9FCI

USP1 bound to KSQ-4279 and ubiquitin conjugated to FANCD2 (focused refinement)

This is a non-PDB format compatible entry.

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	D	Ubiquitin carboxyl-terminal hydrolase 1	polymer	786	88390.3	1	UniProt (O94782) In PDB	Homo sapiens (human)	Deubiquitinating enzyme 1,hUBP,Ubiquitin thioesterase 1,Ubiquitin-specific-processing protease 1
2	C	Polyubiquitin-C	polymer	80	8875.1	1	UniProt (P0CG48) In PDB	Homo sapiens (human)
3	D	ZINC ION	non-polymer		65.4	1	Chemie (ZN)
4	D	6-(4-cyclopropyl-6-methoxy-pyrimidin-5-yl)-1-[[4-[1-propan-2-yl-4-(trifluoromethyl)imidazol-2-yl]phenyl]methyl]pyrazolo[3,4-d]pyrimidine	non-polymer		534.5	1	Chemie (A1IB8)

Sequence modifications

D: 1 - 785 (UniProt: O94782)

PDB	External Database	Details
Gly 0	-	expression tag
Ser 90	Cys 90	engineered mutation
Ala 670	Gly 670	engineered mutation
Ala 671	Gly 671	engineered mutation

C: 1 - 76 (UniProt: P0CG48)

PDB	External Database	Details
Gly -3	-	expression tag
Pro -2	-	expression tag
Gly -1	-	expression tag
Ser 0	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	97265.4
Non-Polymers*	Number of molecules	2
	Total formula weight	599.9
All*	Total formula weight	97865.3

*Water molecules are not included.