8FPT
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![BU of 8fpt by Molmil](/molmil-images/mine/8fpt) | STRUCTURE OF ALPHA-SYNUCLEIN FIBRILS DERIVED FROM HUMAN LEWY BODY DEMENTIA TISSUE | Descriptor: | Alpha-synuclein | Authors: | Barclay, A.M, Dhavale, D.D, Borcik, C.G, Rau, M.J, Basore, K, Milchberg, M.H, Warmuth, O.A, Kotzbauer, P.T, Rienstra, C.M, Schwieters, C.D. | Deposit date: | 2023-01-05 | Release date: | 2023-02-22 | Last modified: | 2024-05-15 | Method: | SOLID-STATE NMR | Cite: | Structure of alpha-synuclein fibrils derived from human Lewy body dementia tissue. Biorxiv, 2023
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6LOJ
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![BU of 6loj by Molmil](/molmil-images/mine/6loj) | The complex structure of IpaH9.8-LRR and hGBP1 | Descriptor: | GUANOSINE-5'-DIPHOSPHATE, Guanylate-binding protein 1, Invasion plasmid antigen | Authors: | Ye, Y, Huang, H. | Deposit date: | 2020-01-06 | Release date: | 2020-12-23 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (3.72 Å) | Cite: | Substrate-binding destabilizes the hydrophobic cluster to relieve the autoinhibition of bacterial ubiquitin ligase IpaH9.8. Commun Biol, 3, 2020
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5FAE
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![BU of 5fae by Molmil](/molmil-images/mine/5fae) | N184K pathological variant of gelsolin domain 2 (trigonal form) | Descriptor: | CALCIUM ION, CHLORIDE ION, DI(HYDROXYETHYL)ETHER, ... | Authors: | Boni, F, Milani, M, Ricagno, S, Bolognesi, M, de Rosa, M. | Deposit date: | 2015-12-11 | Release date: | 2016-10-05 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | Molecular basis of a novel renal amyloidosis due to N184K gelsolin variant. Sci Rep, 6, 2016
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6LTN
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![BU of 6ltn by Molmil](/molmil-images/mine/6ltn) | cryo-EM structure of C-terminal truncated human Pannexin1 | Descriptor: | Pannexin-1 | Authors: | Mou, L.Q, Ke, M, Xiao, Q.J, Wu, J.P, Deng, D. | Deposit date: | 2020-01-23 | Release date: | 2020-05-13 | Last modified: | 2020-05-27 | Method: | ELECTRON MICROSCOPY (3.1 Å) | Cite: | Structural basis for gating mechanism of Pannexin 1 channel. Cell Res., 30, 2020
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6M02
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![BU of 6m02 by Molmil](/molmil-images/mine/6m02) | cryo-EM structure of human Pannexin 1 channel | Descriptor: | Pannexin-1 | Authors: | Ronggui, Q, Lili, D, Jilin, Z, Xuekui, Y, Lei, W, Shujia, Z. | Deposit date: | 2020-02-19 | Release date: | 2020-03-25 | Last modified: | 2020-05-27 | Method: | ELECTRON MICROSCOPY (3.2 Å) | Cite: | Cryo-EM structure of human heptameric Pannexin 1 channel. Cell Res., 30, 2020
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4L2Y
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![BU of 4l2y by Molmil](/molmil-images/mine/4l2y) | Crystal Structure of p110alpha complexed with niSH2 of p85alpha and compound 9d | Descriptor: | 3-amino-5-[4-(morpholin-4-yl)pyrido[3',2':4,5]furo[3,2-d]pyrimidin-2-yl]phenol, GLYCEROL, Phosphatidylinositol 3-kinase regulatory subunit alpha, ... | Authors: | Zhang, J, Zhao, Y.L, Chen, Y.Y, Huang, M, Jiang, F. | Deposit date: | 2013-06-05 | Release date: | 2014-01-01 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Crystal Structures of PI3K alpha Complexed with PI103 and Its Derivatives: New Directions for Inhibitors Design. ACS Med Chem Lett, 5, 2014
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5FFG
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![BU of 5ffg by Molmil](/molmil-images/mine/5ffg) | Crystal structure of integrin alpha V beta 6 head | Descriptor: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | Authors: | Dong, X, Springer, T.A. | Deposit date: | 2015-12-18 | Release date: | 2017-01-25 | Last modified: | 2020-07-29 | Method: | X-RAY DIFFRACTION (2.25 Å) | Cite: | Force interacts with macromolecular structure in activation of TGF-beta. Nature, 542, 2017
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4I1Q
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![BU of 4i1q by Molmil](/molmil-images/mine/4i1q) | Crystal Structure of hBRAP1 N-BAR domain | Descriptor: | Bridging integrator 2 | Authors: | Sanchez-Barrena, M.J. | Deposit date: | 2012-11-21 | Release date: | 2013-02-06 | Last modified: | 2024-03-20 | Method: | X-RAY DIFFRACTION (2.53 Å) | Cite: | Bin2 Is a Membrane Sculpting N-BAR Protein That Influences Leucocyte Podosomes, Motility and Phagocytosis Plos One, 7, 2012
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5SVA
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![BU of 5sva by Molmil](/molmil-images/mine/5sva) | Mediator-RNA Polymerase II Pre-Initiation Complex | Descriptor: | 108bp HIS4 Promoter Non-template Strand (-92/+16), 108bp HIS4 Promoter Template Strand (+16/-92), DNA repair helicase RAD25, ... | Authors: | Robinson, P.J, Bushnell, D.A, Kornberg, R.D. | Deposit date: | 2016-08-05 | Release date: | 2016-09-28 | Last modified: | 2019-11-27 | Method: | ELECTRON MICROSCOPY (15.3 Å) | Cite: | Structure of a Complete Mediator-RNA Polymerase II Pre-Initiation Complex. Cell, 166, 2016
