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5G53
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BU of 5g53 by Molmil
Structure of the adenosine A2A receptor bound to an engineered G protein
Descriptor: ADENOSINE RECEPTOR A2A, ENGINEERED DOMAIN OF HUMAN G ALPHA S LONG ISOFORM, GUANOSINE-5'-DIPHOSPHATE, ...
Authors:Carpenter, B, Nehme, R, Warne, T, Leslie, A.G.W, Tate, C.G.
Deposit date:2016-05-19
Release date:2016-08-03
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (3.4 Å)
Cite:Structure of the Adenosine A2A Receptor Bound to an Engineered G Protein
Nature, 536, 2016
7W7E
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BU of 7w7e by Molmil
Cryo-EM structure of the alpha2A adrenergic receptor GoA signaling complex bound to a biased agonist
Descriptor: 5-(3-bicyclo[4.2.0]octa-1,3,5-trienyl)-1,2,3,6-tetrahydropyridine, Alpha-2A adrenergic receptor, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ...
Authors:Xu, J, Fink, E.A, Shoichet, B.K, Du, Y.
Deposit date:2021-12-04
Release date:2022-09-28
Last modified:2022-10-12
Method:ELECTRON MICROSCOPY (3.4 Å)
Cite:Structure-based discovery of nonopioid analgesics acting through the alpha 2A -adrenergic receptor.
Science, 377, 2022
6WH4
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BU of 6wh4 by Molmil
Crystal structure of HTR2A with inverse agonist
Descriptor: 1-methyl-4-[(5~{S})-3-methylsulfanyl-5,6-dihydrobenzo[b][1]benzothiepin-5-yl]piperazine, 5-hydroxytryptamine receptor 2A,Soluble cytochrome b562 fusion, CHOLESTEROL, ...
Authors:Kim, K.L, Che, T, Krumm, B.E, Roth, B.L.
Deposit date:2020-04-07
Release date:2020-09-23
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (3.4 Å)
Cite:Structure of a Hallucinogen-Activated Gq-Coupled 5-HT 2A Serotonin Receptor
Cell(Cambridge,Mass.), 182, 2020
7YU3
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BU of 7yu3 by Molmil
Human Lysophosphatidic Acid Receptor 1-Gi complex bound to ONO-0740556
Descriptor: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(i) subunit alpha-1, ...
Authors:Akasaka, H, Shihoya, W, Nureki, O.
Deposit date:2022-08-16
Release date:2022-10-05
Method:ELECTRON MICROSCOPY (3.4 Å)
Cite:Structure of the active G i -coupled human lysophosphatidic acid receptor 1 complexed with a potent agonist.
Nat Commun, 13, 2022
8GGU
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BU of 8ggu by Molmil
Locally refined cryoEM structure of receptor from beta-2-adrenergic receptor in complex with GTP-bound Gs heterotrimer (transition intermediate #13 of 20)
Descriptor: (5R,6R)-6-(methylamino)-5,6,7,8-tetrahydronaphthalene-1,2,5-triol, Beta-2 adrenergic receptor
Authors:Papasergi-Scott, M.M, Skiniotis, G.
Deposit date:2023-03-08
Release date:2024-03-06
Last modified:2024-06-05
Method:ELECTRON MICROSCOPY (3.4 Å)
Cite:Time-resolved cryo-EM of G-protein activation by a GPCR.
Nature, 629, 2024
6WGT
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BU of 6wgt by Molmil
Crystal structure of HTR2A with hallucinogenic agonist
Descriptor: (8alpha)-N,N-diethyl-6-methyl-9,10-didehydroergoline-8-carboxamide, 5-hydroxytryptamine receptor 2A,Soluble cytochrome b562 fusion, CHOLESTEROL, ...
Authors:Kim, K.L, Che, T, Krumm, B.E, Roth, B.L.
Deposit date:2020-04-06
Release date:2020-09-23
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (3.4 Å)
Cite:Structure of a Hallucinogen-Activated Gq-Coupled 5-HT 2A Serotonin Receptor
Cell(Cambridge,Mass.), 182, 2020
7C6A
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BU of 7c6a by Molmil
Crystal structure of AT2R-BRIL and SRP2070_Fab complex
Descriptor: IgG Light Chain, IgG heavy chain, SAR1, ...
