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3SR4

Crystal Structure of Human DOT1L in Complex with a Selective Inhibitor

Functional Information from GO Data
ChainGOidnamespacecontents
A0031151molecular_functionhistone H3K79 methyltransferase activity
A0051726biological_processregulation of cell cycle
Functional Information from PDB Data
site_idAC1
Number of Residues20
DetailsBINDING SITE FOR RESIDUE TT8 A 417
ChainResidue
APRO133
AVAL169
AGLU186
ALYS187
AGLY221
AASP222
APHE223
APHE239
APHE245
AHOH365
AHOH391
ATYR136
AHOH419
AGLY137
AGLU138
ATHR139
AASP161
AGLY163
ASER164
AGLN168

site_idAC2
Number of Residues4
DetailsBINDING SITE FOR RESIDUE GOL A 500
ChainResidue
AHIS31
AASP32
AASN116
AHOH434

site_idAC3
Number of Residues4
DetailsBINDING SITE FOR RESIDUE ACT A 600
ChainResidue
AVAL160
ATYR183
AARG231
ATHR235

site_idAC4
Number of Residues4
DetailsBINDING SITE FOR RESIDUE SO4 A 700
ChainResidue
AARG203
ALYS207
AHIS213
AHOH381

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues314
DetailsDomain: {"description":"DOT1","evidences":[{"source":"PROSITE-ProRule","id":"PRU00902","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

site_idSWS_FT_FI2
Number of Residues14
DetailsBinding site: {}
ChainResidueDetails

site_idSWS_FT_FI3
Number of Residues1
DetailsModified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

240971

PDB entries from 2025-08-27

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