7XC1

Crystal structure of ERK2 with an allosteric inhibitor 3

Summary for 7XC1

• Entry DOI: 10.2210/pdb7xc1/pdb
• Descriptor: Mitogen-activated protein kinase 1, (2R,3R,4S,5R)-2-(4-AMINO-5-IODO-7H-PYRROLO[2,3-D]PYRIMIDIN-7-YL)-5-(HYDROXYMETHYL)TETRAHYDROFURAN-3,4-DIOL, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, ... (7 entities in total)
• Functional Keywords: protein kinase mapk inhibitor, transferase, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 2
• Total formula weight: 86791.66

Authors

Yoshida, M.,Kinoshita, T. (deposition date: 2022-03-22, release date: 2023-03-22, Last modification date: 2023-11-29)

• Primary citation: Yoshida, M.,Kinoshita, T.; Structural basis for ERK2 allosteric inhibitors.; To Be Published,

Experimental method

X-RAY DIFFRACTION (2.09 Å)