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6QFG

Crystal Structure of Human Kallikrein 6 (I218Y) in complex with GSK144

Summary for 6QFG
Entry DOI10.2210/pdb6qfg/pdb
Related6QFE 6QFF
DescriptorKallikrein-6, GLYCEROL, 4-[(5-phenyl-1~{H}-imidazol-2-yl)methylamino]-2-(pyridin-3-ylmethoxy)benzenecarboximidamide, ... (4 entities in total)
Functional Keywordsprotease, inhibitor, complex, hydrolase
Biological sourceHomo sapiens (Human)
Total number of polymer chains2
Total formula weight49916.53
Authors
Thorpe, J.H. (deposition date: 2019-01-10, release date: 2019-05-08, Last modification date: 2024-01-24)
Primary citationThorpe, J.H.,Edgar, E.V.,Smith, K.J.,Lewell, X.Q.,Rella, M.,White, G.V.,Polyakova, O.,Nassau, P.,Walker, A.L.,Holmes, D.S.,Pearce, A.C.,Wang, Y.,Liddle, J.,Hovnanian, A.
Evaluation of a crystallographic surrogate for kallikrein 5 in the discovery of novel inhibitors for Netherton syndrome.
Acta Crystallogr.,Sect.F, 75:385-391, 2019
Cited by
PubMed: 31045568
DOI: 10.1107/S2053230X19003169
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.68 Å)
Structure validation

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