4DV8
Anthrax Lethal Factor metalloproteinase in complex with the Hydroxamic acid based small molecule PT8421
Summary for 4DV8
Entry DOI | 10.2210/pdb4dv8/pdb |
Descriptor | Lethal factor, ZINC ION, (2S)-6-[(4-fluorobenzyl)amino]-2-[(2R)-2-(4-fluorophenyl)-2-methoxyethyl]-N-hydroxyhexanamide, ... (5 entities in total) |
Functional Keywords | endopeptidase, zinc dependent, hydrolase |
Biological source | Bacillus anthracis (anthrax,anthrax bacterium) |
Cellular location | Secreted: P15917 |
Total number of polymer chains | 1 |
Total formula weight | 61965.03 |
Authors | Margosiak, S.A.,Sankaran, B. (deposition date: 2012-02-22, release date: 2012-03-14, Last modification date: 2024-02-28) |
Primary citation | Jiao, G.S.,Kim, S.,Moayeri, M.,Crown, D.,Thai, A.,Cregar-Hernandez, L.,McKasson, L.,Sankaran, B.,Lehrer, A.,Wong, T.,Johns, L.,Margosiak, S.A.,Leppla, S.H.,Johnson, A.T. Antidotes to anthrax lethal factor intoxication. Part 3: Evaluation of core structures and further modifications to the C2-side chain. Bioorg.Med.Chem.Lett., 22:2242-, 2012 Cited by PubMed: 22342144DOI: 10.1016/j.bmcl.2012.01.095 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.632 Å) |
Structure validation
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