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6N8S
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![BU of 6n8s by Molmil](/molmil-images/mine/6n8s) | |
8H05
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![BU of 8h05 by Molmil](/molmil-images/mine/8h05) | |
8H03
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![BU of 8h03 by Molmil](/molmil-images/mine/8h03) | |
8H04
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![BU of 8h04 by Molmil](/molmil-images/mine/8h04) | |
6N8R
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![BU of 6n8r by Molmil](/molmil-images/mine/6n8r) | |
3N5C
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![BU of 3n5c by Molmil](/molmil-images/mine/3n5c) | Crystal Structure of Arf6DELTA13 complexed with GDP | Descriptor: | ADP-ribosylation factor 6, CHLORIDE ION, GUANOSINE-5'-DIPHOSPHATE | Authors: | Aizel, K, Biou, V, Cherfils, J. | Deposit date: | 2010-05-25 | Release date: | 2010-08-18 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (1.82 Å) | Cite: | SAXS and X-ray crystallography suggest an unfolding model for the GDP/GTP conformational switch of the small GTPase Arf6. J.Mol.Biol., 402, 2010
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3NKJ
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![BU of 3nkj by Molmil](/molmil-images/mine/3nkj) | |
6N8Q
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![BU of 6n8q by Molmil](/molmil-images/mine/6n8q) | |
6N8P
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![BU of 6n8p by Molmil](/molmil-images/mine/6n8p) | |
4L23
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![BU of 4l23 by Molmil](/molmil-images/mine/4l23) | Crystal Structure of p110alpha complexed with niSH2 of p85alpha and PI-103 | Descriptor: | 3-(4-MORPHOLIN-4-YLPYRIDO[3',2':4,5]FURO[3,2-D]PYRIMIDIN-2-YL)PHENOL, GLYCEROL, Phosphatidylinositol 3-kinase regulatory subunit alpha, ... | Authors: | Zhang, J, Zhao, Y.L, Chen, Y.Y, Huang, M, Jiang, F. | Deposit date: | 2013-06-04 | Release date: | 2014-01-01 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (2.501 Å) | Cite: | Crystal Structures of PI3K alpha Complexed with PI103 and Its Derivatives: New Directions for Inhibitors Design. ACS Med Chem Lett, 5, 2014
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4GQK
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![BU of 4gqk by Molmil](/molmil-images/mine/4gqk) | Structure of Native VgrG1-ACD with ADP (no cations) | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, SULFATE ION, VgrG protein | Authors: | Nguyen, V.S, Spinelli, S, Derrez, E, Durand, E, Cambillau, C. | Deposit date: | 2012-08-23 | Release date: | 2013-09-25 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (2.36 Å) | Cite: | Structure of Native VgrG1-ACD with ADP (no cations) To be Published
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2ODB
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![BU of 2odb by Molmil](/molmil-images/mine/2odb) | The crystal structure of human cdc42 in complex with the CRIB domain of human p21-activated kinase 6 (PAK6) | Descriptor: | CHLORIDE ION, Human Cell Division Cycle 42 (CDC42), MAGNESIUM ION, ... | Authors: | Ugochukwu, E, Yang, X, Elkins, J, Soundararajan, M, Pike, A.C.W, Eswaran, J, Burgess, N, Debreczeni, J.E, Sundstrom, M, Arrowsmith, C, Weigelt, J, Edwards, A, Gileadi, O, von Delft, F, Knapp, S, Doyle, D, Structural Genomics Consortium (SGC) | Deposit date: | 2006-12-22 | Release date: | 2007-01-30 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | The crystal structure of human cdc42 in complex with the CRIB domain of human p21-activated kinase 6 (PAK6) To be Published
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3KZ1
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![BU of 3kz1 by Molmil](/molmil-images/mine/3kz1) | Crystal Structure of the Complex of PDZ-RhoGEF DH/PH domains with GTP-gamma-S Activated RhoA | Descriptor: | 5'-GUANOSINE-DIPHOSPHATE-MONOTHIOPHOSPHATE, MAGNESIUM ION, Rho guanine nucleotide exchange factor 11, ... | Authors: | Chen, Z, Sternweis, P.C, Sprang, S.R. | Deposit date: | 2009-12-07 | Release date: | 2010-04-28 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | Activated RhoA binds to the pleckstrin homology (PH) domain of PDZ-RhoGEF, a potential site for autoregulation. J.Biol.Chem., 285, 2010
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6RLC
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![BU of 6rlc by Molmil](/molmil-images/mine/6rlc) | Crystal structure of the PDZ tandem of syntenin in complex with fragment F13 | Descriptor: | (2~{S})-2-[3-(4-chlorophenyl)sulfanylpropanoylamino]-3-methyl-butanoic acid, ACETATE ION, Syntenin-1 | Authors: | Feracci, M, Barral, K. | Deposit date: | 2019-05-02 | Release date: | 2021-02-03 | Last modified: | 2024-05-15 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Pharmacological inhibition of syntenin PDZ2 domain impairs breast cancer cell activities and exosome loadifing with syndecan and EpCAM cargo. J Extracell Vesicles, 10, 2020
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1OZS
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![BU of 1ozs by Molmil](/molmil-images/mine/1ozs) | |
3MYE
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![BU of 3mye by Molmil](/molmil-images/mine/3mye) | |