3SR4

Crystal Structure of Human DOT1L in Complex with a Selective Inhibitor

Summary for 3SR4

Entry DOI	10.2210/pdb3sr4/pdb
Related	1NW3 3QOW 3QOX
Descriptor	Histone-lysine N-methyltransferase, H3 lysine-79 specific, (2S)-2-azanyl-4-[[(2S,3S,4R,5R)-5-[6-(methylamino)purin-9-yl]-3,4-bis(oxidanyl)oxolan-2-yl]methylsulfanyl]butanoic acid, GLYCEROL, ... (6 entities in total)
Functional Keywords	hdot1, histone lysine methyltransferase, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological source	Homo sapiens (human)
Cellular location	Nucleus (Probable): Q8TEK3
Total number of polymer chains	1
Total formula weight	41396.86
Authors	Diao, J.,Chen, P.,Yao, Y.,Prasad, B.V.V.,Song, Y. (deposition date: 2011-07-06, release date: 2011-10-05, Last modification date: 2023-09-13)
Primary citation	Yao, Y.,Chen, P.,Diao, J.,Cheng, G.,Deng, L.,Anglin, J.L.,Prasad, B.V.,Song, Y. Selective Inhibitors of Histone Methyltransferase DOT1L: Design, Synthesis, and Crystallographic Studies. J.Am.Chem.Soc., 133:16746-16749, 2011 Cited by PubMed: 21936531 DOI: 10.1021/ja206312b PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.5 Å)

Structure validation