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8GZU

Cryo-EM structure of Tetrahymena thermophila respiratory Megacomplex MC (IV2+I+III2+II)2

これはPDB形式変換不可エントリーです。
8GZU の概要
エントリーDOI10.2210/pdb8gzu/pdb
EMDBエントリー34403 34404 34405
分子名称Transmembrane protein, putative, COXTT10, Ymf65, ... (164 entities in total)
機能のキーワードelectron transport chain, supercomplex, membrane protein, tetrahymena thermophila, electron transport
由来する生物種Tetrahymena thermophila SB210
詳細
タンパク質・核酸の鎖数436
化学式量合計11803642.70
構造登録者
Wu, M.C.,Hu, Y.Q.,Han, F.Z.,Zhou, L. (登録日: 2022-09-27, 公開日: 2023-06-14, 最終更新日: 2024-10-16)
主引用文献Han, F.,Hu, Y.,Wu, M.,He, Z.,Tian, H.,Zhou, L.
Structures of Tetrahymena thermophila respiratory megacomplexes on the tubular mitochondrial cristae.
Nat Commun, 14:2542-2542, 2023
Cited by
PubMed Abstract: Tetrahymena thermophila, a classic ciliate model organism, has been shown to possess tubular mitochondrial cristae and highly divergent electron transport chain involving four transmembrane protein complexes (I-IV). Here we report cryo-EM structures of its ~8 MDa megacomplex IV+ (I + III+ II), as well as a ~ 10.6 MDa megacomplex (IV + I + III+ II) at lower resolution. In megacomplex IV+ (I + III+ II), each CIV protomer associates one copy of supercomplex I + III and one copy of CII, forming a half ring-shaped architecture that adapts to the membrane curvature of mitochondrial cristae. Megacomplex (IV+ I + III+ II) defines the relative position between neighbouring half rings and maintains the proximity between CIV and CIII cytochrome c binding sites. Our findings expand the current understanding of divergence in eukaryotic electron transport chain organization and how it is related to mitochondrial morphology.
PubMed: 37248254
DOI: 10.1038/s41467-023-38158-5
主引用文献が同じPDBエントリー
実験手法
ELECTRON MICROSCOPY (4.18 Å)
構造検証レポート
Validation report summary of 8gzu
検証レポート(詳細版)ダウンロードをダウンロード

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件を2025-04-02に公開中

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