8ZCJ

Cryo-EM structure of the pasireotide-bound SSTR5-Gi complex

Summary for 8ZCJ

• Entry DOI: 10.2210/pdb8zcj/pdb
• EMDB information: 39931
• Descriptor: Guanine nucleotide-binding protein G(i) subunit alpha-1, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... (6 entities in total)
• Functional Keywords: pasireotide, sstr5, cryo-em, membrane protein/immune system, membrane protein-immune system complex
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 6
• Total formula weight: 184976.49

Authors

Li, Y.G.,Meng, X.Y.,Yang, X.R.,Ling, S.L.,Shi, P.,Tian, C.L.,Yang, F. (deposition date: 2024-04-29, release date: 2024-07-10)

• Primary citation: Li, Y.G.,Meng, X.Y.,Yang, X.,Ling, S.L.,Shi, P.,Tian, C.L.,Yang, F.; Structural insights into somatostatin receptor 5 bound with cyclic peptides.; Acta Pharmacol.Sin., 2024; PubMed: 38926478; DOI: 10.1038/s41401-024-01314-8

Experimental method

ELECTRON MICROSCOPY (3.09 Å)