8ZH8
| Human GPR103 -Gq complex bound to QRFP26 | 分子名称: | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2,Guanine nucleotide-binding protein G(i) subunit alpha-2,Guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | 著者 | Iwama, A, Akasaka, H, Sano, F.K, Oshima, H.S, Shihoya, W, Nureki, O. | 登録日 | 2024-05-10 | 公開日 | 2024-07-03 | 実験手法 | ELECTRON MICROSCOPY (3.19 Å) | 主引用文献 | Structure and dynamics of the pyroglutamylated RF-amide peptide QRFP receptor GPR103. Nat Commun, 15, 2024
|
|
8XWQ
| Cryo-EM structure of ET-1 bound ETBR-DNGI complex | 分子名称: | Endothelin receptor type B, Endothelin-1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | 著者 | Tani, K, Maki-Yonekura, S, Kanno, R, Negami, T, Hamaguchi, T, Hall, M, Mizoguchi, A, Humbel, B.M, Terada, T, Yonekura, K, Doi, T. | 登録日 | 2024-01-16 | 公開日 | 2024-10-02 | 実験手法 | ELECTRON MICROSCOPY (4.6 Å) | 主引用文献 | Structure of endothelin ETB receptor-Gi complex in a conformation stabilized by the unique NPxxL motif Commun Biol, 2024
|
|
8YUV
| Cryo-EM structure of the immepip-bound H3R-Gi complex | 分子名称: | 4-(1H-imidazol-5-ylmethyl)piperidine, CHOLESTEROL, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | 著者 | Shen, Q, Tang, X, Wen, X, Cheng, S, Xiao, P, Zang, S, Shen, D, Jiang, L, Zheng, Y, Zhang, H, Xu, H, Mao, C, Zhang, M, Hu, W, Sun, J, Chen, Z, Zhang, Y. | 登録日 | 2024-03-27 | 公開日 | 2024-06-05 | 最終更新日 | 2024-07-03 | 実験手法 | ELECTRON MICROSCOPY (3 Å) | 主引用文献 | Molecular Determinant Underlying Selective Coupling of Primary G-Protein by Class A GPCRs. Adv Sci, 11, 2024
|
|
8YOO
| Cryo-EM structure of the human 80S ribosome with 100 um Tigecycline | 分子名称: | 18S rRNA, 28S rRNA, 40S ribosomal protein S10, ... | 著者 | Li, X, Wang, M, Denk, T, Cheng, J. | 登録日 | 2024-03-13 | 公開日 | 2024-07-10 | 実験手法 | ELECTRON MICROSCOPY (2 Å) | 主引用文献 | Structural basis for differential inhibition of eukaryotic ribosomes by tigecycline. Nat Commun, 15, 2024
|
|
8X16
| Cryo-EM structure of adenosine receptor A3AR bound to CF101 | 分子名称: | Adenosine receptor A3, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | 著者 | Cai, H, Xu, Y, Xu, H.E. | 登録日 | 2023-11-06 | 公開日 | 2024-04-24 | 最終更新日 | 2024-05-08 | 実験手法 | ELECTRON MICROSCOPY (3.29 Å) | 主引用文献 | Cryo-EM structures of adenosine receptor A 3 AR bound to selective agonists. Nat Commun, 15, 2024
|
|
8ZSP
| Cryo-EM structure of the LSD-bound hTAAR1-Gs complex | 分子名称: | (8alpha)-N,N-diethyl-6-methyl-9,10-didehydroergoline-8-carboxamide, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | 著者 | Jiang, K.X, Zheng, Y, Xu, F. | 登録日 | 2024-06-05 | 公開日 | 2024-07-24 | 実験手法 | ELECTRON MICROSCOPY (3.14 Å) | 主引用文献 | The versatile binding landscape of the TAAR1 pocket for LSD and other antipsychotic drug molecules. Cell Rep, 43, 2024
