7NWH
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![BU of 7nwh by Molmil](/molmil-images/mine/7nwh) | Mammalian pre-termination 80S ribosome with eRF1 and eRF3 bound by Blasticidin S. | Descriptor: | 18S Ribosomal RNA, 28S Ribosomal RNA, 40S ribosomal protein S10, ... | Authors: | Powers, K.T, Yadav, S.K.N, Bufton, J.C, Schaffitzel, C. | Deposit date: | 2021-03-16 | Release date: | 2021-07-07 | Last modified: | 2023-01-11 | Method: | ELECTRON MICROSCOPY (4.1 Å) | Cite: | Blasticidin S inhibits mammalian translation and enhances production of protein encoded by nonsense mRNA. Nucleic Acids Res., 49, 2021
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7D80
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![BU of 7d80 by Molmil](/molmil-images/mine/7d80) | Molecular model of the cryo-EM structure of 70S ribosome in complex with peptide deformylase, trigger factor, and methionine aminopeptidase | Descriptor: | 16S ribosomal RNA, 23S ribosomal RNA, 30S ribosomal protein S10, ... | Authors: | Akbar, S, Bhakta, S, Sengupta, J. | Deposit date: | 2020-10-06 | Release date: | 2021-04-07 | Last modified: | 2024-05-29 | Method: | ELECTRON MICROSCOPY (4.1 Å) | Cite: | Structural insights into the interplay of protein biogenesis factors with the 70S ribosome. Structure, 29, 2021
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6ND1
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![BU of 6nd1 by Molmil](/molmil-images/mine/6nd1) | CryoEM structure of the Sec Complex from yeast | Descriptor: | Protein translocation protein SEC63, Protein transport protein SBH1, Protein transport protein SEC61, ... | Authors: | Wu, X, Cabanos, C, Rapoport, T.A. | Deposit date: | 2018-12-13 | Release date: | 2019-01-09 | Last modified: | 2024-03-20 | Method: | ELECTRON MICROSCOPY (4.1 Å) | Cite: | Structure of the post-translational protein translocation machinery of the ER membrane. Nature, 566, 2019
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5ANB
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![BU of 5anb by Molmil](/molmil-images/mine/5anb) | Mechanism of eIF6 release from the nascent 60S ribosomal subunit | Descriptor: | 26S RIBOSOMAL RNA, 60S ACIDIC RIBOSOMAL PROTEIN P0, 60S RIBOSOMAL PROTEIN L10, ... | Authors: | Weis, F, Giudice, E, Churcher, M, Jin, L, Hilcenko, C, Wong, C.C, Traynor, D, Kay, R.R, Warren, A.J. | Deposit date: | 2015-09-06 | Release date: | 2015-10-21 | Last modified: | 2024-05-08 | Method: | ELECTRON MICROSCOPY (4.1 Å) | Cite: | Mechanism of Eif6 Release from the Nascent 60S Ribosomal Subunit Nat.Struct.Mol.Biol., 22, 2015
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7KAP
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![BU of 7kap by Molmil](/molmil-images/mine/7kap) | Cryo-EM structure of the Sec complex from S. cerevisiae, Sec61 pore mutant, class with Sec62, conformation 1 (C1) | Descriptor: | Protein translocation protein SEC63, Protein transport protein SBH1, Protein transport protein SEC61, ... | Authors: | Itskanov, S, Park, E. | Deposit date: | 2020-10-01 | Release date: | 2021-01-06 | Last modified: | 2024-03-06 | Method: | ELECTRON MICROSCOPY (4.1 Å) | Cite: | Stepwise gating of the Sec61 protein-conducting channel by Sec63 and Sec62. Nat.Struct.Mol.Biol., 28, 2021
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6GZZ
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![BU of 6gzz by Molmil](/molmil-images/mine/6gzz) | T. thermophilus hibernating 100S ribosome (amc) | Descriptor: | 16S ribosomal RNA, 23S ribosomal RNA, 30S ribosomal protein S10, ... | Authors: | Flygaard, R.K, Jenner, L.B. | Deposit date: | 2018-07-05 | Release date: | 2018-10-24 | Last modified: | 2024-05-15 | Method: | ELECTRON MICROSCOPY (4.13 Å) | Cite: | Cryo-EM structure of the hibernating Thermus thermophilus 100S ribosome reveals a protein-mediated dimerization mechanism. Nat Commun, 9, 2018
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5O31
