5D1U
Anthrax toxin lethal factor with hydroxamic acid inhibitor
Summary for 5D1U
Entry DOI | 10.2210/pdb5d1u/pdb |
Related | 1YQY 4PKQ 4PKR 4PKS 4PKT 4PKU 4PKV 4PKW |
Descriptor | Lethal factor, N~2~-(6-aminohexyl)-N~2~-[(4-fluoro-3-methylphenyl)sulfonyl]-N-hydroxy-D-alaninamide, ZINC ION, ... (4 entities in total) |
Functional Keywords | anthrax toxin, lethal factor, metalloproteinase, metalloprotease, structural dynamics, ligand-induced conformational change, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
Biological source | Bacillus anthracis |
Total number of polymer chains | 1 |
Total formula weight | 60876.92 |
Authors | Maize, K.M.,Finzel, B.C. (deposition date: 2015-08-04, release date: 2015-11-11, Last modification date: 2023-09-27) |
Primary citation | Kurbanov, E.K.,Chiu, T.L.,Solberg, J.,Francis, S.,Maize, K.M.,Fernandez, J.,Johnson, R.L.,Hawkinson, J.E.,Walters, M.A.,Finzel, B.C.,Amin, E.A. Probing the S2' Subsite of the Anthrax Toxin Lethal Factor Using Novel N-Alkylated Hydroxamates. J.Med.Chem., 58:8723-8733, 2015 Cited by PubMed: 26492514DOI: 10.1021/acs.jmedchem.5b01446 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.8503 Å) |
Structure validation
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