9BKJ
| Cholecystokinin 1 receptor (CCK1R) Y140A mutant, Gq chimera (mGsqi) complex | 分子名称: | AMINO GROUP, Cholecystokinin receptor type A, Cholecystokinin-8, ... | 著者 | Cary, B.P, Harikumar, K.G, Zhao, P, Desai, A.J, Mobbs, J.M, Toufaily, C, Furness, S.G.B, Christopoulos, A, Belousoff, M.J, Wootten, D, Sexton, P.M, Miller, L.J. | 登録日 | 2024-04-29 | 公開日 | 2024-05-22 | 最終更新日 | 2024-08-14 | 実験手法 | ELECTRON MICROSCOPY (2.59 Å) | 主引用文献 | Cholesterol-dependent dynamic changes in the conformation of the type 1 cholecystokinin receptor affect ligand binding and G protein coupling. Plos Biol., 22, 2024
|
|
8YOP
| Cryo-EM structure of the human 80S ribosome with 4 um Tigecycline | 分子名称: | 18S rRNA, 28S rRNA, 40S ribosomal protein S10, ... | 著者 | Li, X, Wang, M, Denk, T, Cheng, J. | 登録日 | 2024-03-13 | 公開日 | 2024-07-10 | 実験手法 | ELECTRON MICROSCOPY (2.2 Å) | 主引用文献 | Structural basis for differential inhibition of eukaryotic ribosomes by tigecycline. Nat Commun, 15, 2024
|
|
8XSZ
| Cryo-EM structure of the human 80S ribosome with Tigecycline, E-tRNA and P-tRNA | 分子名称: | 18S rRNA, 28S rRNA, 40S ribosomal protein S10, ... | 著者 | Li, X, Wang, M, Cheng, J. | 登録日 | 2024-01-10 | 公開日 | 2024-07-10 | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | 主引用文献 | Structural basis for differential inhibition of eukaryotic ribosomes by tigecycline. Nat Commun, 15, 2024
|
|
8XSY
| Cryo-EM structure of the human 80S ribosome with Tigecycline, e-tRNA and CCDC124 (40S head Swivelled) | 分子名称: | 18S rRNA, 28S rRNA, 40S ribosomal protein S10, ... | 著者 | Li, X, Wang, M, Cheng, J. | 登録日 | 2024-01-10 | 公開日 | 2024-07-10 | 実験手法 | ELECTRON MICROSCOPY (3 Å) | 主引用文献 | Structural basis for differential inhibition of eukaryotic ribosomes by tigecycline. Nat Commun, 15, 2024
|
|
8ZBE
| cryo-EM structure of the octreotide-bound SSTR5-Gi complex | 分子名称: | Beta-2 adrenergic receptor,Somatostatin receptor type 5,lgbit (fusion protein), Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(i) subunit alpha-1, ... | 著者 | Li, Y.G, Meng, X.Y, Yang, X.R, Ling, S.L, Shi, P, Tian, C.L, Yang, F. | 登録日 | 2024-04-26 | 公開日 | 2024-07-10 | 実験手法 | ELECTRON MICROSCOPY (3.24 Å) | 主引用文献 | Structural insights into somatostatin receptor 5 bound with cyclic peptides. Acta Pharmacol.Sin., 2024
|
|
8ZSS
| Cryo-EM structure of the RO5263397-bound hTAAR1-Gs complex | 分子名称: | (4~{S})-4-(3-fluoranyl-2-methyl-phenyl)-1,3-oxazolidin-2-amine, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | 著者 | Jiang, K.X, Zheng, Y, Xu, F. | 登録日 | 2024-06-05 | 公開日 | 2024-07-24 | 実験手法 | ELECTRON MICROSCOPY (3.07 Å) | 主引用文献 | The versatile binding landscape of the TAAR1 pocket for LSD and other antipsychotic drug molecules. Cell Rep, 43, 2024
|
|
8ZSJ
| Cryo-EM structure of the apo hTAAR1-Gs complex | 分子名称: | CHOLESTEROL, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | 著者 | Jiang, K.X, Zheng, Y, Xu, F. | 登録日 | 2024-06-05 | 公開日 | 2024-07-24 | 実験手法 | ELECTRON MICROSCOPY (2.8 Å) | 主引用文献 | The versatile binding landscape of the TAAR1 pocket for LSD and other antipsychotic drug molecules. Cell Rep, 43, 2024
