8P25
 
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1U6F
 | | NMR solution structure of TcUBP1, a single RBD-unit from Trypanosoma cruzi | | 分子名称: | RNA-binding protein UBP1 | | 著者 | Volpon, L, D'orso, I, Frasch, A, Gehring, K. | | 登録日 | 2004-07-29 | | 公開日 | 2005-01-25 | | 最終更新日 | 2024-05-22 | | 実験手法 | SOLUTION NMR | | 主引用文献 | NMR Structural Study of TcUBP1, a Single RRM Domain Protein from Trypanosoma cruzi: Contribution of a beta Hairpin to RNA Binding
Biochemistry, 44, 2005
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6Y24
 | | Crystal structure of fourth KH domain of FUBP1 | | 分子名称: | 1,2-ETHANEDIOL, Far upstream element-binding protein 1 | | 著者 | Ni, X, Joerger, A.C, Chaikuad, A, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Knapp, S, Structural Genomics Consortium (SGC) | | 登録日 | 2020-02-14 | | 公開日 | 2020-03-25 | | 最終更新日 | 2024-01-24 | | 実験手法 | X-RAY DIFFRACTION (1.86 Å) | | 主引用文献 | Comparative structural analyses and nucleotide-binding characterization of the four KH domains of FUBP1.
Sci Rep, 10, 2020
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6Y2D
 | | Crystal structure of the second KH domain of FUBP1 | | 分子名称: | Far upstream element-binding protein 1, GLYCEROL, SULFATE ION | | 著者 | Ni, X, Chaikuad, A, Joerger, A.C, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Knapp, S, Structural Genomics Consortium (SGC) | | 登録日 | 2020-02-15 | | 公開日 | 2020-03-25 | | 最終更新日 | 2024-01-24 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | Comparative structural analyses and nucleotide-binding characterization of the four KH domains of FUBP1.
Sci Rep, 10, 2020
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6Y2C
 | | Crystal structure of the third KH domain of FUBP1 | | 分子名称: | 1,2-ETHANEDIOL, Far upstream element-binding protein 1, ZINC ION | | 著者 | Ni, X, Joerger, A.C, Chaikuad, A, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Knapp, S, Structural Genomics Consortium (SGC) | | 登録日 | 2020-02-15 | | 公開日 | 2020-03-25 | | 最終更新日 | 2024-01-24 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Comparative structural analyses and nucleotide-binding characterization of the four KH domains of FUBP1.
Sci Rep, 10, 2020
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4LIJ
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6RR0
 | | Crystal structure of the Sir4 H-BRCT domain in complex with Ubp10 pT123 peptide | | 分子名称: | CHLORIDE ION, Regulatory protein SIR4, Ubiquitin carboxyl-terminal hydrolase 10 | | 著者 | Deshpande, I, Keusch, J.J, Challa, K, Iesmantavicius, V, Gasser, S.M, Gut, H. | | 登録日 | 2019-05-16 | | 公開日 | 2019-09-18 | | 最終更新日 | 2019-10-23 | | 実験手法 | X-RAY DIFFRACTION (2.18 Å) | | 主引用文献 | The Sir4 H-BRCT domain interacts with phospho-proteins to sequester and repress yeast heterochromatin.
Embo J., 38, 2019
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2KXH
 | | Solution structure of the first two RRM domains of FIR in the complex with FBP Nbox peptide | | 分子名称: | Poly(U)-binding-splicing factor PUF60, peptide of Far upstream element-binding protein 1 | | 著者 | Cukier, C.D, Ramos, A, Hollingworth, D, Diaz-Moreno, I, Kelly, G. | | 登録日 | 2010-05-05 | | 公開日 | 2010-08-18 | | 最終更新日 | 2024-05-01 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Molecular basis of FIR-mediated c-myc transcriptional control.
