X-ray structure of WDR5-SETd1b Win motif peptide binary complex

Summary for 4ES0

Related4ERQ 4ERY 4ERZ 4ESG
DescriptorWD repeat-containing protein 5, Histone-lysine N-methyltransferase SETD1B (3 entities in total)
Functional Keywordswd40, win motif, beta propeller, 3-10 helix, lysine methyltransferase, setd1b, rbbp5, mll1, ash2l, core complex, histone, transcription-transferase complex, transcription/transferase
Biological sourceHomo sapiens (human)
Cellular locationNucleus  P61964
Nucleus speckle  Q9UPS6
Total number of polymer chains2
Total molecular weight35862.59
Dharmarajan, V.,Lee, J.-H.,Patel, A.,Skalnik, D.G.,Cosgrove, M.S. (deposition date: 2012-04-21, release date: 2012-05-30, Last modification date: 2017-11-15)
Primary citation
Dharmarajan, V.,Lee, J.H.,Patel, A.,Skalnik, D.G.,Cosgrove, M.S.
Structural basis for WDR5 interaction (Win) motif recognition in human SET1 family histone methyltransferases.
J.Biol.Chem., 287:27275-27289, 2012
PubMed: 22665483 (PDB entries with the same primary citation)
DOI: 10.1074/jbc.M112.364125
MImport into Mendeley
Experimental method

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers 0.22630 0.4% 4.8%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
Download full validation reportDownload
PDB entries from 2020-12-02