PDB: 46200 件ウェブページステータス検索Chemie searchBIRD

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7X4U	Crystal structure of ERK2 with an allosteric inhibitor 2 分子名称: (2R,3R,4S,5R)-2-(4-AMINO-5-IODO-7H-PYRROLO[2,3-D]PYRIMIDIN-7-YL)-5-(HYDROXYMETHYL)TETRAHYDROFURAN-3,4-DIOL, 2-[BIS-(2-HYDROXY-ETHYL)-AMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, GLYCEROL, ... 著者 Yoshida, M, Kinoshita, T. 登録日 2022-03-03 公開日 2023-03-08 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (1.98 Å) 主引用文献 Structural basis for producing allosteric ERK2 inhibitors To Be Published
4E3C	X-ray crystal structure of human IKK2 in an active conformation 分子名称: Inhibitor of nuclear factor kappa-B kinase subunit beta 著者 Polley, S, Huang, D.B, Hauenstein, A.V, Ghosh, G, Huxford, T. 登録日 2012-03-09 公開日 2013-06-19 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (3.98 Å) 主引用文献 X-ray crystal structure of human IKK2 in an active conformation Plos.Biol., 2013
7XC1	Crystal structure of ERK2 with an allosteric inhibitor 3 分子名称: (2R,3R,4S,5R)-2-(4-AMINO-5-IODO-7H-PYRROLO[2,3-D]PYRIMIDIN-7-YL)-5-(HYDROXYMETHYL)TETRAHYDROFURAN-3,4-DIOL, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, GLYCEROL, ... 著者 Yoshida, M, Kinoshita, T. 登録日 2022-03-22 公開日 2023-03-22 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (2.09 Å) 主引用文献 Structural basis for ERK2 allosteric inhibitors. To Be Published
4ES0	X-ray structure of WDR5-SETd1b Win motif peptide binary complex 分子名称: Histone-lysine N-methyltransferase SETD1B, WD repeat-containing protein 5 著者 Dharmarajan, V, Lee, J.-H, Patel, A, Skalnik, D.G, Cosgrove, M.S. 登録日 2012-04-21 公開日 2012-05-30 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (1.817 Å) 主引用文献 Structural basis for WDR5 interaction (Win) motif recognition in human SET1 family histone methyltransferases. J.Biol.Chem., 287, 2012
4MD8	Crystal Structure of full-length symmetric CK2 holoenzyme with mutated alpha subunit (F121E) 分子名称: Casein kinase II subunit alpha, Casein kinase II subunit beta, ZINC ION 著者 Lolli, G, Ranchio, A, Battistutta, R. 登録日 2013-08-22 公開日 2013-11-20 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (3.3 Å) 主引用文献 Active Form of the Protein Kinase CK2 alpha 2 beta 2 Holoenzyme Is a Strong Complex with Symmetric Architecture. Acs Chem.Biol., 9, 2014
3LOC	Crystal structure of putative transcriptional regulator ycdc 分子名称: HTH-type transcriptional regulator rutR, URACIL 著者 Patskovsky, Y.V, Knapik, A.A, Mennella, V, Burley, S.K, Minor, W, Almo, S.C, New York SGX Research Center for Structural Genomics (NYSGXRC) 登録日 2010-02-03 公開日 2010-03-16 最終更新日 2022-04-13 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Crystal Structure of Hypothetical Transcriptional Regulator Ycdc from Escherichia Coli To be Published
7PU5	Structure of SFPQ-NONO complex 分子名称: MAGNESIUM ION, Non-POU domain-containing octamer-binding protein, Splicing factor, ... 著者 Fribourg, S. 登録日 2021-09-28 公開日 2022-03-16 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (2.999 Å) 主引用文献 Crystal structure of SFPQ-NONO heterodimer. Biochimie, 198, 2022
3SOH	Architecture of the Flagellar Rotor 分子名称: Flagellar motor switch protein FliG, Flagellar motor switch protein FliM 著者 Koushik, P, Gonzalez-Bonet, G, Bilwes, A.M, Crane, B.R, Blair, D. 登録日 2011-06-30 公開日 2011-07-27 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (3.5 Å) 主引用文献 Architecture of the flagellar rotor. Embo J., 30, 2011