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![BU of 5o31 by Molmil](/molmil-images/mine/5o31) | Mitochondrial complex I in the deactive state | Descriptor: | Acyl carrier protein, mitochondrial, FE2/S2 (INORGANIC) CLUSTER, ... | Authors: | Blaza, J.N, Vinothkumar, K.R, Hirst, J. | Deposit date: | 2017-05-23 | Release date: | 2018-01-17 | Last modified: | 2019-10-23 | Method: | ELECTRON MICROSCOPY (4.13 Å) | Cite: | Structure of the Deactive State of Mammalian Respiratory Complex I. Structure, 26, 2018
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6OSI
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![BU of 6osi by Molmil](/molmil-images/mine/6osi) | Unmodified tRNA(Pro) bound to Thermus thermophilus 70S (near cognate) | Descriptor: | 16S rRNA, 23S rRNA, 30S ribosomal protein S10, ... | Authors: | Hoffer, E.D, Subaramanian, S, Hong, S, Maehigashi, T, Dunham, C.M. | Deposit date: | 2019-05-01 | Release date: | 2020-10-14 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (4.14 Å) | Cite: | Structural insights into mRNA reading frame regulation by tRNA modification and slippery codon-anticodon pairing. Elife, 9, 2020
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6O8Y
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![BU of 6o8y by Molmil](/molmil-images/mine/6o8y) | |
7UPH
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![BU of 7uph by Molmil](/molmil-images/mine/7uph) | Structure of a ribosome with tethered subunits | Descriptor: | 30S ribosomal protein S10, 30S ribosomal protein S11, 30S ribosomal protein S12, ... | Authors: | Kim, D.S, Watkins, A, Bidstrup, E, Lee, J, Topkar, V.V, Kofman, C, Schwarz, K.J, Liu, Y, Pintilie, G, Roney, E, Das, R, Jewett, M.C. | Deposit date: | 2022-04-15 | Release date: | 2022-08-17 | Last modified: | 2022-08-31 | Method: | ELECTRON MICROSCOPY (4.18 Å) | Cite: | Three-dimensional structure-guided evolution of a ribosome with tethered subunits. Nat.Chem.Biol., 18, 2022
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8GZU
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![BU of 8gzu by Molmil](/molmil-images/mine/8gzu) | Cryo-EM structure of Tetrahymena thermophila respiratory Megacomplex MC (IV2+I+III2+II)2 | Descriptor: | 2 iron, 2 sulfur cluster-binding protein, 2-oxoglutarate/malate carrier protein, ... | Authors: | Wu, M.C, Hu, Y.Q, Han, F.Z, Zhou, L. | Deposit date: | 2022-09-27 | Release date: | 2023-06-14 | Method: | ELECTRON MICROSCOPY (4.18 Å) | Cite: | Structures of Tetrahymena thermophila respiratory megacomplexes on the tubular mitochondrial cristae. Nat Commun, 14, 2023
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6OST
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![BU of 6ost by Molmil](/molmil-images/mine/6ost) | RF2 pre-accommodated state bound Release complex 70S at 24ms | Descriptor: | 16S Ribosomal RNA, 23S Ribosomal RNA, 30S ribosomal protein S10, ... | Authors: | Fu, Z, Indrisiunaite, G, Kaledhonkar, S, Shah, B, Sun, M, Chen, B, Grassucci, R.A, Ehrenberg, M, Frank, J. | Deposit date: | 2019-05-02 | Release date: | 2019-06-19 | Last modified: | 2019-12-18 | Method: | ELECTRON MICROSCOPY (4.2 Å) | Cite: | The structural basis for release-factor activation during translation termination revealed by time-resolved cryogenic electron microscopy. Nat Commun, 10, 2019
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6OGG
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![BU of 6ogg by Molmil](/molmil-images/mine/6ogg) | 70S termination complex with RF2 bound to the UGA codon. Rotated ribosome with RF2 bound (Structure IV). | Descriptor: | 16S ribosomal RNA, 23S ribosomal RNA, 30S ribosomal protein S10, ... | Authors: | Svidritskiy, E, Demo, G, Loveland, A.B, Xu, C, Korostelev, A.A. | Deposit date: | 2019-04-02 | Release date: | 2019-09-25 | Last modified: | 2024-03-20 | Method: | ELECTRON MICROSCOPY (4.2 Å) | Cite: | Extensive ribosome and RF2 rearrangements during translation termination. Elife, 8, 2019
