R.J, Bienkowska, J, Lacy, D.B, Park, S, Leppla, S.H, Hanna, P, Liddington, R.C. | Deposit date: | 2001-07-13 | Release date: | 2001-11-07 | Last modified: | 2023-08-16 | Method: | X-RAY DIFFRACTION (3.9 Å) | Cite: | Crystal structure of the anthrax lethal factor. Nature, 414, 2001
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1PWP
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![BU of 1pwp by Molmil](/molmil-images/mine/1pwp) | Crystal Structure of the Anthrax Lethal Factor complexed with Small Molecule Inhibitor NSC 12155 | Descriptor: | Lethal factor, N,N'-BIS(4-AMINO-2-METHYLQUINOLIN-6-YL)UREA, ZINC ION | Authors: | Wong, T.Y, Schwarzenbacher, R, Liddington, R.C. | Deposit date: | 2003-07-02 | Release date: | 2004-01-13 | Last modified: | 2023-08-16 | Method: | X-RAY DIFFRACTION (2.9 Å) | Cite: | Identification of small molecule inhibitors of anthrax lethal factor. Nat.Struct.Mol.Biol., 11, 2004
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1PWQ
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![BU of 1pwq by Molmil](/molmil-images/mine/1pwq) | Crystal structure of Anthrax Lethal Factor complexed with Thioacetyl-Tyr-Pro-Met-Amide, a metal-chelating peptidyl small molecule inhibitor | Descriptor: | Lethal factor, N-(SULFANYLACETYL)TYROSYLPROLYLMETHIONINAMIDE, ZINC ION | Authors: | Wong, T.Y, Schwarzenbacher, R, Liddington, R.C. | Deposit date: | 2003-07-02 | Release date: | 2004-01-13 | Last modified: | 2023-08-16 | Method: | X-RAY DIFFRACTION (3.52 Å) | Cite: | The structural basis for substrate and inhibitor selectivity of the anthrax lethal factor. Nat.Struct.Mol.Biol., 11, 2004
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1PWU
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![BU of 1pwu by Molmil](/molmil-images/mine/1pwu) | Crystal Structure of Anthrax Lethal Factor complexed with (3-(N-hydroxycarboxamido)-2-isobutylpropanoyl-Trp-methylamide), a known small molecule inhibitor of matrix metalloproteases. | Descriptor: | 3-(N-HYDROXYCARBOXAMIDO)-2-ISOBUTYLPROPANOYL-TRP-METHYLAMIDE, Lethal factor, ZINC ION | Authors: | Wong, T.Y, Schwarzenbacher, R, Liddington, R.C. | Deposit date: | 2003-07-02 | Release date: | 2004-02-03 | Last modified: | 2023-08-16 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | The structural basis for substrate and inhibitor selectivity of the anthrax lethal factor. Nat.Struct.Mol.Biol., 11, 2004
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1PWV
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![BU of 1pwv by Molmil](/molmil-images/mine/1pwv) | |
1PWW
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![BU of 1pww by Molmil](/molmil-images/mine/1pww) | |
1YQY
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![BU of 1yqy by Molmil](/molmil-images/mine/1yqy) | Structure of B. Anthrax Lethal factor in complex with a hydroxamate inhibitor | Descriptor: | (2R)-2-{[(4-FLUORO-3-METHYLPHENYL)SULFONYL]AMINO}-N-HYDROXY-2-TETRAHYDRO-2H-PYRAN-4-YLACETAMIDE, Lethal factor, ZINC ION | Authors: | Shoop, W.L, Xiong, Y, Wiltsie, J, Woods, A, Guo, J, Pivnichny, J.V, Felcetto, T, Michael, B.F, Bansal, A. | Deposit date: | 2005-02-02 | Release date: | 2005-05-31 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Anthrax lethal factor inhibition. Proc.Natl.Acad.Sci.Usa, 102, 2005
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1ZXV
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![BU of 1zxv by Molmil](/molmil-images/mine/1zxv) | |
4DV8
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![BU of 4dv8 by Molmil](/molmil-images/mine/4dv8) | |
4PKR
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![BU of 4pkr by Molmil](/molmil-images/mine/4pkr) | Anthrax toxin lethal factor with bound small molecule inhibitor 10 | Descriptor: | CHLORIDE ION, GLYCEROL, Lethal factor, ... | Authors: | Maize, K.M, De la Mora, T, Finzel, B.C. | Deposit date: | 2014-05-15 | Release date: | 2014-11-12 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Anthrax toxin lethal factor domain 3 is highly mobile and responsive to ligand binding. Acta Crystallogr.,Sect.D, 70, 2014
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4PKU