Authors:Suzuki, M, Miyagi, H, Asada, H, Yasunaga, M, Suno, C, Takahashi, Y, Saito, J, Iwata, S.
Deposit date:2020-05-21
Release date:2020-07-29
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (3.4 Å)
Cite:The discovery of a new antibody for BRIL-fused GPCR structure determination.
Sci Rep, 10, 2020
7EXD
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BU of 7exd by Molmil
Lasmiditan-bound serotonin 1F (5-HT1F) receptor-Gi protein complex
Descriptor: 2,4,6-tris(fluoranyl)-N-[6-(1-methylpiperidin-4-yl)carbonylpyridin-2-yl]benzamide, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ...
Authors:Huang, S, Xu, P, Jiang, Y, Xu, H.E.
Deposit date:2021-05-27
Release date:2021-08-04
Last modified:2021-10-06
Method:ELECTRON MICROSCOPY (3.4 Å)
Cite:Structural basis for recognition of anti-migraine drug lasmiditan by the serotonin receptor 5-HT 1F -G protein complex.
Cell Res., 31, 2021
8IQ6
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BU of 8iq6 by Molmil
Cryo-EM structure of Latanoprost-bound prostaglandin-F2-alpha receptor-miniGq-Nb35 complex
Descriptor: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(s) subunit alpha isoforms short, ...
Authors:Lv, X, Gao, K, Nie, J, Zhang, X, Zhang, S, Ren, Y, Li, Q, Huang, J, Liu, L, Zhang, X, Sun, X, Zhang, W, Liu, X.
Deposit date:2023-03-15
Release date:2024-01-31
Method:ELECTRON MICROSCOPY (3.4 Å)
Cite:Structures of human prostaglandin F 2 alpha receptor reveal the mechanism of ligand and G protein selectivity.
Nat Commun, 14, 2023
8X64
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BU of 8x64 by Molmil
CryoEM structure of the histamine H1 receptor-BRIL/Anti BRIL Fab complex with desloratadine
Descriptor: Histamine H1 receptor,Soluble cytochrome b562, desloratadine
Authors:Wang, D.D, Guo, Q.
Deposit date:2023-11-20
Release date:2024-01-17
Method:ELECTRON MICROSCOPY (3.4 Å)
Cite:Molecular mechanism of antihistamines recognition and regulation of the histamine H 1 receptor.
Nat Commun, 15, 2024
8IKG
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BU of 8ikg by Molmil
Cryo-EM structure of human receptor with G proteins
Descriptor: 3-[(1S)-1-(furan-2-yl)-2-nitro-ethyl]-2-phenyl-1H-indole, Cannabinoid receptor 1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ...
Authors:Shen, S.Y, Shao, Z.H.
Deposit date:2023-02-28
Release date:2024-06-05
Method:ELECTRON MICROSCOPY (3.4 Å)
Cite:Cryo-EM structure of human receptor with G proteins
To Be Published
7X9B
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BU of 7x9b by Molmil
Cryo-EM structure of neuropeptide Y Y2 receptor in complex with NPY and Gi
Descriptor: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(i) subunit alpha-1, ...
Authors:Tang, T, Han, S, Zhao, Q, Wu, B.
Deposit date:2022-03-15
Release date:2022-05-18
Method:ELECTRON MICROSCOPY (3.4 Å)
Cite:Receptor-specific recognition of NPY peptides revealed by structures of NPY receptors.
Sci Adv, 8, 2022
7XBX
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BU of 7xbx by Molmil
Cryo-EM structure of the human chemokine receptor CX3CR1 in complex with CX3CL1 and Gi1
Descriptor: CHOLESTEROL, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ...
Authors:Lu, M, Zhao, W, Han, S, Zhu, Y, Wu, B, Zhao, Q.
Deposit date:2022-03-22
Release date:2022-07-13
Method:ELECTRON MICROSCOPY (3.4 Å)
Cite:Activation of the human chemokine receptor CX3CR1 regulated by cholesterol.
