6QFG
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![BU of 6qfg by Molmil](/molmil-images/mine/6qfg) | Crystal Structure of Human Kallikrein 6 (I218Y) in complex with GSK144 | Descriptor: | 4-[(5-phenyl-1~{H}-imidazol-2-yl)methylamino]-2-(pyridin-3-ylmethoxy)benzenecarboximidamide, GLYCEROL, Kallikrein-6 | Authors: | Thorpe, J.H. | Deposit date: | 2019-01-10 | Release date: | 2019-05-08 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (1.68 Å) | Cite: | Evaluation of a crystallographic surrogate for kallikrein 5 in the discovery of novel inhibitors for Netherton syndrome. Acta Crystallogr.,Sect.F, 75, 2019
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7OLY
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![BU of 7oly by Molmil](/molmil-images/mine/7oly) | Structure of activin A in complex with an ActRIIB-Alk4 fusion reveal insight into activin receptor interactions | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-6)-alpha-D-mannopyranose-(1-6)-[alpha-D-mannopyranose-(1-3)]alpha-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Activin receptor type-1B, ... | Authors: | Hakansson, M, Rose, N.C, Castonguay, R, Logan, D.T, Krishnan, L. | Deposit date: | 2021-05-20 | Release date: | 2022-02-23 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (3.265 Å) | Cite: | Structures of activin ligand traps using natural sets of type I and type II TGF beta receptors. Iscience, 25, 2022
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6OJL
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![BU of 6ojl by Molmil](/molmil-images/mine/6ojl) | Structure of YePL2A R194K in Complex with Pentagalacturonic Acid | Descriptor: | 1,2-ETHANEDIOL, Periplasmic pectate lyase, alpha-D-galactopyranuronic acid-(1-4)-alpha-D-galactopyranuronic acid-(1-4)-alpha-D-galactopyranuronic acid-(1-4)-alpha-D-galactopyranuronic acid-(1-4)-beta-D-galactopyranuronic acid | Authors: | Jones, D.R, Abbott, D.W. | Deposit date: | 2019-04-11 | Release date: | 2019-11-20 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (1.5 Å) | Cite: | A surrogate structural platform informed by ancestral reconstruction and resurrection of a putative carbohydrate binding module hybrid illuminates the neofunctionalization of a pectate lyase. J.Struct.Biol., 207, 2019
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4RJV
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![BU of 4rjv by Molmil](/molmil-images/mine/4rjv) | Crystal Structure of a De Novo Designed Ferredoxin Fold, Northeast Structural Genomics Consortium (NESG) Target OR461 | Descriptor: | OR461 | Authors: | O'Connell, P.T, Lin, Y.-R, Guan, R, Koga, N, Koga, R, Seetharaman, J, Janjua, H, Xiao, R, Maglaqui, M, Everett, J.K, Acton, T.B, Baker, D, Montelione, G.T, Northeast Structural Genomics Consortium (NESG) | Deposit date: | 2014-10-09 | Release date: | 2014-10-22 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (1.523 Å) | Cite: | Northeast Structural Genomics Consortium Target OR461 To be published
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6LOO
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![BU of 6loo by Molmil](/molmil-images/mine/6loo) | Crystal Structure of Class IB terpene synthase bound with geranylcitronellyl diphosphate | Descriptor: | Tetraprenyl-beta-curcumene synthase, phosphono [(3~{R},6~{E},10~{E})-3,7,11,15-tetramethylhexadeca-6,10,14-trienyl] hydrogen phosphate, phosphono [(3~{S},6~{E},10~{E})-3,7,11,15-tetramethylhexadeca-6,10,14-trienyl] hydrogen phosphate | Authors: | Fujihashi, M, Inagi, H, Miki, K. | Deposit date: | 2020-01-07 | Release date: | 2020-11-18 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (1.99 Å) | Cite: | Characterization of Class IB Terpene Synthase: The First Crystal Structure Bound with a Substrate Surrogate. Acs Chem.Biol., 15, 2020
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5ABV
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6QFH
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![BU of 6qfh by Molmil](/molmil-images/mine/6qfh) | Crystal Structure of Human Kallikrein 6 (N217D/I218Y/K224R) in complex with GSK144. | Descriptor: | 4-[(5-phenyl-1~{H}-imidazol-2-yl)methylamino]-2-(pyridin-3-ylmethoxy)benzenecarboximidamide, GLYCEROL, Kallikrein-6 | Authors: | Thorpe, J.H. | Deposit date: | 2019-01-10 | Release date: | 2019-05-08 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (1.65 Å) | Cite: | Evaluation of a crystallographic surrogate for kallikrein 5 in the discovery of novel inhibitors for Netherton syndrome. Acta Crystallogr.,Sect.F, 75, 2019
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6QFE