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5T6R
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![BU of 5t6r by Molmil](/molmil-images/mine/5t6r) | Nmd3 is a structural mimic of eIF5A, and activates the cpGTPase Lsg1 during 60S ribosome biogenesis: 60S-Nmd3 Complex | Descriptor: | 25S Ribosomal RNA, 5.8S Ribosomal RNA, 5S Ribosomal RNA, ... | Authors: | Malyutin, A.G, Musalgaonkar, S, Patchett, S, Frank, J, Johnson, A.W. | Deposit date: | 2016-09-01 | Release date: | 2017-02-08 | Last modified: | 2024-03-13 | Method: | ELECTRON MICROSCOPY (4.2 Å) | Cite: | Nmd3 is a structural mimic of eIF5A, and activates the cpGTPase Lsg1 during 60S ribosome biogenesis. EMBO J., 36, 2017
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5ANC
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![BU of 5anc by Molmil](/molmil-images/mine/5anc) | Mechanism of eIF6 release from the nascent 60S ribosomal subunit | Descriptor: | 26S RIBOSOMAL RNA, 60S ACIDIC RIBOSOMAL PROTEIN P0, 60S RIBOSOMAL PROTEIN L10, ... | Authors: | Weis, F, Giudice, E, Churcher, M, Jin, L, Hilcenko, C, Wong, C.C, Traynor, D, Kay, R.R, Warren, A.J. | Deposit date: | 2015-09-06 | Release date: | 2015-10-21 | Last modified: | 2017-08-02 | Method: | ELECTRON MICROSCOPY (4.2 Å) | Cite: | Mechanism of Eif6 Release from the Nascent 60S Ribosomal Subunit Nat.Struct.Mol.Biol., 22, 2015
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6FTI
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![BU of 6fti by Molmil](/molmil-images/mine/6fti) | Cryo-EM Structure of the Mammalian Oligosaccharyltransferase Bound to Sec61 and the Programmed 80S Ribosome | Descriptor: | 28S rRNA, 5.8S ribosomal RNA, 5S ribosomal RNA, ... | Authors: | Braunger, K, Becker, T, Beckmann, R. | Deposit date: | 2018-02-22 | Release date: | 2018-03-21 | Last modified: | 2020-07-29 | Method: | ELECTRON MICROSCOPY (4.2 Å) | Cite: | Structural basis for coupling protein transport and N-glycosylation at the mammalian endoplasmic reticulum. Science, 360, 2018
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5JUS
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![BU of 5jus by Molmil](/molmil-images/mine/5jus) | Saccharomyces cerevisiae 80S ribosome bound with elongation factor eEF2-GDP-sordarin and Taura Syndrome Virus IRES, Structure III (mid-rotated 40S subunit) | Descriptor: | 18S ribosomal RNA, 25S ribosomal RNA, 5.8S ribosomal RNA, ... | Authors: | Abeyrathne, P, Koh, C.S, Grant, T, Grigorieff, N, Korostelev, A.A. | Deposit date: | 2016-05-10 | Release date: | 2016-10-05 | Last modified: | 2023-04-05 | Method: | ELECTRON MICROSCOPY (4.2 Å) | Cite: | Ensemble cryo-EM uncovers inchworm-like translocation of a viral IRES through the ribosome. Elife, 5, 2016
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6WDC
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![BU of 6wdc by Molmil](/molmil-images/mine/6wdc) | Cryo-EM of elongating ribosome with EF-Tu*GTP elucidates tRNA proofreading (Cognate Structure IV-B) | Descriptor: | 16S ribosomal RNA, 23S ribosomal RNA, 30S ribosomal protein S10, ... | Authors: | Loveland, A.B, Demo, G, Korostelev, A.A. | Deposit date: | 2020-03-31 | Release date: | 2020-07-01 | Last modified: | 2024-03-06 | Method: | ELECTRON MICROSCOPY (4.2 Å) | Cite: | Cryo-EM of elongating ribosome with EF-Tu•GTP elucidates tRNA proofreading. Nature, 584, 2020
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7DH0
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![BU of 7dh0 by Molmil](/molmil-images/mine/7dh0) | Activity optimized complex I (open form) | Descriptor: | 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 1,2-Distearoyl-sn-glycerophosphoethanolamine, Acyl carrier protein, ... | Authors: | Jeon, T.J, Lee, S.G, Yoo, S.H, Ryu, J.H, Kim, D.S, Hyun, J.K, Kim, H.M, Ryu, S.E. | Deposit date: | 2020-11-12 | Release date: | 2022-05-18 | Method: | ELECTRON MICROSCOPY (4.2 Å) | Cite: | A Dynamic Substrate Pool Revealed by cryo-EM of a Lipid-Preserved Respiratory Supercomplex. Antioxid.Redox Signal., 2022
