4XM8

Anthrax toxin lethal factor with ligand-induced binding pocket

Summary for 4XM8

Entry DOI	10.2210/pdb4xm8/pdb
Related	1YQY 4PKQ 4PKR 4PKS 4PKT 4PKU 4PKV 4PKW 4WF6 4XM6 4XM7
Descriptor	Lethal factor, N-hydroxy-N~2~-{[3-(methoxymethyl)phenyl]sulfonyl}-N~2~-(2-methylpropyl)-D-valinamide, ZINC ION, ... (4 entities in total)
Functional Keywords	anthrax toxin, lethal factor, metalloproteinase, metalloprotease, structural dynamics, ligand-induced conformational change, toxin, hydrolase
Biological source	Bacillus anthracis
Total number of polymer chains	1
Total formula weight	60873.94
Authors	Maize, K.M.,Finzel, B.C. (deposition date: 2015-01-14, release date: 2015-11-11, Last modification date: 2023-09-27)
Primary citation	Maize, K.M.,Kurbanov, E.K.,Johnson, R.L.,Amin, E.A.,Finzel, B.C. Ligand-induced expansion of the S1' site in the anthrax toxin lethal factor. Febs Lett., 589:3836-3841, 2015 Cited by PubMed: 26578066 DOI: 10.1016/j.febslet.2015.11.005 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.7 Å)

Structure validation