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1ZXV

X-Ray Crystal Structure of the Anthrax Lethal Factor Bound to a Small Molecule Inhibitor, BI-MFM3, 3-{5-[5-(4-Chloro-phenyl)-furan-2-ylmethylene]-4-oxo-2-thioxo-thiazolidin-3-yl}-propionic acid.

Functional Information from GO Data
ChainGOidnamespacecontents
A0003824molecular_functioncatalytic activity
A0004222molecular_functionmetalloendopeptidase activity
A0005515molecular_functionprotein binding
A0005576cellular_componentextracellular region
A0006508biological_processproteolysis
A0008233molecular_functionpeptidase activity
A0008237molecular_functionmetallopeptidase activity
A0008270molecular_functionzinc ion binding
A0016787molecular_functionhydrolase activity
A0035821biological_processmodulation of process of another organism
A0044164cellular_componenthost cell cytosol
A0046872molecular_functionmetal ion binding
A0090729molecular_functiontoxin activity
B0003824molecular_functioncatalytic activity
B0004222molecular_functionmetalloendopeptidase activity
B0005515molecular_functionprotein binding
B0005576cellular_componentextracellular region
B0006508biological_processproteolysis
B0008233molecular_functionpeptidase activity
B0008237molecular_functionmetallopeptidase activity
B0008270molecular_functionzinc ion binding
B0016787molecular_functionhydrolase activity
B0035821biological_processmodulation of process of another organism
B0044164cellular_componenthost cell cytosol
B0046872molecular_functionmetal ion binding
B0090729molecular_functiontoxin activity
Functional Information from PDB Data
site_idAC1
Number of Residues5
DetailsBINDING SITE FOR RESIDUE ZN A 9001
ChainResidue
AHIS686
AHIS690
ATYR728
AGLU735
AMFM9002

site_idAC2
Number of Residues5
DetailsBINDING SITE FOR RESIDUE ZN B 9002
ChainResidue
BMFM9003
BHIS686
BHIS690
BTYR728
BGLU735

site_idAC3
Number of Residues10
DetailsBINDING SITE FOR RESIDUE MFM A 9002
ChainResidue
ASER655
AGLY657
ALEU658
ATYR659
AGLU662
AGLU687
AHIS690
ATYR728
AGLU735
AZN9001

site_idAC4
Number of Residues10
DetailsBINDING SITE FOR RESIDUE MFM B 9003
ChainResidue
BSER655
BGLY657
BPRO661
BGLU662
BHIS686
BGLU687
BHIS690
BTYR728
BGLU735
BZN9002

Functional Information from PROSITE/UniProt
site_idPS00142
Number of Residues10
DetailsZINC_PROTEASE Neutral zinc metallopeptidases, zinc-binding region signature. GFIHEFGHAV
ChainResidueDetails
AGLY683-VAL692

Catalytic Information from CSA
site_idCSA1
Number of Residues2
DetailsAnnotated By Reference To The Literature 1pwv
ChainResidueDetails
AGLU687
ATYR728

site_idCSA2
Number of Residues2
DetailsAnnotated By Reference To The Literature 1pwv
ChainResidueDetails
BGLU687
BTYR728

site_idCSA3
Number of Residues1
DetailsAnnotated By Reference To The Literature 1pwv
ChainResidueDetails
ALYS518

site_idCSA4
Number of Residues1
DetailsAnnotated By Reference To The Literature 1pwv
ChainResidueDetails
BLYS518

250835

PDB entries from 2026-03-18

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