|
|
9BKK
| Cholecystokinin 1 receptor (CCK1R) sterol 7M mutant, Gq chimera (mGsqi) complex | 分子名称: | Cholecystokinin receptor type A, Cholecystokinin-8, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | 著者 | Harikumar, K.G, Zhao, P, Cary, B.P, Xu, X, Desai, A.J, Mobbs, J.I, Toufaily, C, Furness, S.G.B, Christopoulos, A, Belousoff, M.J, Wootten, D, Sexton, P.M, Miller, L.J. | 登録日 | 2024-04-29 | 公開日 | 2024-05-22 | 最終更新日 | 2024-08-14 | 実験手法 | ELECTRON MICROSCOPY (2.51 Å) | 主引用文献 | Cholesterol-dependent dynamic changes in the conformation of the type 1 cholecystokinin receptor affect ligand binding and G protein coupling. Plos Biol., 22, 2024
|
|
8XIQ
| Structure of L796778-SSTR3 G protein complex | 分子名称: | G-alpha i, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | 著者 | Wang, Y, Xu, Y, Xu, H.E, Zhuang, Y. | 登録日 | 2023-12-19 | 公開日 | 2024-07-03 | 実験手法 | ELECTRON MICROSCOPY (2.71 Å) | 主引用文献 | Selective ligand recognition and activation of somatostatin receptors SSTR1 and SSTR3 To Be Published
|
|
8Y0W
| dormant ribosome with eIF5A, eEF2 and SERBP1 | 分子名称: | 18S rRNA, 28S rRNA, 40S ribosomal protein S10, ... | 著者 | Du, M, Zeng, F. | 登録日 | 2024-01-23 | 公開日 | 2024-02-07 | 最終更新日 | 2024-08-21 | 実験手法 | ELECTRON MICROSCOPY (3.4 Å) | 主引用文献 | Implication of Stm1 in the protection of eIF5A, eEF2 and tRNA through dormant ribosomes. Front Mol Biosci, 11, 2024
|
|
8Y0X
| Dormant ribosome with SERBP1 | 分子名称: | 18S rRNA, 28S rRNA, 40S ribosomal protein S10, ... | 著者 | Du, M, Zeng, F. | 登録日 | 2024-01-23 | 公開日 | 2024-02-07 | 最終更新日 | 2024-08-21 | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | 主引用文献 | Implication of Stm1 in the protection of eIF5A, eEF2 and tRNA through dormant ribosomes. Front Mol Biosci, 11, 2024
|
|
8XJK
| Cloprosetnol bound Prostaglandin F2-alpha receptor-Gq Protein Complex | 分子名称: | (~{Z})-7-[(1~{R},2~{R},3~{R},5~{S})-2-[(~{E},3~{R})-4-(3-chloranylphenoxy)-3-oxidanyl-but-1-enyl]-3,5-bis(oxidanyl)cyclopentyl]hept-5-enoic acid, Antibody fragment scFv16, Engineered miniGq, ... | 著者 | Zhang, X, Li, X, Liu, G, Gong, W. | 登録日 | 2023-12-21 | 公開日 | 2024-02-28 | 最終更新日 | 2024-03-20 | 実験手法 | ELECTRON MICROSCOPY (2.63 Å) | 主引用文献 | Structural basis for ligand recognition and activation of the prostanoid receptors. Cell Rep, 43, 2024
|
|
8XJO
| U46619 bound Thromboxane A2 receptor-Gq Protein Complex | 分子名称: | (5Z)-7-{(1R,4S,5S,6R)-6-[(1E,3S)-3-hydroxyoct-1-en-1-yl]-2-oxabicyclo[2.2.1]hept-5-yl}hept-5-enoic acid, Antibody fragment scFv16, Engineered miniGq, ... | 著者 | Zhang, X, Li, X, Liu, G, Gong, W. | 登録日 | 2023-12-21 | 公開日 | 2024-02-28 | 最終更新日 | 2024-03-20 | 実験手法 | ELECTRON MICROSCOPY (3.11 Å) | 主引用文献 | Structural basis for ligand recognition and activation of the prostanoid receptors. Cell Rep, 43, 2024
