3TDA
Competitive replacement of thioridazine by prinomastat in crystals of cytochrome P450 2D6
Summary for 3TDA
| Entry DOI | 10.2210/pdb3tda/pdb |
| Related | 3QM4 |
| Descriptor | Cytochrome P450 2D6, PROTOPORPHYRIN IX CONTAINING FE, Prinomastat, ... (5 entities in total) |
| Functional Keywords | monooxygenase, heme, prinomastat, oxidoreductase-oxidoreductase inhibitor complex, oxidoreductase/oxidoreductase inhibitor |
| Biological source | Homo sapiens (human) |
| Cellular location | Endoplasmic reticulum membrane; Peripheral membrane protein: P10635 |
| Total number of polymer chains | 4 |
| Total formula weight | 219409.28 |
| Authors | Wang, A.,Stout, C.D.,Johnson, E.F. (deposition date: 2011-08-10, release date: 2012-08-15, Last modification date: 2023-09-13) |
| Primary citation | Wang, A.,Stout, C.D.,Zhang, Q.,Johnson, E.F. Contributions of Ionic Interactions and Protein Dynamics to Cytochrome P450 2D6 (CYP2D6) Substrate and Inhibitor Binding. J.Biol.Chem., 290:5092-5104, 2015 Cited by PubMed: 25555909DOI: 10.1074/jbc.M114.627661 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2.67 Å) |
Structure validation
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