7W37
| Structure of USP14-bound human 26S proteasome in state EA1_UBL | 分子名称: | 26S protease regulatory subunit 4, 26S protease regulatory subunit 6A, 26S protease regulatory subunit 6B, ... | 著者 | Zhang, S, Zou, S, Yin, D, Wu, Z, Mao, Y. | 登録日 | 2021-11-25 | 公開日 | 2022-05-04 | 最終更新日 | 2022-06-01 | 実験手法 | ELECTRON MICROSCOPY (3 Å) | 主引用文献 | USP14-regulated allostery of the human proteasome by time-resolved cryo-EM. Nature, 605, 2022
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7W3F
| Structure of USP14-bound human 26S proteasome in substrate-engaged state ED1_USP14 | 分子名称: | 26S protease regulatory subunit 4, 26S protease regulatory subunit 6A, 26S protease regulatory subunit 6B, ... | 著者 | Zhang, S, Zou, S, Yin, D, Wu, Z, Mao, Y. | 登録日 | 2021-11-25 | 公開日 | 2022-05-04 | 最終更新日 | 2022-06-01 | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | 主引用文献 | USP14-regulated allostery of the human proteasome by time-resolved cryo-EM. Nature, 605, 2022
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7W38
| Structure of USP14-bound human 26S proteasome in state EA2.0_UBL | 分子名称: | 26S protease regulatory subunit 4, 26S protease regulatory subunit 6A, 26S protease regulatory subunit 6B, ... | 著者 | Zhang, S, Zou, S, Yin, D, Wu, Z, Mao, Y. | 登録日 | 2021-11-25 | 公開日 | 2022-05-04 | 最終更新日 | 2022-06-01 | 実験手法 | ELECTRON MICROSCOPY (3.1 Å) | 主引用文献 | USP14-regulated allostery of the human proteasome by time-resolved cryo-EM. Nature, 605, 2022
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6SGC
| Rabbit 80S ribosome stalled on a poly(A) tail | 分子名称: | 18S ribosomal RNA, 28S ribosomal RNA, 40S ribosomal protein S12, ... | 著者 | Chandrasekaran, V, Juszkiewicz, S, Choi, J, Puglisi, J.D, Brown, A, Shao, S, Ramakrishnan, V, Hegde, R.S. | 登録日 | 2019-08-03 | 公開日 | 2019-12-04 | 最終更新日 | 2022-03-30 | 実験手法 | ELECTRON MICROSCOPY (2.8 Å) | 主引用文献 | Mechanism of ribosome stalling during translation of a poly(A) tail. Nat.Struct.Mol.Biol., 26, 2019
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7W3K
| Structure of USP14-bound human 26S proteasome in substrate-inhibited state SD4_USP14 | 分子名称: | 26S protease regulatory subunit 4, 26S protease regulatory subunit 6A, 26S protease regulatory subunit 6B, ... | 著者 | Zhang, S, Zou, S, Yin, D, Wu, Z, Mao, Y. | 登録日 | 2021-11-25 | 公開日 | 2022-05-04 | 最終更新日 | 2022-06-01 | 実験手法 | ELECTRON MICROSCOPY (3.6 Å) | 主引用文献 | USP14-regulated allostery of the human proteasome by time-resolved cryo-EM. Nature, 605, 2022
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7W3I
| Structure of USP14-bound human 26S proteasome in substrate-inhibited state SB_USP14 | 分子名称: | 26S protease regulatory subunit 4, 26S protease regulatory subunit 6A, 26S protease regulatory subunit 6B, ... | 著者 | Zhang, S, Zou, S, Yin, D, Wu, Z, Mao, Y. | 登録日 | 2021-11-25 | 公開日 | 2022-05-18 | 最終更新日 | 2022-06-01 | 実験手法 | ELECTRON MICROSCOPY (3.5 Å) | 主引用文献 | USP14-regulated allostery of the human proteasome by time-resolved cryo-EM. Nature, 605, 2022
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7W3M
| Structure of USP14-bound human 26S proteasome in substrate-inhibited state SD5_USP14 | 分子名称: | 26S protease regulatory subunit 4, 26S protease regulatory subunit 6A, 26S protease regulatory subunit 6B, ... | 著者 | Zhang, S, Zou, S, Yin, D, Wu, Z, Mao, Y. | 登録日 | 2021-11-25 | 公開日 | 2022-05-18 | 最終更新日 | 2022-06-01 | 実験手法 | ELECTRON MICROSCOPY (3.5 Å) | 主引用文献 | USP14-regulated allostery of the human proteasome by time-resolved cryo-EM. Nature, 605, 2022
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4RPV
