PDB: 342 resultsInfo pagesStatus searchChemie searchBIRD

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3NKF	Crystal structure of human ligand-free mature caspase-6 with intersubunit linker attached Descriptor: Caspase-6 Authors: Vaidya, S, Hardy, J.A. Deposit date: 2010-06-18 Release date: 2010-12-08 Last modified: 2024-02-21 Method: X-RAY DIFFRACTION (2.9 Å) Cite: Substrate-Induced Conformational Changes Occur in All Cleaved Forms of Caspase-6. J.Mol.Biol., 406, 2011
3NS7	Succinic Acid Amides as P2-P3 Replacements for Inhibitors of Interleukin-1beta Converting Enzyme (ICE or Caspase 1) Descriptor: (3S)-4-hydroxy-3-{[(2S)-4-{[2-(2-methyl-1H-benzimidazol-1-yl)ethyl]amino}-2-(1-methylethyl)-4-oxobutanoyl]amino}butanoic acid, Caspase-1 Authors: Galatsis, P. Deposit date: 2010-07-01 Release date: 2011-08-17 Last modified: 2023-12-27 Method: X-RAY DIFFRACTION (2.6 Å) Cite: Succinic acid amides as P2-P3 replacements for inhibitors of interleukin-1beta converting enzyme (ICE or caspase 1). Bioorg.Med.Chem.Lett., 20, 2010
3NR2	Crystal structure of Caspase-6 zymogen Descriptor: Caspase-6 Authors: Su, X.-D, Wang, X.-J, Liu, X, Mi, W, Wang, K.-T. Deposit date: 2010-06-30 Release date: 2010-10-27 Last modified: 2023-11-01 Method: X-RAY DIFFRACTION (2.9 Å) Cite: Crystal structures of human caspase 6 reveal a new mechanism for intramolecular cleavage self-activation Embo Rep., 11, 2010
3OD5	Crystal structure of active caspase-6 bound with Ac-VEID-CHO Descriptor: CACODYLATE ION, Caspase-6, peptide aldehyde inhibitor AC-VEID-CHO Authors: Wang, X.-J, Liu, X, Wang, K.-T, Cao, Q, Su, X.-D. Deposit date: 2010-08-11 Release date: 2010-10-27 Last modified: 2023-12-06 Method: X-RAY DIFFRACTION (1.6 Å) Cite: Crystal structures of human caspase 6 reveal a new mechanism for intramolecular cleavage self-activation Embo Rep., 11, 2010
3P4U	Crystal structure of active caspase-6 in complex with Ac-VEID-CHO inhibitor Descriptor: Ac-VEID-CHO inhibitor, Caspase-6 Authors: Mueller, I, Lamers, M.B.A.C, Ritchie, A.J, Dominguez, C, Munoz, I, Maillard, M, Kiselyov, A. Deposit date: 2010-10-07 Release date: 2011-09-28 Last modified: 2015-12-02 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Crystal structures of active and inhibitor-bound human Casp6 To be Published
3P45	Crystal structure of apo-caspase-6 at physiological pH Descriptor: caspase-6 Authors: Mueller, I, Lamers, M.B.A.C, Ritchie, A.J, Dominguez, C, Munoz, I, Maillard, M, Kiselyov, A. Deposit date: 2010-10-06 Release date: 2011-06-15 Last modified: 2024-02-21 Method: X-RAY DIFFRACTION (2.53 Å) Cite: Crystal structures of active and inhibitor-bound human Casp6 To be Published
3PCX	Caspase-3 E246A, K242A Double Mutant Descriptor: Caspase-3, Inhibitor Ac-DEVD-CMK Authors: Walters, J, Swartz, P, Mattos, C, Clark, A.C. Deposit date: 2010-10-22 Release date: 2011-02-23 Last modified: 2012-12-12 Method: X-RAY DIFFRACTION (1.5 Å) Cite: Thermodynamic, enzymatic and structural effects of removing a salt bridge at the base of loop 4 in (pro)caspase-3. Arch.Biochem.Biophys., 508, 2011
3PD1	Caspase-3 K242A Descriptor: Caspase-3, Inhibitor Ac-DEVD-CMK Authors: Walters, J, Swartz, P, Mattos, C, Clark, A.C. Deposit date: 2010-10-22 Release date: 2011-02-23 Last modified: 2013-02-27 Method: X-RAY DIFFRACTION (1.62 Å) Cite: Thermodynamic, enzymatic and structural effects of removing a salt bridge at the base of loop 4 in (pro)caspase-3. Arch.Biochem.Biophys., 508, 2011