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4BSK
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![BU of 4bsk by Molmil](/molmil-images/mine/4bsk) | Crystal structure of VEGF-C in complex with VEGFR-3 domains D1-2 | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, VASCULAR ENDOTHELIAL GROWTH FACTOR C, ... | Authors: | Leppanen, V.M, Tvorogov, D, Kisko, K, Prota, A.E, Jeltsch, M, Anisimov, A, Markovic-Mueller, S, Stuttfeld, E, Goldie, K.N, Ballmer-Hofer, K, Alitalo, K. | Deposit date: | 2013-06-10 | Release date: | 2013-07-31 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (4.201 Å) | Cite: | Structural and Mechanistic Insights Into Vegfr-3 Ligand Binding and Activation Proc.Natl.Acad.Sci.USA, 110, 2013
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6ZIY
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![BU of 6ziy by Molmil](/molmil-images/mine/6ziy) | Respiratory complex I from Thermus thermophilus, NADH dataset, major state | Descriptor: | 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE, FE2/S2 (INORGANIC) CLUSTER, FLAVIN MONONUCLEOTIDE, ... | Authors: | Kaszuba, K, Tambalo, M, Gallagher, G.T, Sazanov, L.A. | Deposit date: | 2020-06-26 | Release date: | 2020-09-02 | Method: | ELECTRON MICROSCOPY (4.25 Å) | Cite: | Key role of quinone in the mechanism of respiratory complex I. Nat Commun, 11, 2020
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5LDW
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![BU of 5ldw by Molmil](/molmil-images/mine/5ldw) | Structure of mammalian respiratory Complex I, class1 | Descriptor: | Acyl carrier protein, mitochondrial, FE2/S2 (INORGANIC) CLUSTER, ... | Authors: | Vinothkumar, K.R, Zhu, J, Hirst, J. | Deposit date: | 2016-06-28 | Release date: | 2016-09-07 | Last modified: | 2019-10-23 | Method: | ELECTRON MICROSCOPY (4.27 Å) | Cite: | Structure of mammalian respiratory complex I. Nature, 536, 2016
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4V8Y
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![BU of 4v8y by Molmil](/molmil-images/mine/4v8y) | Cryo-EM reconstruction of the 80S-eIF5B-Met-itRNAMet Eukaryotic Translation Initiation Complex | Descriptor: | 18S RIBOSOMAL RNA, 25S RIBOSOMAL RNA, 40S RIBOSOMAL PROTEIN S0-A, ... | Authors: | Fernandez, I.S, Bai, X.C, Hussain, T, Kelley, A.C, Lorsch, J.R, Ramakrishnan, V, Scheres, S.H.W. | Deposit date: | 2013-07-20 | Release date: | 2014-07-09 | Last modified: | 2024-06-26 | Method: | ELECTRON MICROSCOPY (4.3 Å) | Cite: | Molecular architecture of a eukaryotic translational initiation complex. Science, 342, 2013
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6ZJL
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![BU of 6zjl by Molmil](/molmil-images/mine/6zjl) | Respiratory complex I from Thermus thermophilus, NAD+ dataset, major state | Descriptor: | FE2/S2 (INORGANIC) CLUSTER, FLAVIN MONONUCLEOTIDE, IRON/SULFUR CLUSTER, ... | Authors: | Kaszuba, K, Tambalo, M, Gallagher, G.T, Sazanov, L.A. | Deposit date: | 2020-06-29 | Release date: | 2020-09-02 | Method: | ELECTRON MICROSCOPY (4.3 Å) | Cite: | Key role of quinone in the mechanism of respiratory complex I. Nat Commun, 11, 2020
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6EM5
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![BU of 6em5 by Molmil](/molmil-images/mine/6em5) | State D architectural model (Nsa1-TAP Flag-Ytm1) - Visualizing the assembly pathway of nucleolar pre-60S ribosomes | Descriptor: | 25S rRNA (cytosine(2870)-C(5))-methyltransferase, 25S ribosomal RNA, 27S pre-rRNA (guanosine(2922)-2'-O)-methyltransferase, ... | Authors: | Kater, L, Cheng, J, Barrio-Garcia, C, Hurt, E, Beckmann, R. | Deposit date: | 2017-10-01 | Release date: | 2017-12-27 | Last modified: | 2024-05-08 | Method: | ELECTRON MICROSCOPY (4.3 Å) | Cite: | Visualizing the Assembly Pathway of Nucleolar Pre-60S Ribosomes. Cell, 171, 2017
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