Nat.Struct.Mol.Biol., 17, 2010
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1J4W
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1X4M
 | | Solution structure of KH domain in Far upstream element binding protein 1 | | 分子名称: | Far upstream element binding protein 1 | | 著者 | He, F, Muto, Y, Inoue, M, Kigawa, T, Shirouzu, M, Terada, T, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) | | 登録日 | 2005-05-14 | | 公開日 | 2005-11-14 | | 最終更新日 | 2024-05-29 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Solution structure of KH domain in Far upstream element binding protein 1
To be Published
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1X4N
 | | Solution structure of KH domain in FUSE binding protein 1 | | 分子名称: | Far upstream element binding protein 1 | | 著者 | He, F, Muto, Y, Inoue, M, Kigawa, T, Shirouzu, M, Terada, T, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) | | 登録日 | 2005-05-14 | | 公開日 | 2005-11-14 | | 最終更新日 | 2024-05-29 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Solution structure of KH domain in FUSE binding protein 1
To be Published
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7AY1
 | | Cryo-EM structure of USP1-UAF1 bound to mono-ubiquitinated FANCD2, and FANCI | | 分子名称: | DNA (61-MER), Fanconi anemia group D2 protein, Fanconi anemia group I protein, ... | | 著者 | Rennie, M.L, Arkinson, C, Walden, H. | | 登録日 | 2020-11-10 | | 公開日 | 2021-03-24 | | 最終更新日 | 2022-07-27 | | 実験手法 | ELECTRON MICROSCOPY (3.7 Å) | | 主引用文献 | Structural basis of FANCD2 deubiquitination by USP1-UAF1.
Nat.Struct.Mol.Biol., 28, 2021
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9FCJ
 | | USP1 bound to ML323 and ubiquitin conjugated to FANCD2 (ordered subset, focused refinement) | | 分子名称: | 5-methyl-2-(2-propan-2-ylphenyl)-~{N}-[[4-(1,2,3-triazol-1-yl)phenyl]methyl]pyrimidin-4-amine, Polyubiquitin-C, Ubiquitin carboxyl-terminal hydrolase 1, ... | | 著者 | Rennie, M.L, Gundogdu, M, Walden, H. | | 登録日 | 2024-05-15 | | 公開日 | 2024-09-04 | | 実験手法 | ELECTRON MICROSCOPY (2.7 Å) | | 主引用文献 | Structural and Biochemical Insights into the Mechanism of Action of the Clinical USP1 Inhibitor, KSQ-4279.
J.Med.Chem., 2024
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9FCI
 | | USP1 bound to KSQ-4279 and ubiquitin conjugated to FANCD2 (focused refinement) | | 分子名称: | 6-(4-cyclopropyl-6-methoxy-pyrimidin-5-yl)-1-[[4-[1-propan-2-yl-4-(trifluoromethyl)imidazol-2-yl]phenyl]methyl]pyrazolo[3,4-d]pyrimidine, Polyubiquitin-C, Ubiquitin carboxyl-terminal hydrolase 1, ... | | 著者 | Rennie, M.L, Gundogdu, M, Walden, H. | | 登録日 | 2024-05-15 | | 公開日 | 2024-09-04 | | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | | 主引用文献 | Structural and Biochemical Insights into the Mechanism of Action of the Clinical USP1 Inhibitor, KSQ-4279.
J.Med.Chem., 2024
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8A9J
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8A9K
 | | Cryo-EM structure of USP1-UAF1 bound to FANCI and mono-ubiquitinated FANCD2 with ML323 (consensus reconstruction) | | 分子名称: | 5-methyl-2-(2-propan-2-ylphenyl)-~{N}-[[4-(1,2,3-triazol-1-yl)phenyl]methyl]pyrimidin-4-amine, DNA (61-MER), Fanconi anemia group D2 protein, ... | | 著者 | Rennie, M.L, Walden, H. | | 登録日 | 2022-06-28 | | 公開日 | 2022-10-12 | | 最終更新日 | 2023-03-01 | | 実験手法 | ELECTRON MICROSCOPY (2.85 Å) | | 主引用文献 | Cryo-EM reveals a mechanism of USP1 inhibition through a cryptic binding site.
Sci Adv, 8, 2022
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7ZH4
 | | USP1 bound to ML323 and ubiquitin conjugated to FANCD2 (focused refinement) | | 分子名称: | 5-methyl-2-(2-propan-2-ylphenyl)-~{N}-[[4-(1,2,3-triazol-1-yl)phenyl]methyl]pyrimidin-4-amine, Ubiquitin carboxyl-terminal hydrolase 1, Ubiquitin-60S ribosomal protein L40, ... | | 著者 | Rennie, M.L, Walden, H. | | 登録日 | 2022-04-05 | | 公開日 | 2022-10-12 | | 最終更新日 | 2024-07-24 | | 実験手法 | ELECTRON MICROSCOPY (2.49 Å) | | 主引用文献 | Cryo-EM reveals a mechanism of USP1 inhibition through a cryptic binding site.