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![BU of 6qfe by Molmil](/molmil-images/mine/6qfe) | Crystal Structure of Human Kallikrein 5 in complex with GSK144 | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 4-[(5-phenyl-1~{H}-imidazol-2-yl)methylamino]-2-(pyridin-3-ylmethoxy)benzenecarboximidamide, ... | Authors: | Thorpe, J.H. | Deposit date: | 2019-01-10 | Release date: | 2019-05-08 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (1.67 Å) | Cite: | Evaluation of a crystallographic surrogate for kallikrein 5 in the discovery of novel inhibitors for Netherton syndrome. Acta Crystallogr.,Sect.F, 75, 2019
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4J29
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![BU of 4j29 by Molmil](/molmil-images/mine/4j29) | Crystal Structure of Engineered Protein. Northeast Structural Genomics Consortium Target OR258. | Descriptor: | Engineered Protein OR258 | Authors: | Vorobiev, S, Su, M, Koga, R, Seetharaman, J, Koga, N, Mao, L, Xiao, R, Kohan, E, Castelllanos, J, Everett, J.K, Acton, T.B, Baker, D, Montelione, G.T, Tong, L, Hunt, J.F, Northeast Structural Genomics Consortium (NESG) | Deposit date: | 2013-02-04 | Release date: | 2013-03-13 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Crystal Structure of Engineered Protein OR258. To be Published
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3HC7
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8TID
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![BU of 8tid by Molmil](/molmil-images/mine/8tid) | Combined linker domain of N-DRC and associated proteins Tetrahymena | Descriptor: | AAA family ATPase CDC48 subfamily protein, CFAP20, Calmodulin 7-2, ... | Authors: | Ghanaeian, A.G, Majhi, S.M, McCaffrey, C.M, Nami, B.N, Black, C.B, Yang, S.K, Legal, T.L, Papoulas, O.P, Janowska, M.J, Valente-Paterno, M.V, Marcotte, E.M, Wloga, D.W, Bui, K.H. | Deposit date: | 2023-07-19 | Release date: | 2023-09-27 | Last modified: | 2024-04-03 | Method: | ELECTRON MICROSCOPY (3.6 Å) | Cite: | Integrated modeling of the Nexin-dynein regulatory complex reveals its regulatory mechanism. Nat Commun, 14, 2023
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7YKS
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![BU of 7yks by Molmil](/molmil-images/mine/7yks) | |
7YKR
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7QUC
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![BU of 7quc by Molmil](/molmil-images/mine/7quc) | D. melanogaster alpha/beta tubulin heterodimer in the GDP form | Descriptor: | GUANOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ... | Authors: | Wagstaff, J, Planelles-Herrero, V.J, Derivery, E, Lowe, J. | Deposit date: | 2022-01-17 | Release date: | 2022-09-21 | Last modified: | 2023-10-04 | Method: | ELECTRON MICROSCOPY (3.2 Å) | Cite: | Diverse cytomotive actins and tubulins share a polymerization switch mechanism conferring robust dynamics. Sci Adv, 9, 2023
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7QUD
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![BU of 7qud by Molmil](/molmil-images/mine/7qud) | D. melanogaster alpha/beta tubulin heterodimer in the GTP form | Descriptor: | GUANOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, Tubulin alpha-1 chain, ... | Authors: | Wagstaff, J, Planelles-Herrero, V.J, Derivery, E, Lowe, J. | Deposit date: | 2022-01-17 | Release date: | 2022-09-21 | Last modified: | 2023-10-04 | Method: | ELECTRON MICROSCOPY (3.47 Å) | Cite: | Diverse cytomotive actins and tubulins share a polymerization switch mechanism conferring robust dynamics. Sci Adv, 9, 2023
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7QUP
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![BU of 7qup by Molmil](/molmil-images/mine/7qup) | D. melanogaster 13-protofilament microtubule | Descriptor: | GUANOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ... | Authors: | Wagstaff, J, Planelles-Herrero, V.J, Derivery, E, Lowe, J. | Deposit date: | 2022-01-18 | Release date: | 2022-11-02 | Last modified: | 2023-10-04 | Method: | ELECTRON MICROSCOPY (3.8 Å) | Cite: | Diverse cytomotive actins and tubulins share a polymerization switch mechanism conferring robust dynamics. Sci Adv, 9, 2023
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8W78
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![BU of 8w78 by Molmil](/molmil-images/mine/8w78) | Structure of Drosophila melanogaster L-2-hydroxyglutarate dehydrogenase in complex with FAD and 2-oxoglutarate | Descriptor: | 2-OXOGLUTARIC ACID, DODECYL-BETA-D-MALTOSIDE, FI05204p, ... | Authors: | Yang, J, Chen, X, Jin, S, Ding, J. | Deposit date: | 2023-08-30 | Release date: | 2023-11-29 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (2.81 Å) | Cite: | Structure and biochemical characterization of l-2-hydroxyglutarate dehydrogenase and its role in the pathogenesis of l-2-hydroxyglutaric aciduria. J.Biol.Chem., 300, 2023
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8W75
