1ZXV

X-Ray Crystal Structure of the Anthrax Lethal Factor Bound to a Small Molecule Inhibitor, BI-MFM3, 3-{5-[5-(4-Chloro-phenyl)-furan-2-ylmethylene]-4-oxo-2-thioxo-thiazolidin-3-yl}-propionic acid.

Summary for 1ZXV

• Entry DOI: 10.2210/pdb1zxv/pdb
• Descriptor: lethal factor, ZINC ION, (E)-3-(5((5-(4-CHLOROPHENYL)FURAN-2-YL)METHYLENE)-4-OXO-2-THIOXOTHIAZOLIDIN-3-YL)PROPANOIC ACID (3 entities in total)
• Functional Keywords: anthrax toxin lethal factor, protein and small molecule inhibitor complex, zinc metalloproteinase, hydrolase
• Biological source: Bacillus anthracis
• Total number of polymer chains: 2
• Total formula weight: 181632.17

Authors

Wong, T.Y.,Liddington, R.C. (deposition date: 2005-06-08, release date: 2005-07-05, Last modification date: 2024-03-13)

• Primary citation: Forino, M.,Johnson, S.,Wong, T.Y.,Rozanov, D.V.,Savinov, A.Y.,Li, W.,Fattorusso, R.,Becattini, B.,Orry, A.J.,Jung, D.,Abagyan, R.A.,Smith, J.W.,Alibek, K.,Liddington, R.C.,Strongin, A.Y.,Pellecchia, M.; Efficient synthetic inhibitors of anthrax lethal factor.; Proc.Natl.Acad.Sci.Usa, 102:9499-9504, 2005; PubMed: 15983377; DOI: 10.1073/pnas.0502733102

Experimental method

X-RAY DIFFRACTION (2.67 Å)