|
|
8XVI
| Cryo-EM structure of ETAR bound with Endothelin1 | 分子名称: | Endoglucanase H,Endothelin-1 receptor, Endothelin-1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | 著者 | Hou, J.Y, Liu, S.H, Wu, L.J, Liu, Z.J, Hua, T. | 登録日 | 2024-01-15 | 公開日 | 2024-08-28 | 実験手法 | ELECTRON MICROSCOPY (3.32 Å) | 主引用文献 | Structural basis of antagonist selectivity in endothelin receptors. Cell Discov, 10, 2024
|
|
8XVH
| Cryo-EM structure of ETBR bound with Endothelin1 | 分子名称: | Endothelin-1, Exo-alpha-sialidase,Endothelin receptor type B, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | 著者 | Hou, J.Y, Liu, S.H, Wu, L.J, Liu, Z.J, Hua, T. | 登録日 | 2024-01-15 | 公開日 | 2024-08-28 | 実験手法 | ELECTRON MICROSCOPY (3.26 Å) | 主引用文献 | Structural basis of antagonist selectivity in endothelin receptors. Cell Discov, 10, 2024
|
|
9BQJ
| RO76 bound muOR-Gi1-scFv16 complex structure | 分子名称: | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(i) subunit alpha-1, ... | 著者 | Wang, H, Majumdar, S, Kobilka, B.K. | 登録日 | 2024-05-10 | 公開日 | 2024-09-11 | 最終更新日 | 2024-10-09 | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | 主引用文献 | Signaling Modulation Mediated by Ligand Water Interactions with the Sodium Site at mu OR. Acs Cent.Sci., 10, 2024
|
|
9IQT
| structure of niacin-HCA2-Gi | 分子名称: | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(i) subunit alpha-1, ... | 著者 | Liu, Y, Zhou, Z. | 登録日 | 2024-07-13 | 公開日 | 2024-10-02 | 最終更新日 | 2024-10-09 | 実験手法 | ELECTRON MICROSCOPY (2.9 Å) | 主引用文献 | Ligand recognition and activation mechanism of the alicarboxylic acid receptors. J.Mol.Biol., 2024
|
|
8X2K
| OEA bound GPR3-Gs complex structure | 分子名称: | (Z)-N-(2-hydroxyethyl)octadec-9-enamide, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | 著者 | Geng, C, Yang, D, Jun, X. | 登録日 | 2023-11-09 | 公開日 | 2024-04-03 | 最終更新日 | 2024-10-09 | 実験手法 | ELECTRON MICROSCOPY (3.03 Å) | 主引用文献 | Structural and functional characterization of the endogenous agonist for orphan receptor GPR3. Cell Res., 34, 2024
|
|
8ZPS
| Cryo-EM structure of prolactin-releasing peptide recognition with Gi | 分子名称: | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(s) subunit alpha-1, ... | 著者 | Zhao, L, Li, Y, Yuan, Q, Xu, H.E. | 登録日 | 2024-05-31 | 公開日 | 2024-09-25 | 実験手法 | ELECTRON MICROSCOPY (2.97 Å) | 主引用文献 | Molecular mechanism of prolactin-releasing peptide recognition and signaling via its G protein-coupled receptor. Cell Discov, 10, 2024
|
|
9BDP
| |
8ZCJ
| Cryo-EM structure of the pasireotide-bound SSTR5-Gi complex | 分子名称: | 004-DTR-LYS-TYR-PHA-HYP, Beta-2 adrenergic receptor,Somatostatin receptor type 5,lgbit (fusion protein), Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | 著者 | Li, Y.G, Meng, X.Y, Yang, X.R, Ling, S.L, Shi, P, Tian, C.L, Yang, F. | 登録日 | 2024-04-29 | 公開日 | 2024-07-10 | 実験手法 | ELECTRON MICROSCOPY (3.09 Å) | 主引用文献 | Structural insights into somatostatin receptor 5 bound with cyclic peptides. Acta Pharmacol.Sin., 2024