|
|
8XJN
| Cloprosetnol bound Thromboxane A2 receptor-Gq Protein Complex | 分子名称: | (~{Z})-7-[(1~{R},2~{R},3~{R},5~{S})-2-[(~{E},3~{R})-4-(3-chloranylphenoxy)-3-oxidanyl-but-1-enyl]-3,5-bis(oxidanyl)cyclopentyl]hept-5-enoic acid, Antibody fragment scFv16, Engineered miniGq, ... | 著者 | Zhang, X, Li, X, Liu, G, Gong, W. | 登録日 | 2023-12-21 | 公開日 | 2024-02-28 | 最終更新日 | 2024-03-20 | 実験手法 | ELECTRON MICROSCOPY (3.06 Å) | 主引用文献 | Structural basis for ligand recognition and activation of the prostanoid receptors. Cell Rep, 43, 2024
|
|
8XJL
| PGF2-alpha bound Prostaglandin F2-alpha receptor-Gq Protein Complex | 分子名称: | (Z)-7-[(1R,2R,3R,5S)-3,5-bis(oxidanyl)-2-[(E,3S)-3-oxidanyloct-1-enyl]cyclopentyl]hept-5-enoic acid, Antibody fragment scFv16, Engineered miniGq, ... | 著者 | Zhang, X, Li, X, Liu, G, Gong, W. | 登録日 | 2023-12-21 | 公開日 | 2024-02-28 | 最終更新日 | 2024-03-20 | 実験手法 | ELECTRON MICROSCOPY (2.77 Å) | 主引用文献 | Structural basis for ligand recognition and activation of the prostanoid receptors. Cell Rep, 43, 2024
|
|
8W8R
| Cryo-EM structure of the AA-14-bound GPR101-Gs complex | 分子名称: | 1-(4-methylpyridin-2-yl)-3-[3-(trifluoromethyl)phenyl]thiourea, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | 著者 | Sun, J.P, Yu, X, Gao, N, Yang, F, Wang, J.Y, Yang, Z, Guan, Y, Wang, G.P. | 登録日 | 2023-09-04 | 公開日 | 2024-01-03 | 最終更新日 | 2024-04-10 | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | 主引用文献 | Structure of GPR101-Gs enables identification of ligands with rejuvenating potential. Nat.Chem.Biol., 20, 2024
|
|
8WW2
| GPR3/Gs complex | 分子名称: | CHOLESTEROL HEMISUCCINATE, G-protein coupled receptor 3, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | 著者 | He, Y, Xiong, Y. | 登録日 | 2023-10-24 | 公開日 | 2024-02-14 | 最終更新日 | 2024-03-20 | 実験手法 | ELECTRON MICROSCOPY (2.79 Å) | 主引用文献 | Identification of oleic acid as an endogenous ligand of GPR3. Cell Res., 34, 2024
|
|
9C82
| Structure of human ULK1C:PI3KC3-C1 supercomplex | 分子名称: | Beclin 1-associated autophagy-related key regulator, Beclin-1, Phosphatidylinositol 3-kinase catalytic subunit type 3, ... | 著者 | Chen, M, Hurley, J.H. | 登録日 | 2024-06-11 | 公開日 | 2024-07-03 | 実験手法 | ELECTRON MICROSCOPY (6.84 Å) | 主引用文献 | Structure and activation of the human autophagy-initiating ULK1C:PI3KC3-C1 supercomplex bioRxiv, 2023
|
|
9ERX
| Structural basis of D9-THC analog activity at the Cannabinoid 1 receptor | 分子名称: | (6aR,10aR)-9-(hydroxymethyl)-6,6-dimethyl-3-(2-methyloctan-2-yl)-6a,7,10,10a-tetrahydrobenzo[c]chromen-1-ol, Antibody ScFv16 Fab fragment, Cannabinoid receptor 1, ... | 著者 | Thorsen, T.S, Kulkarni, Y, Boggild, A, Drace, T, Nissen, P, Gajhede, M, Boesen, T, Kastrup, J.S, Gloriam, D. | 登録日 | 2024-03-25 | 公開日 | 2024-06-26 | 実験手法 | ELECTRON MICROSCOPY (2.9 Å) | 主引用文献 | Structural basis of Delta 9 -THC analog activity at the Cannabinoid 1 receptor. Res Sq, 2024
|
|
8WRB
