1PWP
Crystal Structure of the Anthrax Lethal Factor complexed with Small Molecule Inhibitor NSC 12155
Summary for 1PWP
Entry DOI | 10.2210/pdb1pwp/pdb |
Related | 1PWQ |
Descriptor | Lethal factor, ZINC ION, N,N'-BIS(4-AMINO-2-METHYLQUINOLIN-6-YL)UREA (3 entities in total) |
Functional Keywords | anthrax toxin, lethal factor, small molecule inhibitor, hydrolase |
Biological source | Bacillus anthracis |
Cellular location | Secreted: P15917 |
Total number of polymer chains | 2 |
Total formula weight | 181589.29 |
Authors | Wong, T.Y.,Schwarzenbacher, R.,Liddington, R.C. (deposition date: 2003-07-02, release date: 2004-01-13, Last modification date: 2023-08-16) |
Primary citation | Panchal, R.G.,Hermone, A.R.,Nguyen, T.L.,Wong, T.Y.,Schwarzenbacher, R.,Schmidt, J.,Lane, D.,McGrath, C.,Turk, B.E.,Burnett, J.,Aman, M.J.,Little, S.,Sausville, E.A.,Zaharevitz, D.W.,Cantley, L.C.,Liddington, R.C.,Gussio, R.,Bavari, S. Identification of small molecule inhibitors of anthrax lethal factor. Nat.Struct.Mol.Biol., 11:67-72, 2004 Cited by PubMed: 14718925DOI: 10.1038/nsmb711 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.9 Å) |
Structure validation
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