7X4U

Crystal structure of ERK2 with an allosteric inhibitor 2

Summary for 7X4U

• Entry DOI: 10.2210/pdb7x4u/pdb
• Descriptor: Mitogen-activated protein kinase 1, (2R,3R,4S,5R)-2-(4-AMINO-5-IODO-7H-PYRROLO[2,3-D]PYRIMIDIN-7-YL)-5-(HYDROXYMETHYL)TETRAHYDROFURAN-3,4-DIOL, N-(1,3-benzodioxol-5-ylmethyl)-2-[3-(3,4-dimethylphenyl)-7-oxidanylidene-[1,2,3]triazolo[4,5-d]pyrimidin-6-yl]ethanamide, ... (7 entities in total)
• Functional Keywords: protein kinase allosteric inhibitor, transferase
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 1
• Total formula weight: 43637.61

Authors

Yoshida, M.,Kinoshita, T. (deposition date: 2022-03-03, release date: 2023-03-08, Last modification date: 2023-11-29)

• Primary citation: Kinoshita, T.,Yoshida, M.,Sugiyama, H.; Structural basis for producing allosteric ERK2 inhibitors; To Be Published,

Experimental method

X-RAY DIFFRACTION (1.98 Å)