Sci Adv, 8, 2022
3C9M
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BU of 3c9m by Molmil
Structure of a mutant bovine rhodopsin in hexagonal crystal form
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, ACETYL GROUP, RETINAL, ...
Authors:Stenkamp, R.E.
Deposit date:2008-02-16
Release date:2008-08-05
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (3.4 Å)
Cite:Alternative models for two crystal structures of bovine rhodopsin.
Acta Crystallogr.,Sect.D, 64, 2008
3KJ6
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BU of 3kj6 by Molmil
Crystal structure of a Methylated beta2 Adrenergic Receptor-Fab complex
Descriptor: Beta-2 adrenergic receptor, Fab heavy chain, Fab light chain, ...
Authors:Bokoch, M.P, Zou, Y, Rasmussen, S.G.F, Liu, C.W, Nygaard, R, Rosenbaum, D.M, Fung, J.J, Choi, H.-J, Thian, F.S, Kobilka, T.S, Puglisi, J.D, Weis, W.I, Pardo, L, Prosser, S, Mueller, L, Kobilka, B.K.
Deposit date:2009-11-02
Release date:2010-02-16
Last modified:2021-10-13
Method:X-RAY DIFFRACTION (3.4 Å)
Cite:Ligand-specific regulation of the extracellular surface of a G-protein-coupled receptor.
Nature, 463, 2010
2R4S
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BU of 2r4s by Molmil
Crystal structure of the human beta2 adrenoceptor
Descriptor: Beta-2 adrenergic receptor, antibody for beta2 adrenoceptor, heavy chain, ...
Authors:Rasmussen, S.G.F, Choi, H.J, Rosenbaum, D.M, Kobilka, T.S, Thian, F.S, Edwards, P.C, Burghammer, M, Ratnala, V.R, Sanishvili, R, Fischetti, R.F, Schertler, G.F, Weis, W.I, Kobilka, B.K.
Deposit date:2007-08-31
Release date:2007-11-06
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (3.4 Å)
Cite:Crystal structure of the human beta2 adrenergic G-protein-coupled receptor.
Nature, 450, 2007
8IC0
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BU of 8ic0 by Molmil
Cryo-EM structure of CXCL8 bound C-X-C chemokine receptor 1 in complex with Gi heterotrimer
Descriptor: C-X-C chemokine receptor type 1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ...
Authors:Ishimoto, N, Park, J.H, Park, S.Y.
Deposit date:2023-02-10
Release date:2023-07-19
Method:ELECTRON MICROSCOPY (3.41 Å)
Cite:Structural basis of CXC chemokine receptor 1 ligand binding and activation.
Nat Commun, 14, 2023
7EW0
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BU of 7ew0 by Molmil
Cryo-EM structure of ozanimod -bound Sphingosine-1-phosphate receptor 1 in complex with Gi protein
Descriptor: 5-[3-[(1~{S})-1-(2-hydroxyethylamino)-2,3-dihydro-1~{H}-inden-4-yl]-1,2,4-oxadiazol-5-yl]-2-propan-2-yloxy-benzenecarbonitrile, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ...
Authors:Yuan, Y, Jia, G.W, Su, Z.M, Shao, Z.H.
Deposit date:2021-05-24
Release date:2021-09-29
Last modified:2022-02-16
Method:ELECTRON MICROSCOPY (3.42 Å)
Cite:Structures of signaling complexes of lipid receptors S1PR1 and S1PR5 reveal mechanisms of activation and drug recognition.
Cell Res., 31, 2021
8XBG
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BU of 8xbg by Molmil
Human GPR34 -Gi complex bound to S3E-LysoPS, receptor focused
Descriptor: (2~{S})-2-azanyl-3-[[(2~{R})-1-ethoxy-3-[(~{Z})-octadec-9-enoyl]oxy-propan-2-yl]oxy-oxidanyl-phosphoryl]oxy-propanoic acid, Probable G-protein coupled receptor 34
Authors:Kawahara, R, Shihoya, W, Nureki, O.
