7RLO

Structure of the human eukaryotic translation initiation factor 2B (eIF2B) in complex with a viral protein NSs

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	Translation initiation factor eIF-2B subunit epsilon	polymer	721	80466.6	2	UniProt (Q13144) Pfam (PF02020)	Homo sapiens (Human)	eIF-2B GDP-GTP exchange factor subunit epsilon
2	C, D (C, D)	Translation initiation factor eIF-2B subunit beta	polymer	351	39039.5	2	UniProt (P49770) Pfam (PF01008)	Homo sapiens (Human)	S20I15,S20III15,eIF-2B GDP-GTP exchange factor subunit beta
3	E, F (E, F)	Translation initiation factor eIF-2B subunit delta	polymer	523	57640.2	2	UniProt (Q9UI10) Pfam (PF01008)	Homo sapiens (Human)	eIF-2B GDP-GTP exchange factor subunit delta
4	G, H (G, H)	Translation initiation factor eIF-2B subunit alpha	polymer	305	33754.1	2	UniProt (Q14232) Pfam (PF01008)	Homo sapiens (Human)	eIF-2B GDP-GTP exchange factor subunit alpha
5	I, J (I, J)	Translation initiation factor eIF-2B subunit gamma	polymer	452	50304.2	2	UniProt (Q9NR50) Pfam (PF00483)	Homo sapiens (Human)	eIF-2B GDP-GTP exchange factor subunit gamma
6	K, L (K, L)	Non-structural protein NS-S	polymer	269	30668.4	2	UniProt (P12792) Pfam (PF11073)	Sandfly fever sicilian virus (SFS)

Sequence modifications

K, L: 1 - 261 (UniProt: P12792)

PDB	External Database	Details
Gly 262	-	expression tag
Ser 263	-	expression tag
His 264	-	expression tag
His 265	-	expression tag
His 266	-	expression tag
His 267	-	expression tag
His 268	-	expression tag
His 269	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	12
	Total formula weight	583746.2
All*	Total formula weight	583746.2

*Water molecules are not included.