|
|
8XVE
| Cryo-EM structure of ETBR bound with BQ3020 | 分子名称: | BQ3020, Exo-alpha-sialidase,Endothelin receptor type B, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | 著者 | Hou, J.Y, Liu, S.H, Wu, L.J, Liu, Z.J, Hua, T. | 登録日 | 2024-01-15 | 公開日 | 2024-08-28 | 実験手法 | ELECTRON MICROSCOPY (3 Å) | 主引用文献 | Structural basis of antagonist selectivity in endothelin receptors. Cell Discov, 10, 2024
|
|
9F1D
| Mammalian quaternary complex of a translating 80S ribosome, NAC, MetAP1 and NatA/E-HYPK | 分子名称: | 18S rRNA, 28S rRNA, 40S ribosomal protein S11, ... | 著者 | Yudin, D, Scaiola, A, Ban, N. | 登録日 | 2024-04-18 | 公開日 | 2024-08-21 | 最終更新日 | 2024-10-02 | 実験手法 | ELECTRON MICROSCOPY (3.26 Å) | 主引用文献 | NAC guides a ribosomal multienzyme complex for nascent protein processing. Nature, 633, 2024
|
|
8YUT
| Cryo-EM structure of the amthamine-bound H2R-Gs complex | 分子名称: | 5-(2-azanylethyl)-4-methyl-1,3-thiazol-2-amine, CHOLESTEROL, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | 著者 | Shen, Q, Tang, X, Wen, X, Cheng, S, Xiao, P, Zang, S, Shen, D, Jiang, L, Zheng, Y, Zhang, H, Xu, H, Mao, C, Zhang, M, Hu, W, Sun, J, Chen, Z, Zhang, Y. | 登録日 | 2024-03-27 | 公開日 | 2024-06-05 | 最終更新日 | 2024-07-03 | 実験手法 | ELECTRON MICROSCOPY (2.7 Å) | 主引用文献 | Molecular Determinant Underlying Selective Coupling of Primary G-Protein by Class A GPCRs. Adv Sci, 11, 2024
|
|
8Y6O
| Cryo-EM Structure of the human minor pre-B complex (pre-precatalytic spliceosome) U11 and tri-snRNP part | 分子名称: | 116 kDa U5 small nuclear ribonucleoprotein component, Centrosomal AT-AC splicing factor, GUANOSINE-5'-TRIPHOSPHATE, ... | 著者 | Bai, R, Yuan, M, Zhang, P, Luo, T, Shi, Y, Wan, R. | 登録日 | 2024-02-02 | 公開日 | 2024-03-20 | 最終更新日 | 2024-03-27 | 実験手法 | ELECTRON MICROSCOPY (3.38 Å) | 主引用文献 | Structural basis of U12-type intron engagement by the fully assembled human minor spliceosome. Science, 383, 2024
|
|
8XBH
| Human GPR34 -Gi complex bound to M1 | 分子名称: | (2~{S})-2-azanyl-3-[[(2~{R})-1-ethoxy-3-[3-[2-[(3-phenoxyphenyl)methoxy]phenyl]propanoyloxy]propan-2-yl]oxy-oxidanyl-phosphoryl]oxy-propanoic acid, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | 著者 | Kawahara, R, Shihoya, W, Nureki, O. | 登録日 | 2023-12-06 | 公開日 | 2023-12-27 | 最終更新日 | 2024-05-15 | 実験手法 | ELECTRON MICROSCOPY (2.83 Å) | 主引用文献 | Structural basis for lysophosphatidylserine recognition by GPR34. Nat Commun, 15, 2024
|
|
8XZF
