7RLO

Structure of the human eukaryotic translation initiation factor 2B (eIF2B) in complex with a viral protein NSs

Summary for 7RLO

Entry DOI	10.2210/pdb7rlo/pdb
EMDB information	24535
Descriptor	Translation initiation factor eIF-2B subunit epsilon, Translation initiation factor eIF-2B subunit beta, Translation initiation factor eIF-2B subunit delta, ... (6 entities in total)
Functional Keywords	complex, viral protein, integrated stress response, protein translation, translation
Biological source	Homo sapiens (Human) More
Total number of polymer chains	12
Total formula weight	583746.17
Authors	Wang, L.,Schoof, M.,Cogan, J.,Lawrence, R.,Boone, M.,Wuerth, J.,Frost, M.,Walter, P. (deposition date: 2021-07-26, release date: 2021-12-22)
Primary citation	Schoof, M.,Wang, L.,Cogan, J.Z.,Lawrence, R.E.,Boone, M.,Wuerth, J.D.,Frost, A.,Walter, P. Viral evasion of the integrated stress response through antagonism of eIF2-P binding to eIF2B. Nat Commun, 12:7103-7103, 2021 Cited by PubMed: 34876554 DOI: 10.1038/s41467-021-26164-4 PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (2.6 Å)

Structure validation