| co-crystal structure of Pim1 with compound 3 | 分子名称: | (3S)-1-{6-[5-(2,6-difluorophenyl)-2H-indazol-3-yl]pyrazin-2-yl}piperidin-3-amine, Serine/threonine-protein kinase pim-1 | 著者 | Huang, X. | 登録日 | 2014-10-31 | 公開日 | 2015-02-04 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (3.05 Å) | 主引用文献 | The discovery of novel 3-(pyrazin-2-yl)-1H-indazoles as potent pan-Pim kinase inhibitors. Bioorg.Med.Chem.Lett., 25, 2015
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4RKW
| Crystal structure of DJ-1 | 分子名称: | Protein DJ-1 | 著者 | Liddington, R.C. | 登録日 | 2014-10-14 | 公開日 | 2015-08-26 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | 主引用文献 | Transnitrosylation from DJ-1 to PTEN attenuates neuronal cell death in parkinson's disease models. J.Neurosci., 34, 2014
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7QFZ
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1U9O
| Crystal structure of the transcriptional regulator EthR in a ligand bound conformation | 分子名称: | HEXADECYL OCTANOATE, Transcriptional repressor EthR | 著者 | Frenois, F, Engohang-Ndong, J, Locht, C, Baulard, A.R, Villeret, V. | 登録日 | 2004-08-10 | 公開日 | 2004-11-16 | 最終更新日 | 2024-03-13 | 実験手法 | X-RAY DIFFRACTION (3.3 Å) | 主引用文献 | Structure of EthR in a Ligand Bound Conformation Reveals Therapeutic Perspectives against Tuberculosis Mol.Cell, 16, 2004
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5YVG
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6R5Q
| Structure of XBP1u-paused ribosome nascent chain complex (post-state) | 分子名称: | 18S ribosomal RNA, 28S ribosomal RNA, 40S ribosomal protein S12, ... | 著者 | Shanmuganathan, V, Cheng, J, Berninghausen, O, Beckmann, R. | 登録日 | 2019-03-25 | 公開日 | 2019-07-10 | 最終更新日 | 2019-10-30 | 実験手法 | ELECTRON MICROSCOPY (3 Å) | 主引用文献 | Structural and mutational analysis of the ribosome-arresting human XBP1u. Elife, 8, 2019
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4S0Z
| Crystal structure of M26V human DJ-1 | 分子名称: | 1,2-ETHANEDIOL, ACETATE ION, Protein DJ-1 | 著者 | Milkovic, N.M, Wilson, M.A. | 登録日 | 2015-01-07 | 公開日 | 2015-08-05 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (1.45 Å) | 主引用文献 | Transient sampling of aggregation-prone conformations causes pathogenic instability of a parkinsonian mutant of DJ-1 at physiological temperature. Protein Sci., 24, 2015
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5FP5
| Structure of cyclin-dependent kinase 2 with small-molecule ligand 4- fluorobenzoic acid (AT222) in an alternate binding site. | 分子名称: | 4-fluorobenzoic acid, ACETYL GROUP, CYCLIN-DEPENDENT KINASE 2 | 著者 | Jhoti, H, Ludlow, R.F, O'Reilly, M, Saini, H.K, Tickle, I.J, Verdonk, M. | 登録日 | 2015-11-27 | 公開日 | 2015-12-09 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (2.16 Å) | 主引用文献 | Detection of Secondary Binding Sites in Proteins Using Fragment Screening. Proc.Natl.Acad.Sci.USA, 112, 2015
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4TL1
| GCN4-p1 with mutation to 1-Aminocyclohexanecarboxylic acid at residue 10 | 分子名称: | General control protein GCN4, ISOPROPYL ALCOHOL | 著者 | Tavenor, N.A, Silva, K.I, Saxena, S, Horne, W.S. | 登録日 | 2014-05-28 | 公開日 | 2014-08-06 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Origins of Structural Flexibility in Protein-Based Supramolecular Polymers Revealed by DEER Spectroscopy. J.Phys.Chem.B, 118, 2014
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8BHF
| Cryo-EM structure of stalled rabbit 80S ribosomes in complex with human CCR4-NOT and CNOT4 | 分子名称: | 18S ribosomal RNA, 28S ribosomal RNA, 40S ribosomal protein S11, ... | 著者 | Absmeier, E, Chandrasekaran, V, O'Reilly, F.J, Stowell, J.A.W, Rappsilber, J, Passmore, L.A. | 登録日 | 2022-10-31 | 公開日 | 2023-09-06 | 最終更新日 | 2023-11-01 | 実験手法 | ELECTRON MICROSCOPY (3.1 Å) | 主引用文献 | Modulation of GluA2-gamma 5 synaptic complex desensitization, polyamine block and antiepileptic perampanel inhibition by auxiliary subunit cornichon-2. Nat.Struct.Mol.Biol., 30, 2023
