1YQY

Structure of B. Anthrax Lethal factor in complex with a hydroxamate inhibitor

Summary for 1YQY

• Entry DOI: 10.2210/pdb1yqy/pdb
• Descriptor: Lethal factor, ZINC ION, (2R)-2-{[(4-FLUORO-3-METHYLPHENYL)SULFONYL]AMINO}-N-HYDROXY-2-TETRAHYDRO-2H-PYRAN-4-YLACETAMIDE, ... (4 entities in total)
• Functional Keywords: toxin, lethal factor, inhibitors, hydroxamate, hydrolase
• Biological source: Bacillus anthracis
• Cellular location: Secreted: P15917
• Total number of polymer chains: 1
• Total formula weight: 61249.33

Authors

Shoop, W.L.,Xiong, Y.,Wiltsie, J.,Woods, A.,Guo, J.,Pivnichny, J.V.,Felcetto, T.,Michael, B.F.,Bansal, A. (deposition date: 2005-02-02, release date: 2005-05-31, Last modification date: 2023-08-23)

• Primary citation: Shoop, W.L.,Xiong, Y.,Wiltsie, J.,Woods, A.,Guo, J.,Pivnichny, J.V.,Felcetto, T.,Michael, B.F.,Bansal, A.,Cummings, R.T.,Cunningham, B.R.,Friedlander, A.M.,Douglas, C.M.,Patel, S.B.,Wisniewski, D.,Scapin, G.,Salowe, S.P.,Zaller, D.M.,Chapman, K.T.,Scolnick, E.M.,Schmatz, D.M.,Bartizal, K.,MacCoss, M.,Hermes, J.D.; Anthrax lethal factor inhibition.; Proc.Natl.Acad.Sci.Usa, 102:7958-7963, 2005; PubMed: 15911756; DOI: 10.1073/pnas.0502159102

Experimental method

X-RAY DIFFRACTION (2.3 Å)