Sci Adv, 8, 2022
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7ZH3
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3LMN
 | | Oligomeric structure of the DUSP domain of human USP15 | | 分子名称: | ACETIC ACID, FORMIC ACID, Ubiquitin carboxyl-terminal hydrolase 15 | | 著者 | Walker, J.R, Asinas, A, Avvakumov, G.V, Alenkin, D, Weigelt, J, Bountra, C, Edwards, A.M, Arrowsmith, C.H, Bochkarev, A, Dhe-Paganon, S. | | 登録日 | 2010-01-31 | | 公開日 | 2010-03-23 | | 最終更新日 | 2023-09-06 | | 実験手法 | X-RAY DIFFRACTION (2.15 Å) | | 主引用文献 | Crystal Structure of the Human Ubiquitin-Specific Protease 15 DUSP Domain
To be Published
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6ML1
 | | Structure of the USP15 deubiquitinase domain in complex with an affinity-matured inhibitory Ubv | | 分子名称: | 1,2-ETHANEDIOL, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, CALCIUM ION, ... | | 著者 | Singer, A.U, Teyra, J, Boehmelt, G, Lenter, M, Sicheri, F, Sidhu, S.S. | | 登録日 | 2018-09-26 | | 公開日 | 2019-01-23 | | 最終更新日 | 2023-10-25 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | Structural and Functional Characterization of Ubiquitin Variant Inhibitors of USP15.
Structure, 27, 2019
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8WG5
 | | Cryo-EM structure of USP16 bound to H2AK119Ub nucleosome | | 分子名称: | DNA (147-MER), Histone H2A type 1-B/E, Histone H2B type 1-K, ... | | 著者 | Ai, H.S, He, Z.Z, Deng, Z.H, Liu, L. | | 登録日 | 2023-09-20 | | 公開日 | 2023-12-27 | | 最終更新日 | 2024-07-10 | | 実験手法 | ELECTRON MICROSCOPY (3.05 Å) | | 主引用文献 | Structural and mechanistic basis for nucleosomal H2AK119 deubiquitination by single-subunit deubiquitinase USP16.
Nat.Struct.Mol.Biol., 2024
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4X3G
 | | Crystal structure of SIAH1 SINA domain in complex with a USP19 peptide | | 分子名称: | E3 ubiquitin-protein ligase SIAH1, Ubiquitin carboxyl-terminal hydrolase 19, ZINC ION | | 著者 | Walker, J.R, Dong, A, Zhang, Q, Huang, X, Li, Y, Bountra, C, Edwards, A.M, Arrowsmith, C.H, Tong, Y, Structural Genomics Consortium (SGC) | | 登録日 | 2014-11-28 | | 公開日 | 2014-12-31 | | 最終更新日 | 2023-09-27 | | 実験手法 | X-RAY DIFFRACTION (2.34 Å) | | 主引用文献 | Crystal structure of SIAH1 SINA domain in complex with a USP19 peptide
To be published
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8TH6
 | | Crystal Structure of the G3BP1 NTF2-like domain bound to USP10 peptide | | 分子名称: | 1,2-ETHANEDIOL, Ras GTPase-activating protein-binding protein 1, Ubiquitin carboxyl-terminal hydrolase 10 | | 著者 | Hughes, M.P, Taylor, J.P, Yang, Z. | | 登録日 | 2023-07-14 | | 公開日 | 2024-03-20 | | 最終更新日 | 2024-05-08 | | 実験手法 | X-RAY DIFFRACTION (2.34 Å) | | 主引用文献 | Interaction between host G3BP and viral nucleocapsid protein regulates SARS-CoV-2 replication and pathogenicity.
Cell Rep, 43, 2024
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3T9L
 | | Structure of N-terminal DUSP-UBL domains of human USP15 | | 分子名称: | SULFATE ION, Ubiquitin carboxyl-terminal hydrolase 15 | | 著者 | Harper, S, Besong, T.M.D, Emsley, J, Scott, D.J, Dreveny, I. | | 登録日 | 2011-08-03 | | 公開日 | 2011-09-28 | | 最終更新日 | 2023-09-13 | | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | | 主引用文献 | Structure of the USP15 N-Terminal Domains: A beta-Hairpin Mediates Close Association between the DUSP and UBL Domains
Biochemistry, 50, 2011
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2I50
 | | Solution Structure of Ubp-M Znf-UBP domain | | 分子名称: | Ubiquitin carboxyl-terminal hydrolase 16, ZINC ION | | 著者 | Pai, M.-T. | | 登録日 | 2006-08-23 | | 公開日 | 2007-08-07 | | 最終更新日 | 2024-05-29 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Solution structure of the Ubp-M BUZ domain, a highly specific protein module that recognizes the C-terminal tail of free ubiquitin.
J.Mol.Biol., 370, 2007
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