9FCI
USP1 bound to KSQ-4279 and ubiquitin conjugated to FANCD2 (focused refinement)
This is a non-PDB format compatible entry.
Summary for 9FCI
Entry DOI | 10.2210/pdb9fci/pdb |
Related | 7ZH3 7ZH4 9FCJ |
EMDB information | 50316 |
Descriptor | Ubiquitin carboxyl-terminal hydrolase 1, Polyubiquitin-C, ZINC ION, ... (4 entities in total) |
Functional Keywords | inhibitor, deubiquitinase, complex, enzyme-substrate, hydrolase |
Biological source | Homo sapiens (human) More |
Total number of polymer chains | 2 |
Total formula weight | 97865.34 |
Authors | |
Primary citation | Rennie, M.L.,Gundogdu, M.,Arkinson, C.,Liness, S.,Frame, S.,Walden, H. Structural and Biochemical Insights into the Mechanism of Action of the Clinical USP1 Inhibitor, KSQ-4279. J.Med.Chem., 2024 Cited by PubMed: 39190802DOI: 10.1021/acs.jmedchem.4c01184 PDB entries with the same primary citation |
Experimental method | ELECTRON MICROSCOPY (3.2 Å) |
Structure validation
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