| Cryo-EM structure of the WN561-bound human APLNR-Gi complex | 分子名称: | Apelin receptor, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | 著者 | Wang, W, Ji, S, Zhang, Y. | 登録日 | 2024-01-21 | 公開日 | 2024-03-20 | 最終更新日 | 2024-03-27 | 実験手法 | ELECTRON MICROSCOPY (3 Å) | 主引用文献 | Structure-based design of non-hypertrophic apelin receptor modulator. Cell, 187, 2024
|
|
8XJK
| Cloprosetnol bound Prostaglandin F2-alpha receptor-Gq Protein Complex | 分子名称: | (~{Z})-7-[(1~{R},2~{R},3~{R},5~{S})-2-[(~{E},3~{R})-4-(3-chloranylphenoxy)-3-oxidanyl-but-1-enyl]-3,5-bis(oxidanyl)cyclopentyl]hept-5-enoic acid, Antibody fragment scFv16, Engineered miniGq, ... | 著者 | Zhang, X, Li, X, Liu, G, Gong, W. | 登録日 | 2023-12-21 | 公開日 | 2024-02-28 | 最終更新日 | 2024-10-16 | 実験手法 | ELECTRON MICROSCOPY (2.63 Å) | 主引用文献 | Structural basis for ligand recognition and activation of the prostanoid receptors. Cell Rep, 43, 2024
|
|
8YOP
| Cryo-EM structure of the human 80S ribosome with 4 um Tigecycline | 分子名称: | 18S rRNA, 28S rRNA, 40S ribosomal protein S10, ... | 著者 | Li, X, Wang, M, Denk, T, Cheng, J. | 登録日 | 2024-03-13 | 公開日 | 2024-07-10 | 実験手法 | ELECTRON MICROSCOPY (2.2 Å) | 主引用文献 | Structural basis for differential inhibition of eukaryotic ribosomes by tigecycline. Nat Commun, 15, 2024
|
|
8YW3
| Cryo-EM structure of the retatrutide-bound human GLP-1R-Gs complex | 分子名称: | Glucagon-like peptide 1 receptor, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | 著者 | Li, W.Z, Zhou, Q.T, Cong, Z.T, Yuan, Q.N, Li, W.X, Zhao, F.H, Xu, H.E, Zhao, L.H, Yang, D.H, Wang, M.W. | 登録日 | 2024-03-29 | 公開日 | 2024-09-18 | 最終更新日 | 2024-09-25 | 実験手法 | ELECTRON MICROSCOPY (2.68 Å) | 主引用文献 | Structural insights into the triple agonism at GLP-1R, GIPR and GCGR manifested by retatrutide. Cell Discov, 10, 2024
|
|
8ZJD
| Cryo-EM structure of kisspeptin receptor bound to KP-10 | 分子名称: | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(i) subunit alpha-1,Guanine nucleotide-binding protein G(q) subunit alpha, ... | 著者 | Shen, S, Liu, H, Xu, H.E. | 登録日 | 2024-05-14 | 公開日 | 2024-07-03 | 実験手法 | ELECTRON MICROSCOPY (3.06 Å) | 主引用文献 | Cryo-EM structure of kisspeptin receptor bound to KP-10 To Be Published
|
|
9BKK
| Cholecystokinin 1 receptor (CCK1R) sterol 7M mutant, Gq chimera (mGsqi) complex | 分子名称: | Cholecystokinin receptor type A, Cholecystokinin-8, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | 著者 | Harikumar, K.G, Zhao, P, Cary, B.P, Xu, X, Desai, A.J, Mobbs, J.I, Toufaily, C, Furness, S.G.B, Christopoulos, A, Belousoff, M.J, Wootten, D, Sexton, P.M, Miller, L.J. | 登録日 | 2024-04-29 | 公開日 | 2024-05-22 | 最終更新日 | 2024-10-16 | 実験手法 | ELECTRON MICROSCOPY (2.51 Å) | 主引用文献 | Cholesterol-dependent dynamic changes in the conformation of the type 1 cholecystokinin receptor affect ligand binding and G protein coupling. Plos Biol., 22, 2024
|
|