4PKV

Anthrax toxin lethal factor with bound small molecule inhibitor 16

Summary for 4PKV

Entry DOI	10.2210/pdb4pkv/pdb
Related	1J7N 1JKY 1PWP 1PWQ 1PWU 1PWV 1PWW 1YQY 1ZXV 4DV8 4PKQ 4PKR 4PKS 4PKT 4PKU 4PKW
Descriptor	Lethal factor, N~2~-[4-(aminomethyl)benzyl]-N~2~-[(4-fluoro-3-methylphenyl)sulfonyl]-N-hydroxy-D-alaninamide, ZINC ION, ... (4 entities in total)
Functional Keywords	anthrax toxin, lethal factor, metalloproteinase, metalloprotease, structural dynamics, ligand-induced conformational change, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological source	Bacillus anthracis
Total number of polymer chains	1
Total formula weight	60896.90
Authors	Maize, K.M.,Finzel, B.C. (deposition date: 2014-05-15, release date: 2014-11-12, Last modification date: 2023-12-27)
Primary citation	Maize, K.M.,Kurbanov, E.K.,De La Mora-Rey, T.,Geders, T.W.,Hwang, D.J.,Walters, M.A.,Johnson, R.L.,Amin, E.A.,Finzel, B.C. Anthrax toxin lethal factor domain 3 is highly mobile and responsive to ligand binding. Acta Crystallogr.,Sect.D, 70:2813-2822, 2014 Cited by PubMed: 25372673 DOI: 10.1107/S1399004714018161 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.5 Å)

Structure validation