Crystal structure of M26V human DJ-1

Summary for 4S0Z

Related1P5F 2RK4 3B36
DescriptorProtein DJ-1, 1,2-ETHANEDIOL, ACETATE ION, ... (4 entities in total)
Functional Keywordsdj-1/thij/pfpi superfamily, oxidative stress response, chaperone
Biological sourceHomo sapiens (human)
Cellular locationCell membrane ; Lipid-anchor  Q99497
Total number of polymer chains1
Total molecular weight20474.58
Milkovic, N.M.,Wilson, M.A. (deposition date: 2015-01-07, release date: 2015-08-05, Last modification date: 2015-10-14)
Primary citation
Milkovic, N.M.,Catazaro, J.,Lin, J.,Halouska, S.,Kizziah, J.L.,Basiaga, S.,Cerny, R.L.,Powers, R.,Wilson, M.A.
Transient sampling of aggregation-prone conformations causes pathogenic instability of a parkinsonian mutant of DJ-1 at physiological temperature.
Protein Sci., 24:1671-1685, 2015
PubMed: 26234586 (PDB entries with the same primary citation)
DOI: 10.1002/pro.2762
MImport into Mendeley
Experimental method

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.13370.5%02.6%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
Download full validation reportDownload
PDB entries from 2020-08-05