9FCJ
USP1 bound to ML323 and ubiquitin conjugated to FANCD2 (ordered subset, focused refinement)
Summary for 9FCJ
Entry DOI | 10.2210/pdb9fcj/pdb |
Related | 7ZH3 7ZH4 9FCI |
EMDB information | 50317 |
Descriptor | Polyubiquitin-C, Ubiquitin carboxyl-terminal hydrolase 1, ZINC ION, ... (5 entities in total) |
Functional Keywords | inhibitor, deubiquitinase, complex, enzyme-substrate, hydrolase |
Biological source | Homo sapiens (human) More |
Total number of polymer chains | 2 |
Total formula weight | 97715.28 |
Authors | |
Primary citation | Rennie, M.L.,Gundogdu, M.,Arkinson, C.,Liness, S.,Frame, S.,Walden, H. Structural and Biochemical Insights into the Mechanism of Action of the Clinical USP1 Inhibitor, KSQ-4279. J.Med.Chem., 2024 Cited by PubMed: 39190802DOI: 10.1021/acs.jmedchem.4c01184 PDB entries with the same primary citation |
Experimental method | ELECTRON MICROSCOPY (2.7 Å) |
Structure validation
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