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1PWP

Crystal Structure of the Anthrax Lethal Factor complexed with Small Molecule Inhibitor NSC 12155

Summary for 1PWP
Entry DOI10.2210/pdb1pwp/pdb
Related1PWQ
DescriptorLethal factor, ZINC ION, N,N'-BIS(4-AMINO-2-METHYLQUINOLIN-6-YL)UREA (3 entities in total)
Functional Keywordsanthrax toxin, lethal factor, small molecule inhibitor, hydrolase
Biological sourceBacillus anthracis
Cellular locationSecreted: P15917
Total number of polymer chains2
Total formula weight181589.29
Authors
Wong, T.Y.,Schwarzenbacher, R.,Liddington, R.C. (deposition date: 2003-07-02, release date: 2004-01-13, Last modification date: 2023-08-16)
Primary citationPanchal, R.G.,Hermone, A.R.,Nguyen, T.L.,Wong, T.Y.,Schwarzenbacher, R.,Schmidt, J.,Lane, D.,McGrath, C.,Turk, B.E.,Burnett, J.,Aman, M.J.,Little, S.,Sausville, E.A.,Zaharevitz, D.W.,Cantley, L.C.,Liddington, R.C.,Gussio, R.,Bavari, S.
Identification of small molecule inhibitors of anthrax lethal factor.
Nat.Struct.Mol.Biol., 11:67-72, 2004
Cited by
PubMed: 14718925
DOI: 10.1038/nsmb711
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.9 Å)
Structure validation

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