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6R7Q
| Structure of XBP1u-paused ribosome nascent chain complex with Sec61. | 分子名称: | 18S ribosomal RNA, 28S ribosomal RNA, 40S ribosomal protein S12, ... | 著者 | Shanmuganathan, V, Cheng, J, Braunger, K, Berninghausen, O, Beatrix, B, Beckmann, R. | 登録日 | 2019-03-29 | 公開日 | 2019-07-10 | 最終更新日 | 2024-05-22 | 実験手法 | ELECTRON MICROSCOPY (3.9 Å) | 主引用文献 | Structural and mutational analysis of the ribosome-arresting human XBP1u. Elife, 8, 2019
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6SG4
| Structure of CDK2/cyclin A M246Q, S247EN | 分子名称: | Cyclin-A2, Cyclin-dependent kinase 2 | 著者 | Salamina, M, Basle, A, Massa, B, Noble, M.E.M, Endicott, J.A. | 登録日 | 2019-08-02 | 公開日 | 2021-01-27 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (2.43 Å) | 主引用文献 | Discriminative SKP2 Interactions with CDK-Cyclin Complexes Support a Cyclin A-Specific Role in p27KIP1 Degradation. J.Mol.Biol., 433, 2021
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8ROZ
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8OY2
| Human cyclin-dependent kinase 2 in complex with inhibitor HB-29260 | 分子名称: | (1S,2S,11aS)-1-methoxy-1,4,7,10-tetramethyl-2,9-bis(oxidanyl)-2,11a-dihydrobenzo[b][1,4]benzodioxepine-3,6-dione, Cyclin-dependent kinase 2, GLYCEROL | 著者 | Kordes, S, Harvey, C.J.B. | 登録日 | 2023-05-03 | 公開日 | 2023-11-29 | 最終更新日 | 2023-12-06 | 実験手法 | X-RAY DIFFRACTION (2.618 Å) | 主引用文献 | Resistance gene-guided genome mining reveals the roseopurpurins as inhibitors of cyclin-dependent kinases. Proc.Natl.Acad.Sci.USA, 120, 2023
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6RIJ
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5IEX
| Crystal structure of (R,S)-S-{4-[(5-Bromo-4-{[(2R,3R)-2-hydroxy-1-methylpropyl]oxy}- pyrimidin-2-yl)amino]phenyl}-S-cyclopropylsulfoximide bound to CDK2 | 分子名称: | (2R,3R)-3-[(5-bromo-2-{[4-(S-cyclopropylsulfonimidoyl)phenyl]amino}pyrimidin-4-yl)oxy]butan-2-ol, Cyclin-dependent kinase 2 | 著者 | Ayaz, P, Andres, D, Kwiatkowski, D.A, Kolbe, C, Lienau, P, Siemeister, G, Luecking, U, Stegmann, C.M. | 登録日 | 2016-02-25 | 公開日 | 2016-04-27 | 最終更新日 | 2024-05-08 | 実験手法 | X-RAY DIFFRACTION (2.03 Å) | 主引用文献 | Conformational Adaption May Explain the Slow Dissociation Kinetics of Roniciclib (BAY 1000394), a Type I CDK Inhibitor with Kinetic Selectivity for CDK2 and CDK9. Acs Chem.Biol., 11, 2016
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7W3H
| Structure of USP14-bound human 26S proteasome in substrate-engaged state ED2.1_USP14 | 分子名称: | 26S protease regulatory subunit 4, 26S protease regulatory subunit 6A, 26S protease regulatory subunit 6B, ... | 著者 | Zhang, S, Zou, S, Yin, D, Wu, Z, Mao, Y. | 登録日 | 2021-11-25 | 公開日 | 2022-05-04 | 最終更新日 | 2022-06-01 | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | 主引用文献 | USP14-regulated allostery of the human proteasome by time-resolved cryo-EM. Nature, 605, 2022
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7W39
| Structure of USP14-bound human 26S proteasome in state EA2.1_UBL | 分子名称: | 26S protease regulatory subunit 4, 26S protease regulatory subunit 6A, 26S protease regulatory subunit 6B, ... | 著者 | Zhang, S, Zou, S, Yin, D, Wu, Z, Mao, Y. | 登録日 | 2021-11-25 | 公開日 | 2022-05-04 | 最終更新日 | 2022-06-01 | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | 主引用文献 | USP14-regulated allostery of the human proteasome by time-resolved cryo-EM. Nature, 605, 2022
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