3SQ6	Crystal Structures of the Ligand Binding Domain of a Pentameric Alpha7 Nicotinic Receptor Chimera with its Agonist Epibatidine 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, EPIBATIDINE, ... 著者 Li, S.-X, Huang, S, Bren, N, Noridomi, K, Dellisanti, C, Sine, S, Chen, L. 登録日 2011-07-05 公開日 2011-09-28 最終更新日 2024-10-09 実験手法 X-RAY DIFFRACTION (2.8 Å) 主引用文献 Ligand-binding domain of an alpha 7-nicotinic receptor chimera and its complex with agonist. Nat.Neurosci., 14, 2011
3SR4	Crystal Structure of Human DOT1L in Complex with a Selective Inhibitor 分子名称: (2S)-2-azanyl-4-[[(2S,3S,4R,5R)-5-[6-(methylamino)purin-9-yl]-3,4-bis(oxidanyl)oxolan-2-yl]methylsulfanyl]butanoic acid, ACETATE ION, GLYCEROL, ... 著者 Diao, J, Chen, P, Yao, Y, Prasad, B.V.V, Song, Y. 登録日 2011-07-06 公開日 2011-10-05 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Selective Inhibitors of Histone Methyltransferase DOT1L: Design, Synthesis, and Crystallographic Studies. J.Am.Chem.Soc., 133, 2011
3T9I	Pim1 complexed with a novel 3,6-disubstituted indole at 2.6 Ang Resolution 分子名称: 2-methoxy-4-(3-phenyl-2H-pyrazolo[3,4-b]pyridin-6-yl)phenol, Proto-oncogene serine/threonine-protein kinase pim-1 著者 Bellamacina, C, Shu, W, Le, V, Nishiguchi, G, Bussiere, D. 登録日 2011-08-02 公開日 2011-10-12 最終更新日 2011-11-02 実験手法 X-RAY DIFFRACTION (2.6 Å) 主引用文献 Discovery of novel 3,5-disubstituted indole derivatives as potent inhibitors of Pim-1, Pim-2, and Pim-3 protein kinases. Bioorg.Med.Chem.Lett., 21, 2011
3T1Y	Structure of the Thermus thermophilus 30S ribosomal subunit complexed with a human anti-codon stem loop (HASL) of transfer RNA Lysine 3 (TRNALYS3) bound to an mRNA with an AAG-codon in the A-site and paromomycin 分子名称: 16S rRNA, 30S ribosomal protein S10, 30S ribosomal protein S11, ... 著者 Murphy, F.V, Vendeix, F.A.P, Cantara, W, Leszczynska, G, Gustilo, E.M, Sproat, B, Malkiewicz, A.A.P, Agris, P.F. 登録日 2011-07-22 公開日 2012-01-25 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (2.8 Å) 主引用文献 Human tRNA(Lys3)(UUU) Is Pre-Structured by Natural Modifications for Cognate and Wobble Codon Binding through Keto-Enol Tautomerism. J.Mol.Biol., 416, 2012
3T7R	Crystal structure of apo BVU_3255, a methyltransferase from Bacteroides vulgatus ATCC 8482 分子名称: 3-[(2Z)-3-methylpent-2-en-1-yl]benzene-1,2-diol, Putative methyltransferase 著者 Kumar, V, Sivaraman, J. 登録日 2011-07-31 公開日 2011-10-12 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (2.9 Å) 主引用文献 Structural characterization of BVU_3255, a methyltransferase from human intestine antibiotic resistant pathogen Bacteroides vulgatus J.Struct.Biol., 2011
3SQ9	Crystal Structures of the Ligand Binding Domain of a Pentameric Alpha7 Nicotinic Receptor Chimera 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Neuronal acetylcholine receptor subunit alpha-7, ... 著者 Li, S.-X, Huang, S, Bren, N, Noridomi, K, Dellisanti, C, Sine, S, Chen, L. 登録日 2011-07-05 公開日 2011-09-28 最終更新日 2024-10-09 実験手法 X-RAY DIFFRACTION (3.1 Å) 主引用文献 Ligand-binding domain of an alpha 7-nicotinic receptor chimera and its complex with agonist. Nat.Neurosci., 14, 2011
3TDA	Competitive replacement of thioridazine by prinomastat in crystals of cytochrome P450 2D6 分子名称: Cytochrome P450 2D6, PROTOPORPHYRIN IX CONTAINING FE, Prinomastat, ... 著者 Wang, A, Stout, C.D, Johnson, E.F. 登録日 2011-08-10 公開日 2012-08-15 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (2.67 Å) 主引用文献 Contributions of Ionic Interactions and Protein Dynamics to Cytochrome P450 2D6 (CYP2D6) Substrate and Inhibitor Binding. J.Biol.Chem., 290, 2015