3PD0	Caspase-3 E246A Descriptor: CHLORIDE ION, Caspase-3, INHIBITOR AC-DEVD-CMK Authors: Walters, J, Swartz, P, Mattos, C, Clark, A.C. Deposit date: 2010-10-22 Release date: 2011-02-16 Last modified: 2012-12-12 Method: X-RAY DIFFRACTION (2 Å) Cite: Thermodynamic, enzymatic and structural effects of removing a salt bridge at the base of loop 4 in (pro)caspase-3. Arch.Biochem.Biophys., 508, 2011
3QNW	Caspase-6 in complex with Z-VAD-FMK inhibitor Descriptor: Caspase-6, Z-VAD-FMK Authors: Mueller, I, Lamers, M, Ritchie, A, Park, H, Dominguez, C, Munoz, I, Maillard, M, Kiselyov, A. Deposit date: 2011-02-09 Release date: 2011-09-21 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (2.65 Å) Cite: Structure of human caspase-6 in complex with Z-VAD-FMK: New peptide binding mode observed for the non-canonical caspase conformation. Bioorg.Med.Chem.Lett., 21, 2011
3R5K	A designed redox-controlled caspase-7 Descriptor: Caspase-7, FORMIC ACID Authors: Witkowski, W.A, Hardy, J.A. Deposit date: 2011-03-18 Release date: 2011-06-29 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (2.86 Å) Cite: A designed redox-controlled caspase. Protein Sci., 20, 2011
3RJM	CASPASE2 IN COMPLEX WITH CHDI LIGAND 33c Descriptor: Caspase-2, Peptide inhibitor (ACE)VDV(3PX)D-CHO Authors: Abendroth, J, Lorimer, D, Stewart, L, Maillard, M, Kiselyov, A.S. Deposit date: 2011-04-15 Release date: 2011-09-21 Last modified: 2023-12-06 Method: X-RAY DIFFRACTION (2.55 Å) Cite: Exploiting differences in caspase-2 and -3 S(2) subsites for selectivity: Structure-based design, solid-phase synthesis and in vitro activity of novel substrate-based caspase-2 inhibitors. Bioorg.Med.Chem., 19, 2011
3R6G	Crystal structure of active caspase-2 bound with Ac-VDVAD-CHO Descriptor: Caspase-2 subunit p12, Caspase-2 subunit p18, Peptide Inhibitor (ACE)VDVAD-CHO Authors: Tang, Y, Wells, J, Arkin, M. Deposit date: 2011-03-21 Release date: 2011-07-27 Last modified: 2012-12-12 Method: X-RAY DIFFRACTION (2.07 Å) Cite: Structural and enzymatic insights into caspase-2 protein substrate recognition and catalysis. J.Biol.Chem., 286, 2011
3R7S	Crystal Structure of Apo Caspase2 Descriptor: Caspase-2 subunit p12, Caspase-2 subunit p18 Authors: Tang, Y, Wells, J, Arkin, M. Deposit date: 2011-03-22 Release date: 2011-07-27 Last modified: 2019-07-17 Method: X-RAY DIFFRACTION (2.252 Å) Cite: Structural and enzymatic insights into caspase-2 protein substrate recognition and catalysis. J.Biol.Chem., 286, 2011
3R5J	Crystal structure of active caspase-2 bound with Ac-ADVAD-CHO Descriptor: Caspase-2 subunit p12, Caspase-2 subunit p18, Peptide Inhibitor (ACE)ADVAD-CHO Authors: Tang, Y, Wells, J, Arkin, M. Deposit date: 2011-03-18 Release date: 2011-07-27 Last modified: 2012-12-12 Method: X-RAY DIFFRACTION (1.77 Å) Cite: Structural and enzymatic insights into caspase-2 protein substrate recognition and catalysis. J.Biol.Chem., 286, 2011
3R6L	Caspase-2 T380A bound with Ac-VDVAD-CHO Descriptor: Caspase-2 subunit p12, Caspase-2 subunit p18, Peptide Inhibitor (ACE)VDVAD-CHO Authors: Tang, Y, Wells, J, Arkin, M. Deposit date: 2011-03-21 Release date: 2011-07-27 Last modified: 2012-12-12 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Structural and enzymatic insights into caspase-2 protein substrate recognition and catalysis. J.Biol.Chem., 286, 2011
3R7B	Caspase-2 bound to one copy of Ac-DVAD-CHO Descriptor: Caspase-2 subunit p12, Caspase-2 subunit p18, Peptide Inhibitor (ACE)DVAD-CHO Authors: Tang, Y, Wells, J, Arkin, M. Deposit date: 2011-03-22 Release date: 2011-07-27 Last modified: 2012-12-12 Method: X-RAY DIFFRACTION (1.8 Å) Cite: Structural and enzymatic insights into caspase-2 protein substrate recognition and catalysis. J.Biol.Chem., 286, 2011
