5FB6
 
 | | Room-temperature macromolecular crystallography using a micro-patterned silicon chip with minimal background scattering | | Descriptor: | Insulin Chain A, Insulin Chain B | | Authors: | Roedig, P, Duman, R, Sanchez-Weatherby, J, Vartiainen, I, Burkhardt, A, Warmer, M, David, C, Wagner, A, Meents, A. | | Deposit date: | 2015-12-14 | | Release date: | 2016-06-15 | | Last modified: | 2024-01-10 | | Method: | X-RAY DIFFRACTION (1.901 Å) | | Cite: | Room-temperature macromolecular crystallography using a micro-patterned silicon chip with minimal background scattering.
J.Appl.Crystallogr., 49, 2016
|
|
8ONI
 | | Human insulin in complex with the analytical antibody S1 Fab | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Heavy chain of analytical antibody S1 Fab, Insulin A chain, ... | | Authors: | Johansson, E. | | Deposit date: | 2023-04-03 | | Release date: | 2024-04-10 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | Macromolecular structure of insulin and IgE clonality impacts IgE-mediated activation of sensitized basophils
To Be Published
|
|
8ONK
 | |
3Q6E
 | | Human insulin in complex with cucurbit[7]uril | | Descriptor: | Insulin A chain, Insulin B chain, cucurbit[7]uril | | Authors: | Chinai, J.M, Taylor, A.B, Hargreaves, N.D, Ryno, L.M, Morris, C.A, Hart, P.J, Urbach, A.R. | | Deposit date: | 2010-12-31 | | Release date: | 2011-04-20 | | Last modified: | 2023-09-13 | | Method: | X-RAY DIFFRACTION (2.05 Å) | | Cite: | Molecular recognition of insulin by a synthetic receptor.
J.Am.Chem.Soc., 133, 2011
|
|
3RTO
 | | Acoustically mounted porcine insulin microcrystals yield an X-ray SAD structure | | Descriptor: | Insulin, ZINC ION | | Authors: | Soares, A.S, Engel, M.A, Stearns, R, Datwani, S, Olechno, J, Ellson, R, Skinner, J.M, Allaire, M, Orville, A.M. | | Deposit date: | 2011-05-03 | | Release date: | 2011-05-18 | | Last modified: | 2023-09-13 | | Method: | X-RAY DIFFRACTION (1.8 Å) | | Cite: | Acoustically Mounted Microcrystals Yield High-Resolution X-ray Structures.
Biochemistry, 50, 2011
|
|
6H3M
 | |
5MIZ
 | |
5MHD
 | |
5MAM
 | | Human insulin in complex with serotonin | | Descriptor: | CHLORIDE ION, Insulin A chain, Insulin B chain, ... | | Authors: | Brzozowski, A.M, Turkenburg, J.P, Jiracek, J, Zakova, L. | | Deposit date: | 2016-11-03 | | Release date: | 2017-04-05 | | Last modified: | 2017-05-31 | | Method: | X-RAY DIFFRACTION (2.2 Å) | | Cite: | Computational and structural evidence for neurotransmitter-mediated modulation of the oligomeric states of human insulin in storage granules.
J. Biol. Chem., 292, 2017
|
|
5MWQ
 | |
5MT9
 | | Human insulin in complex with serotonin and arginine | | Descriptor: | ARGININE, CHLORIDE ION, Insulin, ... | | Authors: | Brzozowski, A.M, Turkenburg, J.P, Jiracek, J, Zakova, L. | | Deposit date: | 2017-01-07 | | Release date: | 2017-04-05 | | Last modified: | 2024-01-17 | | Method: | X-RAY DIFFRACTION (1.88 Å) | | Cite: | Computational and structural evidence for neurotransmitter-mediated modulation of the oligomeric states of human insulin in storage granules.
J. Biol. Chem., 292, 2017
|
|
5MT3
 | | Human insulin in complex with serotonin and arginine | | Descriptor: | ARGININE, CHLORIDE ION, Insulin, ... | | Authors: | Brzozowski, A.M, Turkenburg, J.P, Jiracek, J, Zakova, L. | | Deposit date: | 2017-01-06 | | Release date: | 2017-04-05 | | Last modified: | 2024-01-17 | | Method: | X-RAY DIFFRACTION (2.02 Å) | | Cite: | Computational and structural evidence for neurotransmitter-mediated modulation of the oligomeric states of human insulin in storage granules.
J. Biol. Chem., 292, 2017
|
|
6INS
 | | X-RAY ANALYSIS OF THE SINGLE CHAIN B29-A1 PEPTIDE-LINKED INSULIN MOLECULE. A COMPLETELY INACTIVE ANALOGUE | | Descriptor: | INSULIN, ZINC ION | | Authors: | Derewenda, U, Derewenda, Z, Dodson, E.J, Dodson, G.G, Bing, X, Markussen, J. | | Deposit date: | 1992-11-25 | | Release date: | 1994-01-31 | | Last modified: | 2024-06-05 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | X-ray analysis of the single chain B29-A1 peptide-linked insulin molecule. A completely inactive analogue.