| Lysophosphatidylserine receptor GPR34-Gi complex | 分子名称: | Antibody fragment scFv16, CHOLESTEROL, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | 著者 | Gong, W, Liu, G, Li, X, Wang, Y, Zhang, X. | 登録日 | 2023-10-13 | 公開日 | 2023-11-08 | 最終更新日 | 2023-12-20 | 実験手法 | ELECTRON MICROSCOPY (2.91 Å) | 主引用文献 | Structural basis for ligand recognition and signaling of the lysophosphatidylserine receptors GPR34 and GPR174. Plos Biol., 21, 2023
|
|
8WPU
| Human calcium-sensing receptor(CaSR) bound to cinacalcet in complex with Gq protein | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ... | 著者 | Ling, S.L, Meng, X.Y, Tian, C.L. | 登録日 | 2023-10-10 | 公開日 | 2023-11-22 | 最終更新日 | 2024-02-21 | 実験手法 | ELECTRON MICROSCOPY (3.1 Å) | 主引用文献 | Structural insights into asymmetric activation of the calcium-sensing receptor-G q complex. Cell Res., 34, 2024
|
|
8W88
| Cryo-EM structure of the SEP363856-bound TAAR1-Gs complex | 分子名称: | 1-[(7~{S})-5,7-dihydro-4~{H}-thieno[2,3-c]pyran-7-yl]-~{N}-methyl-methanamine, CHOLESTEROL, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | 著者 | Liu, H, Zheng, Y, Wang, Y, Wang, Y, He, X, Xu, P, Huang, S, Yuan, Q, Zhang, X, Wang, S, Xu, H.E, Xu, F. | 登録日 | 2023-09-01 | 公開日 | 2023-11-22 | 最終更新日 | 2024-01-03 | 実験手法 | ELECTRON MICROSCOPY (2.6 Å) | 主引用文献 | Recognition of methamphetamine and other amines by trace amine receptor TAAR1. Nature, 624, 2023
|
|
8W8B
| Cryo-EM structure of SEP-363856 bounded serotonin 1A (5-HT1A) receptor-Gi protein complex | 分子名称: | 1-[(7~{S})-5,7-dihydro-4~{H}-thieno[2,3-c]pyran-7-yl]-~{N}-methyl-methanamine, Antibody fragment scFv16, CHOLESTEROL, ... | 著者 | Liu, H, Zheng, Y, Wang, Y, Wang, Y, He, X, Xu, P, Huang, S, Yuan, Q, Zhang, X, Wang, S, Xu, H.E, Xu, F. | 登録日 | 2023-09-01 | 公開日 | 2023-11-22 | 最終更新日 | 2024-01-03 | 実験手法 | ELECTRON MICROSCOPY (3 Å) | 主引用文献 | Recognition of methamphetamine and other amines by trace amine receptor TAAR1. Nature, 624, 2023
|
|
8W87
| Cryo-EM structure of the METH-TAAR1 complex | 分子名称: | (2S)-N-methyl-1-phenylpropan-2-amine, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | 著者 | Liu, H, Zheng, Y, Wang, Y, Wang, Y, He, X, Xu, P, Huang, S, Yuan, Q, Zhang, X, Wang, S, Xu, H.E, Xu, F. | 登録日 | 2023-09-01 | 公開日 | 2023-11-22 | 最終更新日 | 2024-01-03 | 実験手法 | ELECTRON MICROSCOPY (2.8 Å) | 主引用文献 | Recognition of methamphetamine and other amines by trace amine receptor TAAR1. Nature, 624, 2023
|
|
8W8A
| Cryo-EM structure of the RO5256390-TAAR1 complex | 分子名称: | (4S)-4-[(2S)-2-phenylbutyl]-1,3-oxazolidin-2-imine, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | 著者 | Liu, H, Zheng, Y, Wang, Y, Wang, Y, He, X, Xu, P, Huang, S, Yuan, Q, Zhang, X, Wang, S, Xu, H.E, Xu, F. | 登録日 | 2023-09-01 | 公開日 | 2023-11-22 | 最終更新日 | 2024-01-03 | 実験手法 | ELECTRON MICROSCOPY (2.8 Å) | 主引用文献 | Recognition of methamphetamine and other amines by trace amine receptor TAAR1. Nature, 624, 2023
|
|