3R7N	Caspase-2 bound with two copies of Ac-DVAD-CHO Descriptor: Caspase-2 subunit p12, Caspase-2 subunit p18, Peptide Inhibitor (ACE)DVAD-CHO Authors: Tang, Y, Wells, J, Arkin, M. Deposit date: 2011-03-22 Release date: 2011-07-27 Last modified: 2012-12-12 Method: X-RAY DIFFRACTION (2.33 Å) Cite: Structural and enzymatic insights into caspase-2 protein substrate recognition and catalysis. J.Biol.Chem., 286, 2011
3S70	Crystal structure of active caspase-6 bound with Ac-VEID-CHO solved by As-SAD Descriptor: ACETATE ION, CACODYLATE ION, Caspase-6, ... Authors: Su, X.-D, Liu, X, Wang, X.-J. Deposit date: 2011-05-26 Release date: 2012-04-11 Last modified: 2012-12-12 Method: X-RAY DIFFRACTION (1.625 Å) Cite: Get phases from arsenic anomalous scattering: de novo SAD phasing of two protein structures crystallized in cacodylate buffer Plos One, 6, 2011
3SIR	Crystal Structure of drICE Descriptor: Caspase Authors: Li, X, Wang, J, Shi, Y. Deposit date: 2011-06-20 Release date: 2011-08-10 Last modified: 2023-11-01 Method: X-RAY DIFFRACTION (2.68 Å) Cite: Structural mechanisms of DIAP1 auto-inhibition and DIAP1-mediated inhibition of drICE. Nat Commun, 2, 2011
3S8E	Phosphorylation regulates assembly of the caspase-6 substrate-binding groove Descriptor: Caspase-6 Authors: Velazquez-Delgado, E.M, Hardy, J.A. Deposit date: 2011-05-27 Release date: 2012-04-11 Last modified: 2023-11-01 Method: X-RAY DIFFRACTION (2.88 Å) Cite: Phosphorylation regulates assembly of the caspase-6 substrate-binding groove. Structure, 20, 2012
1PAU	Crystal structure of the complex of apopain with the tetrapeptide aldehyde inhibitor AC-DEVD-CHO Descriptor: ACE-ASP-GLU-VAL-ASJ, APOPAIN Authors: Rotonda, J, Becker, J.W. Deposit date: 1996-06-06 Release date: 1997-07-07 Last modified: 2023-08-09 Method: X-RAY DIFFRACTION (2.5 Å) Cite: The three-dimensional structure of apopain/CPP32, a key mediator of apoptosis. Nat.Struct.Biol., 3, 1996
1PYO	Crystal Structure of Human Caspase-2 in Complex with Acetyl-Leu-Asp-Glu-Ser-Asp-cho Descriptor: ACETYL-LEU-ASP-GLU-SER-ASJ, Caspase-2 Authors: Schweizer, A, Briand, C, Grutter, M.G. Deposit date: 2003-07-09 Release date: 2003-08-26 Last modified: 2023-11-15 Method: X-RAY DIFFRACTION (1.65 Å) Cite: Crystal structure of caspase-2, apical initiator of the intrinsic apoptotic pathway. J.Biol.Chem., 278, 2003
1QDU	CRYSTAL STRUCTURE OF THE COMPLEX OF CASPASE-8 WITH THE TRIPEPTIDE KETONE INHIBITOR ZEVD-DCBMK Descriptor: CASPASE-8 ALPHA-CHAIN, CASPASE-8 BETA-CHAIN, PHQ-GLU-VAL-ASP-DICHLOROMETHYLKETONE INHIBITOR Authors: Blanchard, H, Grutter, M.G. Deposit date: 1999-07-10 Release date: 2000-07-10 Last modified: 2024-04-03 Method: X-RAY DIFFRACTION (2.8 Å) Cite: The three-dimensional structure of caspase-8: an initiator enzyme in apoptosis. Structure Fold.Des., 7, 1999
1QTN	CRYSTAL STRUCTURE OF THE COMPLEX OF CASPASE-8 WITH THE TETRAPEPTIDE INHIBITOR ACE-IETD-ALDEHYDE Descriptor: ACETYL-ILE-GLU-THR-ASP-ALDEHYDE, CASPASE-8, DITHIANE DIOL Authors: Watt, W, Watenpaugh, K.D. Deposit date: 1999-06-28 Release date: 2000-09-20 Last modified: 2023-11-15 Method: X-RAY DIFFRACTION (1.2 Å) Cite: The atomic-resolution structure of human caspase-8, a key activator of apoptosis. Structure Fold.Des., 7, 1999

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