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![BU of 4pku by Molmil](/molmil-images/mine/4pku) | Anthrax toxin lethal factor with bound small molecule inhibitor 15 | Descriptor: | Lethal factor, N~2~-(3-aminobenzyl)-N~2~-[(4-fluoro-3-methylphenyl)sulfonyl]-N-hydroxy-D-alaninamide, ZINC ION | Authors: | Maize, K.M, De la Mora, T, Finzel, B.C. | Deposit date: | 2014-05-15 | Release date: | 2014-11-12 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Anthrax toxin lethal factor domain 3 is highly mobile and responsive to ligand binding. Acta Crystallogr.,Sect.D, 70, 2014
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4PKS
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![BU of 4pks by Molmil](/molmil-images/mine/4pks) | Anthrax toxin lethal factor with bound small molecule inhibitor 11 | Descriptor: | 1,2-ETHANEDIOL, GLYCEROL, Lethal factor, ... | Authors: | Maize, K.M, De la Mora, T, Finzel, B.C. | Deposit date: | 2014-05-15 | Release date: | 2014-11-12 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Anthrax toxin lethal factor domain 3 is highly mobile and responsive to ligand binding. Acta Crystallogr.,Sect.D, 70, 2014
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4PKQ
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![BU of 4pkq by Molmil](/molmil-images/mine/4pkq) | Anthrax toxin lethal factor with bound zinc | Descriptor: | 1,2-ETHANEDIOL, Lethal factor, TRIETHYLENE GLYCOL, ... | Authors: | Maize, K.M, Finzel, B.C. | Deposit date: | 2014-05-15 | Release date: | 2014-11-12 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Anthrax toxin lethal factor domain 3 is highly mobile and responsive to ligand binding. Acta Crystallogr.,Sect.D, 70, 2014
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4PKW
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![BU of 4pkw by Molmil](/molmil-images/mine/4pkw) | Anthrax toxin lethal factor with bound small molecule inhibitor GM6001 | Descriptor: | 1,2-ETHANEDIOL, 3-(N-HYDROXYCARBOXAMIDO)-2-ISOBUTYLPROPANOYL-TRP-METHYLAMIDE, GLYCEROL, ... | Authors: | Maize, K.M, De la Mora, T, Finzel, B.C. | Deposit date: | 2014-05-15 | Release date: | 2014-11-12 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (1.75 Å) | Cite: | Anthrax toxin lethal factor domain 3 is highly mobile and responsive to ligand binding. Acta Crystallogr.,Sect.D, 70, 2014
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4PKV
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![BU of 4pkv by Molmil](/molmil-images/mine/4pkv) | Anthrax toxin lethal factor with bound small molecule inhibitor 16 | Descriptor: | Lethal factor, N~2~-[4-(aminomethyl)benzyl]-N~2~-[(4-fluoro-3-methylphenyl)sulfonyl]-N-hydroxy-D-alaninamide, ZINC ION | Authors: | Maize, K.M, Finzel, B.C. | Deposit date: | 2014-05-15 | Release date: | 2014-11-12 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Anthrax toxin lethal factor domain 3 is highly mobile and responsive to ligand binding. Acta Crystallogr.,Sect.D, 70, 2014
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4PKT
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![BU of 4pkt by Molmil](/molmil-images/mine/4pkt) | Anthrax toxin lethal factor with bound small molecule inhibitor 13 | Descriptor: | Lethal factor, N~2~-[(4-fluoro-3-methylphenyl)sulfonyl]-N-hydroxy-N~2~-(4-nitrobenzyl)-D-alaninamide, ZINC ION | Authors: | Maize, K.M, De la Mora, T, Finzel, B.C. | Deposit date: | 2014-05-15 | Release date: | 2014-11-12 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Anthrax toxin lethal factor domain 3 is highly mobile and responsive to ligand binding. Acta Crystallogr.,Sect.D, 70, 2014
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4WF6
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![BU of 4wf6 by Molmil](/molmil-images/mine/4wf6) | Anthrax toxin lethal factor with bound small molecule inhibitor MK-31 | Descriptor: | 1,2-ETHANEDIOL, Lethal factor, N~2~-[(4-fluoro-3-methylphenyl)sulfonyl]-N-hydroxy-D-alaninamide, ... | Authors: | Maize, K.M, De la Mora-Rey, T, Finzel, B.C. | Deposit date: | 2014-09-12 | Release date: | 2015-09-09 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (2.6521 Å) | Cite: | Probing the S2' Subsite of the Anthrax Toxin Lethal Factor Using Novel N-Alkylated Hydroxamates. J.Med.Chem., 58, 2015
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4XM8