J.Mol.Biol., 220, 1991
|
|
6TYH
 | | Four-Disulfide Insulin Analog A22/B22 | | Descriptor: | ACETONE, CHLORIDE ION, GLYCEROL, ... | | Authors: | Blakely, A.D, Xiong, X. | | Deposit date: | 2019-08-08 | | Release date: | 2019-11-13 | | Last modified: | 2020-03-11 | | Method: | X-RAY DIFFRACTION (1.600019 Å) | | Cite: | Novel four-disulfide insulin analog with high aggregation stability and potency.
Chem Sci, 11, 2020
|
|
6JR3
 | |
6U46
 | |
6GV0
 | | Insulin glulisine | | Descriptor: | FORMIC ACID, Insulin, ZINC ION | | Authors: | Chayen, N.E, Helliwell, J.R, Solomon-Gamsu, H.V, Govada, L, Morgan, M, Gillis, R.B, Adams, G. | | Deposit date: | 2018-06-20 | | Release date: | 2019-07-03 | | Last modified: | 2024-01-17 | | Method: | X-RAY DIFFRACTION (1.26 Å) | | Cite: | Analysis of insulin glulisine at the molecular level by X-ray crystallography and biophysical techniques.
Sci Rep, 11, 2021
|
|
1LPH
 | | LYS(B28)PRO(B29)-HUMAN INSULIN | | Descriptor: | CHLORIDE ION, INSULIN, PHENOL, ... | | Authors: | Ciszak, E, Beals, J.M, Frank, B.H, Baker, J.C, Carter, N.D, Smith, G.D. | | Deposit date: | 1995-04-19 | | Release date: | 1996-06-20 | | Last modified: | 2021-11-03 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | Role of C-terminal B-chain residues in insulin assembly: the structure of hexameric LysB28ProB29-human insulin.
Structure, 3, 1995
|
|
1M5A
 | |
2WS1
 | | Semi-synthetic analogue of human insulin NMeTyrB26-insulin in monomer form | | Descriptor: | ACETATE ION, INSULIN A CHAIN, INSULIN B CHAIN | | Authors: | Brzozowski, A.M, Jiracek, J, Zakova, L, Antolikova, E, Watson, C.J, Turkenburg, J.P, Dodson, G.G. | | Deposit date: | 2009-09-03 | | Release date: | 2010-02-09 | | Last modified: | 2023-12-20 | | Method: | X-RAY DIFFRACTION (1.6 Å) | | Cite: | Implications for the Active Form of Human Insulin Based on the Structural Convergence of Highly Active Hormone Analogues.
Proc.Natl.Acad.Sci.USA, 107, 2010
|
|
1MHI
 | | THREE-DIMENSIONAL SOLUTION STRUCTURE OF AN INSULIN DIMER. A STUDY OF THE B9(ASP) MUTANT OF HUMAN INSULIN USING NUCLEAR MAGNETIC RESONANCE DISTANCE GEOMETRY AND RESTRAINED MOLECULAR DYNAMICS | | Descriptor: | INSULIN | | Authors: | Jorgensen, A.M.M, Kristensen, S.M, Led, J.J, Balschmidt, P. | | Deposit date: | 1994-11-30 | | Release date: | 1995-10-15 | | Last modified: | 2017-11-29 | | Method: | SOLUTION NMR | | Cite: | Three-dimensional solution structure of an insulin dimer. A study of the B9(Asp) mutant of human insulin using nuclear magnetic resonance, distance geometry and restrained molecular dynamics.
J.Mol.Biol., 227, 1992
|
|
1MHJ
 | |
2WS0
 | | Semi-synthetic analogue of human insulin NMeAlaB26-insulin at pH 7.5 | | Descriptor: | INSULIN A CHAIN, INSULIN B CHAIN | | Authors: | Brzozowski, A.M, Jiracek, J, Zakova, L, Antolikova, E, Watson, C.J, Turkenburg, J.P, Dodson, G.G. | | Deposit date: | 2009-09-03 | | Release date: | 2010-02-09 | | Last modified: | 2023-12-20 | | Method: | X-RAY DIFFRACTION (2.1 Å) | | Cite: | Implications for the Active Form of Human Insulin Based on the Structural Convergence of Highly Active Hormone Analogues.
Proc.Natl.Acad.Sci.USA, 107, 2010
|
|
8SBD
 | | Cryo-EM structure of insulin amyloid-like fibril that is composed of two antiparallel protofilaments | | Descriptor: | Insulin A chain, Insulin B chain | | Authors: | Wang, L.W, Hall, C, Uchikawa, E, Chen, D.L, Choi, E, Zhang, X.W, Bai, X.C. | | Deposit date: | 2023-04-03 | | Release date: | 2023-08-30 | | Last modified: | 2023-09-27 | | Method: | ELECTRON MICROSCOPY (3.2 Å) | | Cite: | Structural basis of insulin fibrillation.
Sci Adv, 9, 2023
|
|
2W44
 | | Structure DeltaA1-A4 insulin | | Descriptor: | CHLORIDE ION, INSULIN, RESORCINOL, ... | | Authors: | Thorsoee, K.S, Schlein, M, Brandt, J, Schluckebier, G, Naver, H. | | Deposit date: | 2008-11-21 | | Release date: | 2009-12-22 | | Last modified: | 2023-12-13 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Kinetic Evidence for the Sequential Association of Insulin Binding Sites 1 and 2 to the Insulin Receptor and the Influence of Receptor Isoform.
Biochemistry, 49, 2010
|
|
