9FCI
USP1 bound to KSQ-4279 and ubiquitin conjugated to FANCD2 (focused refinement)
This is a non-PDB format compatible entry.
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| D | 0001501 | biological_process | skeletal system development |
| D | 0004197 | molecular_function | cysteine-type endopeptidase activity |
| D | 0004843 | molecular_function | cysteine-type deubiquitinase activity |
| D | 0005515 | molecular_function | protein binding |
| D | 0005634 | cellular_component | nucleus |
| D | 0005654 | cellular_component | nucleoplasm |
| D | 0005829 | cellular_component | cytosol |
| D | 0006281 | biological_process | DNA repair |
| D | 0006282 | biological_process | regulation of DNA repair |
| D | 0006508 | biological_process | proteolysis |
| D | 0006974 | biological_process | DNA damage response |
| D | 0007259 | biological_process | cell surface receptor signaling pathway via JAK-STAT |
| D | 0008233 | molecular_function | peptidase activity |
| D | 0008234 | molecular_function | cysteine-type peptidase activity |
| D | 0009411 | biological_process | response to UV |
| D | 0016579 | biological_process | protein deubiquitination |
| D | 0016787 | molecular_function | hydrolase activity |
| D | 0031647 | biological_process | regulation of protein stability |
| D | 0035520 | biological_process | monoubiquitinated protein deubiquitination |
| D | 0046427 | biological_process | positive regulation of receptor signaling pathway via JAK-STAT |
| D | 1904333 | biological_process | positive regulation of error-prone translesion synthesis |
Functional Information from PROSITE/UniProt
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1 |
| Details | ACT_SITE: Nucleophile => ECO:0000269|PubMed:15694335, ECO:0000269|PubMed:16531995, ECO:0000269|PubMed:26388029 |
| Chain | Residue | Details |
| D | SER90 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 1 |
| Details | ACT_SITE: Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU10092, ECO:0000255|PROSITE-ProRule:PRU10093 |
| Chain | Residue | Details |
| D | HIS593 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1 |
| Details | SITE: Cleavage; by autolysis => ECO:0000269|PubMed:16531995 |
| Chain | Residue | Details |
| D | ALA671 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163 |
| Chain | Residue | Details |
| D | SER16 | |
| D | SER313 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:17525332, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:23186163 |
| Chain | Residue | Details |
| D | SER42 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:23186163 |
| Chain | Residue | Details |
| D | SER67 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:23186163 |
| Chain | Residue | Details |
| D | SER475 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:Q8BJQ2 |
| Chain | Residue | Details |
| D | SER768 |