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![BU of 4xm8 by Molmil](/molmil-images/mine/4xm8) | Anthrax toxin lethal factor with ligand-induced binding pocket | Descriptor: | Lethal factor, N-hydroxy-N~2~-{[3-(methoxymethyl)phenyl]sulfonyl}-N~2~-(2-methylpropyl)-D-valinamide, ZINC ION | Authors: | Maize, K.M, Finzel, B.C. | Deposit date: | 2015-01-14 | Release date: | 2015-11-11 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | Ligand-induced expansion of the S1' site in the anthrax toxin lethal factor. Febs Lett., 589, 2015
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4XM6
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![BU of 4xm6 by Molmil](/molmil-images/mine/4xm6) | Anthrax toxin lethal factor with ligand-induced binding pocket | Descriptor: | 1,2-ETHANEDIOL, Lethal factor, N~2~-[(4-fluoro-3-methylphenyl)sulfonyl]-N-hydroxy-N~2~-(2-methylpropyl)-D-valinamide, ... | Authors: | Maize, K.M, De la Mora-Rey, T, Finzel, B.C. | Deposit date: | 2015-01-14 | Release date: | 2015-11-11 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (2.352 Å) | Cite: | Ligand-induced expansion of the S1' site in the anthrax toxin lethal factor. Febs Lett., 589, 2015
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4XM7
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![BU of 4xm7 by Molmil](/molmil-images/mine/4xm7) | Anthrax toxin lethal factor with ligand-induced binding pocket | Descriptor: | 1,2-ETHANEDIOL, Lethal factor, N~2~-[(4-fluoro-3-methoxyphenyl)sulfonyl]-N-hydroxy-N~2~-(2-methylpropyl)-D-valinamide, ... | Authors: | Maize, K.M, Finzel, B.C. | Deposit date: | 2015-01-14 | Release date: | 2015-11-11 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | Ligand-induced expansion of the S1' site in the anthrax toxin lethal factor. Febs Lett., 589, 2015
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5D1U
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![BU of 5d1u by Molmil](/molmil-images/mine/5d1u) | Anthrax toxin lethal factor with hydroxamic acid inhibitor | Descriptor: | Lethal factor, N~2~-(6-aminohexyl)-N~2~-[(4-fluoro-3-methylphenyl)sulfonyl]-N-hydroxy-D-alaninamide, ZINC ION | Authors: | Maize, K.M, Finzel, B.C. | Deposit date: | 2015-08-04 | Release date: | 2015-11-11 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (2.8503 Å) | Cite: | Probing the S2' Subsite of the Anthrax Toxin Lethal Factor Using Novel N-Alkylated Hydroxamates. J.Med.Chem., 58, 2015
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5D1T
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![BU of 5d1t by Molmil](/molmil-images/mine/5d1t) | Anthrax toxin lethal factor with hydroxamic acid inhibitor | Descriptor: | Lethal factor, N~2~-[3-(aminomethyl)benzyl]-N~2~-[(4-fluoro-3-methylphenyl)sulfonyl]-N-hydroxy-D-alaninamide, ZINC ION | Authors: | Maize, K.M, Finzel, B.C. | Deposit date: | 2015-08-04 | Release date: | 2015-11-11 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Probing the S2' Subsite of the Anthrax Toxin Lethal Factor Using Novel N-Alkylated Hydroxamates. J.Med.Chem., 58, 2015
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5D1S
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![BU of 5d1s by Molmil](/molmil-images/mine/5d1s) | Anthrax toxin lethal factor with hydroxamic acid inhibitor | Descriptor: | Lethal factor, N~2~-[(4-fluoro-3-methylphenyl)sulfonyl]-N-hydroxy-N~2~-methyl-D-alaninamide, ZINC ION | Authors: | Maize, K.M, Finzel, B.C. | Deposit date: | 2015-08-04 | Release date: | 2015-11-11 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Probing the S2' Subsite of the Anthrax Toxin Lethal Factor Using Novel N-Alkylated Hydroxamates. J.Med.Chem., 58, 2015
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6PSN
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![BU of 6psn by Molmil](/molmil-images/mine/6psn) | Anthrax toxin protective antigen channels bound to lethal factor | Descriptor: | CALCIUM ION, Lethal factor, Protective antigen | Authors: | Hardenbrook, N.J, Liu, S, Zhou, K, Zhou, Z.H, Krantz, B.A. | Deposit date: | 2019-07-12 | Release date: | 2020-03-04 | Last modified: | 2024-03-20 | Method: | ELECTRON MICROSCOPY (4.6 Å) | Cite: | Atomic structures of anthrax toxin protective antigen channels bound to partially unfolded lethal and edema factors. Nat Commun, 11, 2020
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