4ES0

X-ray structure of WDR5-SETd1b Win motif peptide binary complex

Summary for 4ES0

• Entry DOI: 10.2210/pdb4es0/pdb
• Related: 4ERQ 4ERY 4ERZ 4ESG
• Descriptor: WD repeat-containing protein 5, Histone-lysine N-methyltransferase SETD1B (3 entities in total)
• Functional Keywords: wd40, win motif, beta propeller, 3-10 helix, lysine methyltransferase, setd1b, rbbp5, mll1, ash2l, core complex, histone, transcription-transferase complex, transcription/transferase
• Biological source: Homo sapiens (human); More
• Cellular location: Nucleus : P61964; Nucleus speckle : Q9UPS6
• Total number of polymer chains: 2
• Total formula weight: 35862.58

Authors

Dharmarajan, V.,Lee, J.-H.,Patel, A.,Skalnik, D.G.,Cosgrove, M.S. (deposition date: 2012-04-21, release date: 2012-05-30, Last modification date: 2024-02-28)

• Primary citation: Dharmarajan, V.,Lee, J.H.,Patel, A.,Skalnik, D.G.,Cosgrove, M.S.; Structural basis for WDR5 interaction (Win) motif recognition in human SET1 family histone methyltransferases.; J.Biol.Chem., 287:27275-27289, 2012; PubMed: 22665483; DOI: 10.1074/jbc.M112.364125

Experimental method

X-RAY DIFFRACTION (1.817 Å)