6RLC
Crystal structure of the PDZ tandem of syntenin in complex with fragment F13
Summary for 6RLC
Entry DOI | 10.2210/pdb6rlc/pdb |
Descriptor | Syntenin-1, (2~{S})-2-[3-(4-chlorophenyl)sulfanylpropanoylamino]-3-methyl-butanoic acid, ACETATE ION, ... (4 entities in total) |
Functional Keywords | signaling protein cell adhesion pdz domain syntenin syndecan drug design, signaling protein |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 4 |
Total formula weight | 73515.15 |
Authors | Feracci, M.,Barral, K. (deposition date: 2019-05-02, release date: 2021-02-03, Last modification date: 2024-05-15) |
Primary citation | Leblanc, R.,Kashyap, R.,Barral, K.,Egea-Jimenez, A.L.,Kovalskyy, D.,Feracci, M.,Garcia, M.,Derviaux, C.,Betzi, S.,Ghossoub, R.,Platonov, M.,Roche, P.,Morelli, X.,Hoffer, L.,Zimmermann, P. Pharmacological inhibition of syntenin PDZ2 domain impairs breast cancer cell activities and exosome loadifing with syndecan and EpCAM cargo. J Extracell Vesicles, 10:e12039-e12039, 2020 Cited by PubMed: 33343836DOI: 10.1002/jev2.12039 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.2 Å) |
Structure validation
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