4WF6

Anthrax toxin lethal factor with bound small molecule inhibitor MK-31

Summary for 4WF6

Entry DOI	10.2210/pdb4wf6/pdb
Related	1YQY 4PKQ 4PKR 4PKS 4PKT 4PKU 4PKV 4PKW 5D1S 5D1T 5D1U
Descriptor	Lethal factor, ZINC ION, N~2~-[(4-fluoro-3-methylphenyl)sulfonyl]-N-hydroxy-D-alaninamide, ... (5 entities in total)
Functional Keywords	anthrax toxin, lethal factor, metalloproteinase, metalloprotease, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological source	Bacillus anthracis
Total number of polymer chains	1
Total formula weight	60839.81
Authors	Maize, K.M.,De la Mora-Rey, T.,Finzel, B.C. (deposition date: 2014-09-12, release date: 2015-09-09, Last modification date: 2023-09-27)
Primary citation	Kurbanov, E.K.,Chiu, T.L.,Solberg, J.,Francis, S.,Maize, K.M.,Fernandez, J.,Johnson, R.L.,Hawkinson, J.E.,Walters, M.A.,Finzel, B.C.,Amin, E.A. Probing the S2' Subsite of the Anthrax Toxin Lethal Factor Using Novel N-Alkylated Hydroxamates. J.Med.Chem., 58:8723-8733, 2015 Cited by PubMed: 26492514 DOI: 10.1021/acs.jmedchem.5b01446 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.6521 Å)

Structure validation