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![BU of 8w75 by Molmil](/molmil-images/mine/8w75) | Structure of Drosophila melanogaster L-2-hydroxyglutarate dehydrogenase | Descriptor: | DODECYL-BETA-D-MALTOSIDE, FI05204p, FLAVIN-ADENINE DINUCLEOTIDE | Authors: | Yang, J, Chen, X, Jin, S, Ding, J. | Deposit date: | 2023-08-30 | Release date: | 2023-11-29 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (2.85 Å) | Cite: | Structure and biochemical characterization of l-2-hydroxyglutarate dehydrogenase and its role in the pathogenesis of l-2-hydroxyglutaric aciduria. J.Biol.Chem., 300, 2023
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8W7F
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![BU of 8w7f by Molmil](/molmil-images/mine/8w7f) | Structure of Drosophila melanogaster L-2-hydroxyglutarate dehydrogenase bound with FAD and a sulfate ion | Descriptor: | DODECYL-BETA-D-MALTOSIDE, FI05204p, FLAVIN-ADENINE DINUCLEOTIDE, ... | Authors: | Yang, J, Chen, X, Jin, S, Ding, J. | Deposit date: | 2023-08-30 | Release date: | 2023-11-29 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (2.299 Å) | Cite: | Structure and biochemical characterization of l-2-hydroxyglutarate dehydrogenase and its role in the pathogenesis of l-2-hydroxyglutaric aciduria. J.Biol.Chem., 300, 2023
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8ADK
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8ADJ
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![BU of 8adj by Molmil](/molmil-images/mine/8adj) | Poly(ADP-ribose) glycohydrolase (PARG) from Drosophila melanogaster in complex with PARG inhibitor PDD00017272 | Descriptor: | 1-[(2,5-dimethylpyrazol-3-yl)methyl]-N-(1-methylcyclopropyl)-3-[(2-methyl-1,3-thiazol-5-yl)methyl]-2,4-bis(oxidanylidene)quinazoline-6-sulfonamide, CHLORIDE ION, GLYCEROL, ... | Authors: | Ariza, A, Fontana, P. | Deposit date: | 2022-07-08 | Release date: | 2023-06-14 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (2.508 Å) | Cite: | Serine ADP-ribosylation in Drosophila provides insights into the evolution of reversible ADP-ribosylation signalling. Nat Commun, 14, 2023
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7RLO
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![BU of 7rlo by Molmil](/molmil-images/mine/7rlo) | Structure of the human eukaryotic translation initiation factor 2B (eIF2B) in complex with a viral protein NSs | Descriptor: | Non-structural protein NS-S, Translation initiation factor eIF-2B subunit alpha, Translation initiation factor eIF-2B subunit beta, ... | Authors: | Wang, L, Schoof, M, Cogan, J, Lawrence, R, Boone, M, Wuerth, J, Frost, M, Walter, P. | Deposit date: | 2021-07-26 | Release date: | 2021-12-22 | Last modified: | 2024-06-05 | Method: | ELECTRON MICROSCOPY (2.6 Å) | Cite: | Viral evasion of the integrated stress response through antagonism of eIF2-P binding to eIF2B. Nat Commun, 12, 2021
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8AU4
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![BU of 8au4 by Molmil](/molmil-images/mine/8au4) | Structural insights reveal a heterotetramer between oncogenic K-Ras4BG12V and Rgl2, a RalA/B activator | Descriptor: | Ral guanine nucleotide dissociation stimulator-like 2 | Authors: | Tariq, M, Ikeya, T, Togashi, N, Fairall, L, Alejo, C.B, Kamei, S, Alonso, B.R, Campillo, M.A.M, Hudson, A, Ito, Y, Schwabe, J, Dominguez, C, Tanaka, K. | Deposit date: | 2022-08-25 | Release date: | 2023-08-23 | Last modified: | 2023-10-25 | Method: | SOLUTION NMR | Cite: | Structural insights into the complex of oncogenic KRas4B G12V and Rgl2, a RalA/B activator. Life Sci Alliance, 7, 2024
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7AMP
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![BU of 7amp by Molmil](/molmil-images/mine/7amp) | Crystal structure of the complex of HuJovi-1 Fab with the human A6 T-cell receptor TRBC1 | Descriptor: | Alpha chain of A6 T-cell receptor, Beta chain 1 of A6 T-cell receptor TRBC1, CHLORIDE ION, ... | Authors: | Ferrari, M, Bulek, A, Bughda, R, Jha, R, Welin, M, Logan, D.T, Sewell, A, Onuoha, S, Pule, M. | Deposit date: | 2020-10-09 | Release date: | 2022-04-20 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (2.64 Å) | Cite: | Structure-Guided Engineering of Immunotherapies Targeting TRBC1 and TRBC2 in T Cell Malignancies Res Sq, 2022
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7AMQ
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![BU of 7amq by Molmil](/molmil-images/mine/7amq) | Crystal structure of the complex of HuJovi-1 Fab with the human TRBC2 | Descriptor: | CHLORIDE ION, GLYCEROL, Human A6 T-cell receptor alpha chain, ... | Authors: | Ferrari, M, Bulek, A, Bughda, R, Jha, R, Welin, M, Logan, D.T, Sewell, A, Onuoha, S, Pule, M. | Deposit date: | 2020-10-09 | Release date: | 2022-04-20 | Last modified: | 2022-04-27 | Method: | X-RAY DIFFRACTION (2.353 Å) | Cite: | Structure-Guided Engineering of Immunotherapies Targeting TRBC1 and TRBC2 in T Cell Malignancies Res Sq, 2022
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