3SY2	Crystal structure of the Salmonella E3 ubiquitin ligase SopA in complex with the human E2 UbcH7 分子名称: E3 ubiquitin-protein ligase SopA, SULFATE ION, Ubiquitin-conjugating enzyme E2 L3 著者 Diao, J, Lin, D.Y, Chen, J. 登録日 2011-07-15 公開日 2012-01-25 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (3.27 Å) 主引用文献 Crystal structures of two bacterial HECT-like E3 ligases in complex with a human E2 reveal atomic details of pathogen-host interactions. Proc.Natl.Acad.Sci.USA, 109, 2012
6O9K	70S initiation complex 分子名称: 16S rRNA, 23S rRNA, 30S ribosomal protein S10, ... 著者 Frank, J, Gonzalez Jr, R.L, kaledhonkar, S, Fu, Z, Caban, K, Li, W, Chen, B, Sun, M. 登録日 2019-03-14 公開日 2019-05-29 最終更新日 2019-12-18 実験手法 ELECTRON MICROSCOPY (4 Å) 主引用文献 Late steps in bacterial translation initiation visualized using time-resolved cryo-EM. Nature, 570, 2019
6O9J	70S Elongation Competent Ribosome 分子名称: 16S rRNA, 23S rRNA, 30S ribosomal protein S10, ... 著者 Frank, J, Gonzalez Jr, R.L, Kaledhonkar, S, Fu, Z, Caban, K, Li, W, Chen, B, Sun, M. 登録日 2019-03-14 公開日 2019-05-29 最終更新日 2024-03-20 実験手法 ELECTRON MICROSCOPY (3.9 Å) 主引用文献 Late steps in bacterial translation initiation visualized using time-resolved cryo-EM. Nature, 570, 2019
6ORL	RF1 pre-accommodated 70S complex at 24 ms 分子名称: 16S ribosomal RNA, 23S ribosomal RNA, 30S ribosomal protein S10, ... 著者 Fu, Z, Indrisiunaite, G, Kaledhonkar, S, Shah, B, Sun, M, Chen, B, Grassucci, R.A, Ehrenberg, M, Frank, J. 登録日 2019-04-30 公開日 2019-06-19 最終更新日 2019-12-18 実験手法 ELECTRON MICROSCOPY (3.5 Å) 主引用文献 The structural basis for release-factor activation during translation termination revealed by time-resolved cryogenic electron microscopy. Nat Commun, 10, 2019
8JLX	CCHFV envelope protein Gc in complex with Gc13 分子名称: Glycoprotein C,CCHFV Gc fusion loops, Mouse antibody Gc13 heavy chain, Mouse antibody Gc13 light chain 著者 Chong, T, Cao, S. 登録日 2023-06-03 公開日 2024-01-24 最終更新日 2024-02-28 実験手法 ELECTRON MICROSCOPY (3 Å) 主引用文献 Neutralizing monoclonal antibodies against the Gc fusion loop region of Crimean-Congo hemorrhagic fever virus. Plos Pathog., 20, 2024
8IXJ	Middle segment of the bacteriophage M13 mini variant 分子名称: Capsid protein G8P 著者 Xiang, Y, Jia, Q. 登録日 2023-04-01 公開日 2023-08-16 最終更新日 2023-09-20 実験手法 ELECTRON MICROSCOPY (3.1 Å) 主引用文献 Cryo-EM structure of a bacteriophage M13 mini variant. Nat Commun, 14, 2023
8JJ6	Structure of the NELF-BCE complex 分子名称: NELF-E, Negative elongation factor B, Negative elongation factor complex member C/D 著者 Wang, Z, Cao, Y, Qin, Y. 登録日 2023-05-29 公開日 2023-08-30 最終更新日 2024-09-11 実験手法 X-RAY DIFFRACTION (2.72 Å) 主引用文献 Structural basis of the human negative elongation factor NELF-B/C/E ternary complex. Biochem.Biophys.Res.Commun., 677, 2023
8IXK	bottom segment of the bacteriophage M13 mini variant 分子名称: Attachment protein G3P, Capsid protein G8P, Head virion protein G6P 著者 Xiang, Y, Jia, Q. 登録日 2023-04-01 公開日 2023-09-13 最終更新日 2023-09-20 実験手法 ELECTRON MICROSCOPY (3.3 Å) 主引用文献 Cryo-EM structure of a bacteriophage M13 mini variant. Nat Commun, 14, 2023
8IXL	top segment of the bacteriophage M13 mini variant 分子名称: Capsid protein G8P, Tail virion protein G7P, Tail virion protein G9P 著者 Xiang, Y, Jia, Q. 登録日 2023-04-01 公開日 2023-09-13 最終更新日 2023-09-20 実験手法 ELECTRON MICROSCOPY (3.5 Å) 主引用文献 Cryo-EM structure of a bacteriophage M13 mini variant. Nat Commun, 14, 2023
8JLW	CCHFV envelope protein Gc in complex with Gc8 分子名称: Glycoprotein C,CCHFV envelope protein Gc fusion loops, Mouse antibody Gc8 heavy chain, Mouse antibody Gc8 light chain 著者 Chong, T, Cao, S. 登録日 2023-06-03 公開日 2024-01-24 最終更新日 2024-02-28 実験手法 ELECTRON MICROSCOPY (3 Å) 主引用文献 Neutralizing monoclonal antibodies against the Gc fusion loop region of Crimean-Congo hemorrhagic fever virus. Plos Pathog., 20, 2024

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