6QFH
Crystal Structure of Human Kallikrein 6 (N217D/I218Y/K224R) in complex with GSK144.
Summary for 6QFH
Entry DOI | 10.2210/pdb6qfh/pdb |
Descriptor | Kallikrein-6, 4-[(5-phenyl-1~{H}-imidazol-2-yl)methylamino]-2-(pyridin-3-ylmethoxy)benzenecarboximidamide, GLYCEROL, ... (4 entities in total) |
Functional Keywords | protease, inhibitor, complex, hydrolase |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 2 |
Total formula weight | 49716.17 |
Authors | Thorpe, J.H. (deposition date: 2019-01-10, release date: 2019-05-08, Last modification date: 2024-01-24) |
Primary citation | Thorpe, J.H.,Edgar, E.V.,Smith, K.J.,Lewell, X.Q.,Rella, M.,White, G.V.,Polyakova, O.,Nassau, P.,Walker, A.L.,Holmes, D.S.,Pearce, A.C.,Wang, Y.,Liddle, J.,Hovnanian, A. Evaluation of a crystallographic surrogate for kallikrein 5 in the discovery of novel inhibitors for Netherton syndrome. Acta Crystallogr.,Sect.F, 75:385-391, 2019 Cited by PubMed: 31045568DOI: 10.1107/S2053230X19003169 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.65 Å) |
Structure validation
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