6QFH
Crystal Structure of Human Kallikrein 6 (N217D/I218Y/K224R) in complex with GSK144.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Kallikrein-6 | polymer | 222 | 24367.5 | 2 | UniProt (Q92876) Pfam (PF00089) | Homo sapiens (Human) | Neurosin,Protease M,SP59,Serine protease 18,Serine protease 9,Zyme |
| 2 | C, F (A, B) | 4-[(5-phenyl-1~{H}-imidazol-2-yl)methylamino]-2-(pyridin-3-ylmethoxy)benzenecarboximidamide | non-polymer | 398.5 | 2 | Chemie (J08) | |||
| 3 | D, E (B) | GLYCEROL | non-polymer | 92.1 | 2 | Chemie (GOL) | |||
| 4 | G, H (A, B) | water | water | 18.0 | 296 | Chemie (HOH) |
Sequence modifications
A, B: 16 - 244 (UniProt: Q92876)
| PDB | External Database | Details |
|---|---|---|
| Gly 74 | Arg 78 | conflict |
| Gln 76 | Arg 80 | conflict |
| Gln 132 | Asn 134 | conflict |
| Asp 217 | Asn 215 | engineered mutation |
| Tyr 218 | Ile 216 | engineered mutation |
| Arg 224 | Lys 223 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 48735.1 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 981.1 | |
| All* | Total formula weight | 49716.2 |
