Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0003824 | molecular_function | catalytic activity |
A | 0004222 | molecular_function | metalloendopeptidase activity |
A | 0005515 | molecular_function | protein binding |
A | 0005576 | cellular_component | extracellular region |
A | 0006508 | biological_process | proteolysis |
A | 0008237 | molecular_function | metallopeptidase activity |
A | 0008270 | molecular_function | zinc ion binding |
A | 0030430 | cellular_component | host cell cytoplasm |
A | 0035821 | biological_process | modulation of process of another organism |
A | 0044164 | cellular_component | host cell cytosol |
A | 0046872 | molecular_function | metal ion binding |
A | 0090729 | molecular_function | toxin activity |
B | 0003824 | molecular_function | catalytic activity |
B | 0004222 | molecular_function | metalloendopeptidase activity |
B | 0005515 | molecular_function | protein binding |
B | 0005576 | cellular_component | extracellular region |
B | 0006508 | biological_process | proteolysis |
B | 0008237 | molecular_function | metallopeptidase activity |
B | 0008270 | molecular_function | zinc ion binding |
B | 0030430 | cellular_component | host cell cytoplasm |
B | 0035821 | biological_process | modulation of process of another organism |
B | 0044164 | cellular_component | host cell cytosol |
B | 0046872 | molecular_function | metal ion binding |
B | 0090729 | molecular_function | toxin activity |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE ZN A 9001 |
Chain | Residue |
A | HIS686 |
A | HIS690 |
A | TYR728 |
A | GLU735 |
A | NSC9002 |
site_id | AC2 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE ZN B 9002 |
Chain | Residue |
B | NSC9003 |
B | HIS686 |
B | HIS690 |
B | TYR728 |
B | GLU735 |
site_id | AC3 |
Number of Residues | 9 |
Details | BINDING SITE FOR RESIDUE NSC A 9002 |
Chain | Residue |
A | ASP328 |
A | PHE329 |
A | SER655 |
A | TYR659 |
A | GLU687 |
A | HIS690 |
A | TYR728 |
A | GLU735 |
A | ZN9001 |
site_id | AC4 |
Number of Residues | 11 |
Details | BINDING SITE FOR RESIDUE NSC B 9003 |
Chain | Residue |
B | SER655 |
B | LYS656 |
B | GLY657 |
B | LEU658 |
B | TYR659 |
B | VAL675 |
B | GLU687 |
B | HIS690 |
B | TYR728 |
B | GLU735 |
B | ZN9002 |
Functional Information from PROSITE/UniProt
site_id | PS00142 |
Number of Residues | 10 |
Details | ZINC_PROTEASE Neutral zinc metallopeptidases, zinc-binding region signature. GFIHEFGHAV |
Chain | Residue | Details |
A | GLY683-VAL692 | |
Functional Information from SwissProt/UniProt
Chain | Residue | Details |
A | GLU687 | |
B | GLU687 | |
site_id | SWS_FT_FI2 |
Number of Residues | 6 |
Details | BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU01339, ECO:0000269|PubMed:11700563, ECO:0000269|PubMed:14718924, ECO:0000269|PubMed:14718925, ECO:0000269|PubMed:15911756, ECO:0000269|PubMed:22342144, ECO:0000269|PubMed:25372673, ECO:0000269|PubMed:26492514, ECO:0000269|PubMed:26578066, ECO:0007744|PDB:1J7N, ECO:0007744|PDB:1PWP, ECO:0007744|PDB:1PWQ, ECO:0007744|PDB:1PWU, ECO:0007744|PDB:1PWW, ECO:0007744|PDB:1YQY, ECO:0007744|PDB:4DV8, ECO:0007744|PDB:4PKQ, ECO:0007744|PDB:4PKR, ECO:0007744|PDB:4PKS, ECO:0007744|PDB:4PKT, ECO:0007744|PDB:4PKV, ECO:0007744|PDB:4PKW, ECO:0007744|PDB:4WF6, ECO:0007744|PDB:4XM6, ECO:0007744|PDB:4XM7, ECO:0007744|PDB:5D1S, ECO:0007744|PDB:5D1T |
Chain | Residue | Details |
A | HIS686 | |
A | HIS690 | |
A | GLU735 | |
B | HIS686 | |
B | HIS690 | |
B | GLU735 | |
Chain | Residue | Details |
A | TYR728 | |
B | TYR728 | |
Catalytic Information from CSA
site_id | CSA1 |
Number of Residues | 2 |
Details | Annotated By Reference To The Literature 1pwv |
Chain | Residue | Details |
A | GLU687 | |
A | TYR728 | |
site_id | CSA2 |
Number of Residues | 2 |
Details | Annotated By Reference To The Literature 1pwv |
Chain | Residue | Details |
B | GLU687 | |
B | TYR728 | |
site_id | CSA3 |
Number of Residues | 1 |
Details | Annotated By Reference To The Literature 1pwv |
Chain | Residue | Details |
A | LYS518 | |
site_id | CSA4 |
Number of Residues | 1 |
Details | Annotated By Reference To The Literature 1pwv |
Chain | Residue | Details |
B | LYS518 | |
site_id | MCSA1 |
Number of Residues | 5 |
Details | M-CSA 641 |
Chain | Residue | Details |
A | HIS686 | metal ligand |
A | GLU687 | proton acceptor, proton donor |
A | HIS690 | metal ligand |
A | TYR728 | electrostatic stabiliser |
A | GLU735 | metal ligand |
site_id | MCSA2 |
Number of Residues | 5 |
Details | M-CSA 641 |
Chain | Residue | Details |
B | HIS686 | metal ligand |
B | GLU687 | proton acceptor, proton donor |
B | HIS690 | metal ligand |
B | TYR728 | electrostatic stabiliser |
B | GLU735 | metal ligand |