7W3K

Structure of USP14-bound human 26S proteasome in substrate-inhibited state SD4_USP14

This is a non-PDB format compatible entry.

Summary for 7W3K

• Entry DOI: 10.2210/pdb7w3k/pdb
• EMDB information: 32283
• Descriptor: 26S protease regulatory subunit 7, Isoform Long of Proteasome subunit alpha type-1, Proteasome subunit alpha type-3, ... (37 entities in total)
• Functional Keywords: proteasome, aaa-atpase, deubiquitinase, usp14, hydrolase
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 48
• Total formula weight: 1731853.56

Authors

Zhang, S.,Zou, S.,Yin, D.,Wu, Z.,Mao, Y. (deposition date: 2021-11-25, release date: 2022-05-04, Last modification date: 2022-06-01)

• Primary citation: Zhang, S.,Zou, S.,Yin, D.,Zhao, L.,Finley, D.,Wu, Z.,Mao, Y.; USP14-regulated allostery of the human proteasome by time-resolved cryo-EM.; Nature, 605:567-574, 2022; PubMed: 35477760; DOI: 10.1038/s41586-022-04671-8

Experimental method

ELECTRON MICROSCOPY (3.6 Å)