5D1S

Anthrax toxin lethal factor with hydroxamic acid inhibitor

Summary for 5D1S

Entry DOI	10.2210/pdb5d1s/pdb
Related	1YQY 4PKQ 4PKR 4PKS 4PKT 4PKU 4PKV 4PKW
Descriptor	Lethal factor, N~2~-[(4-fluoro-3-methylphenyl)sulfonyl]-N-hydroxy-N~2~-methyl-D-alaninamide, ZINC ION, ... (4 entities in total)
Functional Keywords	anthrax toxin, lethal factor, metalloproteinase, metalloprotease, structural dynamics, ligand-induced conformational change, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological source	Bacillus anthracis
Total number of polymer chains	1
Total formula weight	60791.77
Authors	Maize, K.M.,Finzel, B.C. (deposition date: 2015-08-04, release date: 2015-11-11, Last modification date: 2023-09-27)
Primary citation	Kurbanov, E.K.,Chiu, T.L.,Solberg, J.,Francis, S.,Maize, K.M.,Fernandez, J.,Johnson, R.L.,Hawkinson, J.E.,Walters, M.A.,Finzel, B.C.,Amin, E.A. Probing the S2' Subsite of the Anthrax Toxin Lethal Factor Using Novel N-Alkylated Hydroxamates. J.Med.Chem., 58:8723-8733, 2015 Cited by PubMed: 26492514 DOI: 10.1021/acs.jmedchem.5b01446 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.1 Å)

Structure validation