8GZU
Cryo-EM structure of Tetrahymena thermophila respiratory Megacomplex MC (IV2+I+III2+II)2
これはPDB形式変換不可エントリーです。
8GZU の概要
エントリーDOI | 10.2210/pdb8gzu/pdb |
EMDBエントリー | 34403 34404 34405 |
分子名称 | Transmembrane protein, putative, COXTT10, Ymf65, ... (164 entities in total) |
機能のキーワード | electron transport chain, supercomplex, membrane protein, tetrahymena thermophila, electron transport |
由来する生物種 | Tetrahymena thermophila SB210 詳細 |
タンパク質・核酸の鎖数 | 436 |
化学式量合計 | 11803642.70 |
構造登録者 | |
主引用文献 | Han, F.,Hu, Y.,Wu, M.,He, Z.,Tian, H.,Zhou, L. Structures of Tetrahymena thermophila respiratory megacomplexes on the tubular mitochondrial cristae. Nat Commun, 14:2542-2542, 2023 Cited by PubMed Abstract: Tetrahymena thermophila, a classic ciliate model organism, has been shown to possess tubular mitochondrial cristae and highly divergent electron transport chain involving four transmembrane protein complexes (I-IV). Here we report cryo-EM structures of its ~8 MDa megacomplex IV+ (I + III+ II), as well as a ~ 10.6 MDa megacomplex (IV + I + III+ II) at lower resolution. In megacomplex IV+ (I + III+ II), each CIV protomer associates one copy of supercomplex I + III and one copy of CII, forming a half ring-shaped architecture that adapts to the membrane curvature of mitochondrial cristae. Megacomplex (IV+ I + III+ II) defines the relative position between neighbouring half rings and maintains the proximity between CIV and CIII cytochrome c binding sites. Our findings expand the current understanding of divergence in eukaryotic electron transport chain organization and how it is related to mitochondrial morphology. PubMed: 37248254DOI: 10.1038/s41467-023-38158-5 主引用文献が同じPDBエントリー |
実験手法 | ELECTRON MICROSCOPY (4.18 Å) |
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