6ML1
Structure of the USP15 deubiquitinase domain in complex with an affinity-matured inhibitory Ubv
Summary for 6ML1
Entry DOI | 10.2210/pdb6ml1/pdb |
Related | 6CPM 6CRN |
Descriptor | Ubiquitin carboxyl-terminal hydrolase 15,Ubiquitin carboxyl-terminal hydrolase 15,Ubiquitin carboxyl-terminal hydrolase 15, Ubiquitin variant 15.1a, Proteolyzed N-terminal tag of Ubv.15.1a construct, ... (10 entities in total) |
Functional Keywords | deubiuqitination, ubv, high-affinity, inhibition, signaling protein |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 5 |
Total formula weight | 103802.90 |
Authors | Singer, A.U.,Teyra, J.,Boehmelt, G.,Lenter, M.,Sicheri, F.,Sidhu, S.S. (deposition date: 2018-09-26, release date: 2019-01-23, Last modification date: 2023-10-25) |
Primary citation | Teyra, J.,Singer, A.U.,Schmitges, F.W.,Jaynes, P.,Kit Leng Lui, S.,Polyak, M.J.,Fodil, N.,Krieger, J.R.,Tong, J.,Schwerdtfeger, C.,Brasher, B.B.,Ceccarelli, D.F.J.,Moffat, J.,Sicheri, F.,Moran, M.F.,Gros, P.,Eichhorn, P.J.A.,Lenter, M.,Boehmelt, G.,Sidhu, S.S. Structural and Functional Characterization of Ubiquitin Variant Inhibitors of USP15. Structure, 27:590-, 2019 Cited by PubMed: 30713027DOI: 10.1016/j.str.2019.01.002 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.9 Å) |
Structure validation
Download full validation report