1QTN

CRYSTAL STRUCTURE OF THE COMPLEX OF CASPASE-8 WITH THE TETRAPEPTIDE INHIBITOR ACE-IETD-ALDEHYDE

Summary for 1QTN

Related PRD IDPRD_000301
DescriptorCASPASE-8, ACETYL-ILE-GLU-THR-ASP-ALDEHYDE, DITHIANE DIOL, ... (5 entities in total)
Functional Keywordsapoptosis, dithiane-diol, caspase, cysteine-protease, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological sourceHomo sapiens (human)
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Cellular locationCytoplasm Q14790 Q14790
Total number of polymer chains3
Total molecular weight30334.49
Authors
Watt, W.,Watenpaugh, K.D. (deposition date: 1999-06-28, release date: 2000-09-20, Last modification date: 2012-12-12)
Primary citation
Watt, W.,Koeplinger, K.A.,Mildner, A.M.,Heinrikson, R.L.,Tomasselli, A.G.,Watenpaugh, K.D.
The atomic-resolution structure of human caspase-8, a key activator of apoptosis.
Structure Fold.Des., 7:1135-1143, 1999
PubMed: 10508785 (PDB entries with the same primary citation)
DOI: 10.1016/S0969-2126(99)80180-4
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (1.2 Å)
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Structure validation

ClashscoreRamachandran outliersSidechain outliers50 1.8%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
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171588
PDB entries from 2020-11-25