Deposit date:2023-12-06
Release date:2024-05-15
Method:ELECTRON MICROSCOPY (3.43 Å)
Cite:Structural basis for lysophosphatidylserine recognition by GPR34.
Nat Commun, 15, 2024
8K5B
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BU of 8k5b by Molmil
Cryo-EM structure of niacin bound human hydroxy-carboxylic acid receptor 2 (Local refinement)
Descriptor: Human Hydroxycarboxylic acid receptor 2, NICOTINIC ACID
Authors:Park, J.H, Ishimoto, N, Park, S.Y.
Deposit date:2023-07-21
Release date:2023-11-22
Last modified:2024-05-08
Method:ELECTRON MICROSCOPY (3.43 Å)
Cite:Structural basis for ligand recognition and signaling of hydroxy-carboxylic acid receptor 2.
Nat Commun, 14, 2023
7RAN
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BU of 7ran by Molmil
5-HT2AR bound to a novel agonist in complex with a mini-Gq protein and an active-state stabilizing single-chain variable fragment (scFv16) obtained by cryo-electron microscopy (cryoEM)
Descriptor: (3R)-3-methyl-5-(1H-pyrrolo[2,3-b]pyridin-3-yl)-1,2,3,6-tetrahydropyridin-1-ium, 5-hydroxytryptamine receptor 2A, G protein subunit q (Gi2-mini-Gq chimera), ...
Authors:Barros-Alvarez, X, Kim, K, Panova, O, Roth, B.L, Skiniotis, G.
Deposit date:2021-07-02
Release date:2022-07-06
Last modified:2022-11-02
Method:ELECTRON MICROSCOPY (3.45 Å)
Cite:Bespoke library docking for 5-HT 2A receptor agonists with antidepressant activity.
Nature, 610, 2022
8IYW
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BU of 8iyw by Molmil
Structure of GSK256073-GPR109A-G-protein complex
Descriptor: 8-chloranyl-3-pentyl-7H-purine-2,6-dione, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ...
Authors:Yadav, M.K, Sarma, P, Chami, M, Banerjee, R, Shukla, A.K.
Deposit date:2023-04-06
Release date:2024-03-06
Last modified:2024-03-20
Method:ELECTRON MICROSCOPY (3.45 Å)
Cite:Structure-guided engineering of biased-agonism in the human niacin receptor via single amino acid substitution.
Nat Commun, 15, 2024
8JER
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BU of 8jer by Molmil
Structure of Acipimox-GPR109A-G protein complex
Descriptor: 5-methyl-4-oxidanyl-pyrazin-4-ium-2-carboxylic acid, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ...
Authors:Yadav, M.K, Sarma, P, Chami, M, Banerjee, R, Shukla, A.K.
Deposit date:2023-05-16
Release date:2024-03-06
Last modified:2024-03-20
Method:ELECTRON MICROSCOPY (3.45 Å)
Cite:Structure-guided engineering of biased-agonism in the human niacin receptor via single amino acid substitution.
Nat Commun, 15, 2024
8A2O
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BU of 8a2o by Molmil
Room-temperature structure of the stabilised A2A-Theophylline complex determined by synchrotron serial crystallography
Descriptor: (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, Adenosine receptor A2a,Soluble cytochrome b562, CHOLESTEROL, ...
Authors:Moraes, I, Kwan, T.O.C, Axford, D.
Deposit date:2022-06-06
Release date:2023-08-30
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (3.45 Å)
Cite:A versatile approach to high-density microcrystals in lipidic cubic phase for room-temperature serial crystallography.
J.Appl.Crystallogr., 56, 2023
7VH0
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BU of 7vh0 by Molmil
MT2-remalteon-Gi complex
Descriptor: Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(i) subunit alpha-1, Melatonin receptor type 1B, ...
Authors:Wang, Q.G, Lu, Q.Y.
Deposit date:2021-09-20
Release date:2022-03-02
Last modified:2022-09-14
Method:ELECTRON MICROSCOPY (3.46 Å)
Cite:Structural basis of the ligand binding and signaling mechanism of melatonin receptors.
Nat Commun, 13, 2022

222036

건을2024-07-03부터공개중

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